Brain acute ischemia mechanisms: implications to experimental and clinical treatment

Ivanov, Evgeniy V.; Гаврилова, С.А.; Koshelev, V. B.

doi:10.24884/1682-6655-2021-20-2-5-19

Cited by 5 publications

(2 citation statements)

References 143 publications

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“…Энергетические потребности мозга и отдельных нейронов каждую секунду целиком зависят от притока крови. Поэтому для нормальной работы мозга необходима жесткая синхронность между потреблением энергии нейронами и региональным кровотоком [4]. Один из возможных механизмов, обеспечивающих эту синхронность, был найден при использовании современных методов визуализации движений крови в микрососудах и диффузии кислорода в ткани мозга, анализа и обобщения данных математическими моделями.…”

Section: постановка проблемыunclassified

The cognitive stability of an elderly human is guaranteed by his lifelong motor activity

Radchenko

2023

Psychopharmacology & biological narcology

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A persons muscular activity, or behavior when performing various types of physical exercises, is determined by the brains complex, multi-level architectonics. The organization of any type of movement in sports and physical exercises, as well as various types of professional motor activity, involves all levels of the central nervous system. This study aims to analyze the benefits of sports for maintaining long-term brain activity. This study conducted literary critical analysis of the functional interaction of various cortical and subcortical mechanisms of human voluntary movements with domestic and foreign literature involvement. Regular sports cause structural changes in areas of the brain that are directly or indirectly involved in the organization of movements. Moreover, due to an increase in perfusion, a significant part of the gray matter of the primary sensorimotor fields and many associative areas of the cortex are also subject to structural changes. Muscle work and any motor activity are a positive factor that determines a persons cognitive stability in old age due to favorable changes in the brain. This conclusion refutes the popular belief that long-term sports lead to the preservation of only the motor cortex with age, whereas the capillary networks in other areas, particularly associative fields, occlude earlier with age, and impair intelligence.

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Section: постановка проблемыunclassified

The cognitive stability of an elderly human is guaranteed by his lifelong motor activity

Radchenko

2023

Psychopharmacology & biological narcology

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“…Ischemia and trauma of the brain and spinal cord are characterized by primary injury and subsequent secondary phase of injury [58,64,65]. A critical component of secondary injury is oxidative stress and increased formation of reactive oxygen species [27,66].…”

Section: Introductionmentioning

confidence: 99%

Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

Andrianov,

Kulchitsky,

Yafarova

et al. 2023

Molecules

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Nitric oxide (NO) production in injured and intact brain regions was compared by EPR spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of the brain was injured, followed by the spinal cord at the level of the first lumbar vertebra. Seven days after brain injury, a reduction in NO content of 84% in injured brain regions and 66% in intact brain regions was found. The difference in NO production in injured and uninjured brain regions persisted 7 days after injury. The copper content in the brain remained unchanged one week after modeling of brain and spinal cord injury. The data obtained in the experiments help to explain the problems in the therapy of patients with combined brain injury.

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An EPR Spectroscopy Study of NO and Copper Content in Injured and Uninjured Areas of the Brain After a Combined Injury of the Brain and Spinal Cord in Rats

Andrianov,

Kulchitsky,

Yafarova

et al. 2023

Preprint

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Here we performed a comparative experimental analysis by EPR spectroscopy of the intensity of nitric oxide (NO) production and copper content in the injured and uninjured areas of the frontal lobes and the hippocampus of the brain of male Wistar rats, after modeling of combined brain and spinal cord injury. Brain and spinal cord injury were modelled by local destruction of the left precentral region of the brain using a stylet followed by hemorrhage injury at the level of the first lumbar vertebra of the spinal cord. We found a significant decrease in NO production 7 days after injury modeling in the injured and uninjured (contralateral) brain regions, but the copper content remained unchanged one week after injury modeling. Thus, combined brain and spinal cord injury is not accompanied by a radical change in the activity of the antioxidant system in the brain, which is also confirmed by the absence of changes in NO production and copper content in the hippocampus.

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Brain acute ischemia mechanisms: implications to experimental and clinical treatment

Cited by 5 publications

References 143 publications

The cognitive stability of an elderly human is guaranteed by his lifelong motor activity

The cognitive stability of an elderly human is guaranteed by his lifelong motor activity

Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

An EPR Spectroscopy Study of NO and Copper Content in Injured and Uninjured Areas of the Brain After a Combined Injury of the Brain and Spinal Cord in Rats

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