“…Hagan pigmented cells from the locus ceruleus in the brains of Alzheimer's patients. His observations have been confirmed (Mann et at., 1980(Mann et at., , 1982, and depleted biochemical markers for norepinephrine, dopamine, and serotonin receptors (Adolfsson et Arai et at., 1984;Bowen et at., 1974;Crow et al, 1984;Mann et at., 1982;Tomlinson et at., 1981;Yates et at., 1983) have since been reported. Reductions in glutamate binding (Greenamyre et at., 1985), central nervous system (CNS) somatostatin levels (Davies et at., 1980;Serby et at., 1984), and an apparent vulnerability of somatostatin-containing cells (Roberts et at., 1985;Morrison et at., 1985) have also been reported.…”