“…Oral administration of toxic ryegrass to sheep, or intraperitoneal (IP) injection of crude extracts to 2-week-old rats, causes lesions in the central nervous system (CNS) which may be due to vasoconstriction (Peterson and Jago, 1977;Berry, Howell and Cook, 1980). However, damage caused by ingested toxic ryegrass also occurs in other body systems, particularly the ovine liver, in which histological and ultrastructural changes suggest a cytotoxic effect (Berry etal, 1982).…”