Brain-Derived Neurotrophic Factor–Enriched Collagen Tubule as a Substitute for Autologous Nerve Grafts

Terris, David J.; Toft, Kenneth M.; Moir, Melinda S.; Lum, Joanne; Wang, Michelle

doi:10.1001/archotol.127.3.294

Cited by 41 publications

(24 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are many different histologic methods to evaluate facial nerve regeneration: evaluation of the facial nerve nucleus (13,14); using light microscopic analysis of myelin fibers (9,17,23,24,28), and electron microscopic evaluation of unmyelinated fibers (28). It is also a possibility to study the muscular fibers undergoing reinnervation (29).…”

Section: Discussionmentioning

confidence: 99%

“…Functional recuperation can be measured by means of behavioral (16,22,24,28) and electrophysiologic tests (30). Some of the objective tests also have drawbacks; for example, electromyography only provides information regarding the muscular group anatomically near the electrode and does not provide direct information regarding the functional integrity of facial musculature away from the electrode.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Action of Topical Basic Fibroblast Growth Factor in Facial Nerve Regeneration

Toledo

Borin²,

Cruz³

et al. 2010

Otology &Amp; Neurotology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Action of Topical Basic Fibroblast Growth Factor in Facial Nerve Regeneration

Toledo

Borin²,

Cruz³

et al. 2010

Otology &Amp; Neurotology

View full text Add to dashboard Cite

show abstract

“…24 Previous studies demonstrated that the addition of factors that promote nerve growth across the conduit may facilitate regeneration across a longer gap. [42][43][44][45] We selected a 15-week experimental period to ensure complete nerve regeneration, with the regenerated and myelinated axon in the distal stump.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Polyglycolic Acid Versus Type 1 Collagen Bioabsorbable Nerve Conduits in a Rat Model: An Alternative to Autografting

Waitayawinyu

Parisi

Miller

et al. 2007

The Journal of Hand Surgery

104

View full text Add to dashboard Cite

“…Although initial reports focused on short gap repairs, 5,18,26 several substrates have been studied for their potential to heal large gap defects when supplemented with AGCs, including purified SCs. 1,6,7,9,11,12,16,17,27,28,34,37,38,[40][41][42]44 Berrocal et al demonstrated that adding autologous SCs suspended in serum to AGCs significantly enhanced the ability to bridge larger gap distances in sciatic nerve repair in rats. 3 Autologous SCs can be harvested from either a donor nerve or from the epicenter of the traumatized nerve ends in sharp injuries (propeller injury, gunshot wound, stab wound).…”

Section: Discussionmentioning

confidence: 99%

First human experience with autologous Schwann cells to supplement sciatic nerve repair: report of 2 cases with long-term follow-up

Gersey

Burks

Anderson

et al. 2017

FOC

View full text Add to dashboard Cite

OBJECTIVE Long-segment injuries to large peripheral nerves present a challenge to surgeons because insufficient donor tissue limits repair. Multiple supplemental approaches have been investigated, including the use of Schwann cells (SCs). The authors present the first 2 cases using autologous SCs to supplement a peripheral nerve graft repair in humans with long-term follow-up data. METHODS Two patients were enrolled in an FDA-approved trial to assess the safety of using expanded populations of autologous SCs to supplement the repair of long-segment injuries to the sciatic nerve. The mechanism of injury included a boat propeller and a gunshot wound. The SCs were obtained from both the sural nerve and damaged sciatic nerve stump. The SCs were expanded and purified in culture by using heregulin β1 and forskolin. Repair was performed with sural nerve grafts, SCs in suspension, and a Duragen graft to house the construct. Follow-up was 36 and 12 months for the patients in Cases 1 and 2, respectively. RESULTS The patient in Case 1 had a boat propeller injury with complete transection of both sciatic divisions at midthigh. The graft length was approximately 7.5 cm. In the postoperative period the patient regained motor function (Medical Research Council [MRC] Grade 5/5) in the tibial distribution, with partial function in peroneal distribution (MRC Grade 2/5 on dorsiflexion). Partial return of sensory function was also achieved, and neuropathic pain was completely resolved. The patient in Case 2 sustained a gunshot wound to the leg, with partial disruption of the tibial division of the sciatic nerve at the midthigh. The graft length was 5 cm. Postoperatively the patient regained complete motor function of the tibial nerve, with partial return of sensation. Long-term follow-up with both MRI and ultrasound demonstrated nerve graft continuity and the absence of tumor formation at the repair site. CONCLUSIONS Presented here are the first 2 cases in which autologous SCs were used to supplement human peripheral nerve repair in long-segment injury. Both patients had significant improvement in both motor and sensory function with correlative imaging. This study demonstrates preliminary safety and efficacy of SC transplantation for peripheral nerve repair.

show abstract

Brain-Derived Neurotrophic Factor–Enriched Collagen Tubule as a Substitute for Autologous Nerve Grafts

Abstract: Collagen tubules filled with BDNF-enriched collagen gel appear to be at least as good as autologous nerve grafts for bridging short facial nerve gaps. Larger experimental studies are warranted to determine if clinical trials are justified.

Cited by 41 publications

References 22 publications

The Action of Topical Basic Fibroblast Growth Factor in Facial Nerve Regeneration

The Action of Topical Basic Fibroblast Growth Factor in Facial Nerve Regeneration

A Comparison of Polyglycolic Acid Versus Type 1 Collagen Bioabsorbable Nerve Conduits in a Rat Model: An Alternative to Autografting

First human experience with autologous Schwann cells to supplement sciatic nerve repair: report of 2 cases with long-term follow-up

Contact Info

Product

Resources

About