“…Interestingly, water intake was increased in PV3-treated WT and as expected, rats intaking more water had increases in urinary volume. This suggests that PV3 was unable to affect drinking behavior in the hypertensive condition, already known for being altered in the SHR ( Sales da Silva et al, 2020 ) strain that is well reported as an experimental model with modifications in health status ( Dickhout and Lee, 1998 ). On the other hand, it is worth suggesting that PV3 preserves the drinking capacity of normotensive animals, since the changes in arterial pressure linked to diminishments in blood volume and to augmentations in urinary excretion caused by PV3 are expected to produce the dipsogenic responses we found ().…”