Brain-derived neurotrophic factor in multiple sclerosis

Semkina, A A; Алифирова, В. М.; Титова, М.; Maltseva, A. N.; Abadzhyan, M B

doi:10.17116/jnevro20191192228

Cited by 4 publications

(3 citation statements)

References 68 publications

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“…Endogenous BDNF protects against kainic acid-induced transneuronal degeneration in the substantia nigra and promotes sprouting of cortical serotonergic axons [18][19][20]. Previous studies have also proved the protective role of BDNF in EAE [21]. We also confirmed that CBX increased the expression of BDNF.…”

Section: Discussionsupporting

confidence: 82%

The Effects of Carbenoxolone against Experimental Autoimmune Encephalomyelitis in a Mouse Model

Chen¹,

Hu²,

Li³

et al. 2020

Neuroimmunomodulation

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Introduction: Multiple sclerosis (MS) is a complex demyelinating disease involving central nervous system (CNS). It is still a challenge to secure an effective therapeutic strategy against this disease. Carbenoxolone (CBX) is a derivative of glycyrrhetinic acid, which is widely used in brain research for its gap-junction inhibition effects. Many researchers have observed CBX-mediated suppression of CNS inflammation in their studies. Objective: We want to further examine its anti-inflammation effects in CNS demyelinating disease like MS. Methods: Thus, our study applied an experimental autoimmune encephalomyelitis (EAE) mouse model and examined the effects of CBX on it. Results and Conclusions: We found that CBX significantly reversed the EAE severity and pathology in EAE. IL-17-secreting and IFN-γ-secreting CD4+ T lymphocytes were remarkably lower in the spleen of CBXtreated mice. Production of IL-23 and IL-17 from cortex in EAE animals was markedly reduced by CBX. Furthermore, CBX treatment increased the expression of brain-derived neurotrophic factor. This study provides evidence for the protective role of CBX against EAE.

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Section: Discussionsupporting

confidence: 82%

The Effects of Carbenoxolone against Experimental Autoimmune Encephalomyelitis in a Mouse Model

Chen¹,

Hu²,

Li³

et al. 2020

Neuroimmunomodulation

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Section: Proteomics Approach In Multiple Sclerosismentioning

confidence: 99%

“…Studies recommended that serum levels of GFAP related to MRI lesion count, clinical seriousness scores, and disease progression in MS might be considered an effectively quantifiable biomarker of CNS pathology associated with disease progression. 80,81 Neurotransmitters, chemical messengers, participate in CNS function by transmitting a neuron signal across the target cell's synapse. Impaired neurotransmitter function was observed in many neurological disorders.…”

Section: Plasma and Csfmentioning

confidence: 99%

Multiple Sclerosis Biomarker Discoveries by Proteomics and Metabolomics Approaches

2021

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Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous system (CNS) resulting in demyelination and axonal loss in the brain and spinal cord. The precise pathogenesis and etiology of this complex disease are still a mystery. Despite many studies that have been aimed to identify biomarkers, no protein marker has yet been approved for MS. There is urgently needed for biomarkers, which could clarify pathology, monitor disease progression, response to treatment, and prognosis in MS. Proteomics and metabolomics analysis are powerful tools to identify putative and novel candidate biomarkers. Different human compartments analysis using proteomics, metabolomics, and bioinformatics approaches has generated new information for further clarification of MS pathology, elucidating the mechanisms of the disease, finding new targets, and monitoring treatment response. Overall, omics approaches can develop different therapeutic and diagnostic aspects of complex disorders such as multiple sclerosis, from biomarker discovery to personalized medicine.

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A systematic review with meta-analysis on balance, fatigue, and motor function following aquatic therapy in patients with multiple sclerosis

Shariat

Najafabadi

Fard

et al. 2022

Multiple Sclerosis and Related Disorders

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Brain-derived neurotrophic factor in multiple sclerosis

Cited by 4 publications

References 68 publications

The Effects of Carbenoxolone against Experimental Autoimmune Encephalomyelitis in a Mouse Model

The Effects of Carbenoxolone against Experimental Autoimmune Encephalomyelitis in a Mouse Model

Multiple Sclerosis Biomarker Discoveries by Proteomics and Metabolomics Approaches

A systematic review with meta-analysis on balance, fatigue, and motor function following aquatic therapy in patients with multiple sclerosis

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