Brain Atrophy after Foetal Exposure to Very Low Doses of Ionizing Radiation

Reyners, H.; Reyners, E. Gianfelici de; Poortmans, F.; Crametz, A.; Coffigny, Hervé; Maisin, J

doi:10.1080/09553009214552541

Cited by 30 publications

(7 citation statements)

References 11 publications

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“…(Uma Devi and Baskar, 1996). Reyners et al (1992) reported a reduction in brain weight when rats were exposed to gamma doses below 1 Gy continuously from days 12–16 to 14–20 p.c. A dose between 0.4 and 0.8 Gy of both beta and gamma radiation caused significant reduction in brain weight in adult mice (Sun et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Late effect of prenatal irradiation on the hippocampal histology and brain weight in adult mice

Hossain

Chetana

Devi

2005

Intl J of Devlp Neuroscience

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We studied the changes in the brain weight and hippocampal histology in adult offspring exposed to 0.25-1.5 Gy of 60Co gamma radiations during day 14 or 17 of gestation. Irradiation with 0.5-1.5 Gy produced a significant decrease in brain weight of the offspring at 6 and 12 months of age. Exposure to 1 Gy at day 14 or 17 of gestation resulted in significant decrease in the number of neurons in the CA3 and CA4 regions of hippocampus of 200 microm length, while 1.5 Gy significantly affected CA1 region also. The fetal period (13-18 days of gestation) of mouse development is an active phase of brain development involving proliferation, migration and differentiation of cerebral cortex and associated structures. The present results show that exposure at this period of mouse development to moderate doses of gamma radiation can induce permanent deficits in the brain histology, which can adversely affect the learning and memory in adults.

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Section: Discussionmentioning

confidence: 99%

Late effect of prenatal irradiation on the hippocampal histology and brain weight in adult mice

Hossain

Chetana

Devi

2005

Intl J of Devlp Neuroscience

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“…hexandrum extract has been shown to render radioprotection to the developing nervous system (Goel et al, 2002c). Since cells of the embryonic nervous system are radiosensitive and actively differentiating and maturing during the fetal and early postnatal periods (Reyners et al, 1992), the effect of sublethal (2 Gy) γ-radiation was studied in rats in utero on day 17 of gestation to monitor radiation-induced retardation of neurophysiological development in new-borns. Treatment of rats with P. hexandrum extract (200 mg/kg b.w.…”

Section: Podophyllum Hexandrum Royale (Syn P Emodi Wall)mentioning

confidence: 99%

Radioprotection by plant products: present status and future prospects

Arora

Gupta

Chawla

et al. 2005

Phytotherapy Research

296

188

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The development of radioprotective agents has been the subject of intense research in view of their potential for use within a radiation environment, such as space exploration, radiotherapy and even nuclear war. However, no ideal, safe synthetic radioprotectors are available to date, so the search for alternative sources, including plants, has been on going for several decades. In Ayurveda, the traditional Indian system of medicine, several plants have been used to treat free radical-mediated ailments and, therefore, it is logical to expect that such plants may also render some protection against radiation damage. A systematic screening approach can provide leads to identifying potential new candidate drugs from plant sources, for mitigation of radiation injury. This article reviews some of the most promising plants, and their bioactive principles, that are widely used in traditional systems of medicine, and which have rendered significant radioprotection in both in vitro and in vivo model systems. Plants and their constituents with pharmacological activities that may be relevant to amelioration of radiation-mediated damage, including antiemetic, antiinflammatory, antioxidant, cell proliferative, wound healing and haemopoietic stimulatories are also discussed.

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“…Comparable dose-dependent relationships have also been suggested in other indicators of brain morphology in mice (Lent andSchmidt 1986, Minamisawa et al . 1990) and rats (Reyners et al 1992) . In addition, a behavioural study (Kimler and Norton 1988) reported a no-threshold linear relationship for radiation-induced decrements in exploratory behaviour (measured by activity in a continuous corridor apparatus on postnatal day 21) for rats exposed on day 15 pc to y-radiation at between 0 .…”

Section: Discussionmentioning

confidence: 94%

Prenatal Irradiation and Spatial Memory in Mice: Investigation of Dose-response Relationship

Sienkiewicz¹,

Haylock²,

Saunders³

1994

International Journal of Radiation Biology

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Pregnant CD1 mice were exposed on gestational day 18 to 250 kV X-rays at 0.1, 0.25, 0.35 and 0.5 Gy. The performances of 10 adult male offspring from each exposure condition were investigated on a spatial discrimination learning task in a radial arm maze. An impairment in the performance of this task was found which showed a correlation with dose. Compared with sham exposed control mice, performance was not significantly affected with irradiation at 0.1 Gy and was slightly but non-significantly reduced at 0.25 Gy. Irradiation at 0.35 Gy caused a significant impairment in performance, and exposure at 0.5 Gy resulted in a still larger impairment. The overall association between dose and behavioural impairment was best described by a linear relationship without a threshold, although at doses lower than about 0.25 Gy any impairment would appear to be too small to be detectable.

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Brain Atrophy after Foetal Exposure to Very Low Doses of Ionizing Radiation

Cited by 30 publications

References 11 publications

Late effect of prenatal irradiation on the hippocampal histology and brain weight in adult mice

Late effect of prenatal irradiation on the hippocampal histology and brain weight in adult mice

Radioprotection by plant products: present status and future prospects

Prenatal Irradiation and Spatial Memory in Mice: Investigation of Dose-response Relationship

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