Brain and kidney GHS-R1a underexpression is associated with changes in renal function and hemodynamics during neurogenic hypertension

A peptide fraction from hardened common beans (Phaseolus vulgaris) induces endothelium-dependent antihypertensive and renal effects in rats

“…Interestingly, water intake was increased in PV3-treated WT and as expected, rats intaking more water had increases in urinary volume. This suggests that PV3 was unable to affect drinking behavior in the hypertensive condition, already known for being altered in the SHR ( Sales da Silva et al, 2020 ) strain that is well reported as an experimental model with modifications in health status ( Dickhout and Lee, 1998 ). On the other hand, it is worth suggesting that PV3 preserves the drinking capacity of normotensive animals, since the changes in arterial pressure linked to diminishments in blood volume and to augmentations in urinary excretion caused by PV3 are expected to produce the dipsogenic responses we found ().…”

“…WT and SHR (250g–350g) were distributed into 4 groups (n = 8 animals per group, according to their treatments) and housed in individual metabolic cages, with water and food ad libitum, similar to the used in our previous studies ( Rodrigues et al, 2022 ; Sales da Silva et al, 2020 ). After 24 h of adaptation, water and food were replaced for experimental analysis.…”