Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia

Bavel, Jay J. Van; Bergé, Daniel; Guell, Xavier; Pérez, Ví­ctor; Vilarroya, Óscar

doi:10.1007/s00406-020-01145-8

Cited by 3 publications

(10 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our task this reward maximization strategy may be successful even when effort cannot consistently be maintained, because participants received the default reward of 1 CHF in failed trials. However, in both our task, and that of Pretus et al, 44 reward maximization in patients was not observed: in the former we find no difference between patients and controls in the amount won, and in the latter patients ended up with lesser total gains than controls.…”

Section: Discussioncontrasting

confidence: 65%

“…A recent study using an effort-based task (in the form of button presses) in patients with SZ and HC participants has also reported that patients made high-effort choices irrespective of the reward amount they could win (1 euro vs 1 cent). 44 It thus appears that in certain circumstances patients with SZ tend to disregard effort to maximize reward. This strategy may appear rational, as indeed, if the high effort can be maintained throughout the task, this should result in maximizing reward.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Associations Between Negative Symptoms and Effort Discounting in Patients With Schizophrenia and Major Depressive Disorder

Cathomas

Klaus

Guetter

et al. 2021

Schizophrenia Bulletin Open

View full text Add to dashboard Cite

Deficits in goal-directed decision making and motivation are hallmark characteristics of several neuropsychiatric disorders, including schizophrenia (SZ) and major depressive disorder (MDD). Studies using effort based decision making tasks have shown that both patients with SZ and MDD invest less physical effort in order to obtain rewards. However, how these motivational deficits relate to clinically assessed symptom dimensions such as apathy remains controversial. Using a grip-strength based effort discounting task we assessed effort based decision making behaviour in healthy controls (HC) (N = 18), patients with SZ (N = 42) and MDD (N = 44). We then investigated how effort discounting relates to different symptom dimensions. There were no differences in effort discounting between HC participants and patients with SZ or MDD. In addition, we did not observe a correlation between effort discounting and negative symptoms in patients with SZ or MDD. In conclusion, the current study does not support an association between effort discounting and negative symptoms in SZ or MDD. Further studies are needed to investigate effort discounting and its relation to psychopathological dimensions across different neuropsychiatric disorders.

show abstract

Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Associations Between Negative Symptoms and Effort Discounting in Patients With Schizophrenia and Major Depressive Disorder

Cathomas

Klaus

Guetter

et al. 2021

Schizophrenia Bulletin Open

View full text Add to dashboard Cite

show abstract

“…For example, those with early psychosis were less likely to select the high-effort, high-reward options than healthy control subjects ( 94 ). Furthermore, in a task in which increasing the effort improved the chance of receiving a high or low reward, people with schizophrenia were willing to expend the same effort regardless of reward size, whereas healthy individuals heavily biased their effort to increase the chance of higher rewards ( 95 ). This was associated with reduced functional changes in the caudate and anterior cingulate cortex during reward presentation and in the caudate during effort selection.…”

Section: Reward Processing In Psychosismentioning

confidence: 99%

Neural Circuitry of Salience and Reward Processing in Psychosis

Kesby

Murray

Knolle

2023

Biological Psychiatry Global Open Science

View full text Add to dashboard Cite

“…The primary search yielded 1592 studies published between 1971 and 2021 (Figure 1). Overall, 20 references had usable data and were included in the meta-analysis . Studies represented a total of 1503 participants, of whom 666 were controls (306 [45.9%] female; 360 [54.1%] male; mean [SD] age, 34.16 [5.92] years) and 837 had schizophrenia (296 [35.4%] female; 541 [64.6%] male; mean [SD] age, 35.89 [6.70] years).…”

Section: Resultsmentioning

confidence: 99%

“…Another controversial issue is the confounding effect of antipsychotic medications on effort-cost computation. Multiple studies found no correlation between antipsychotic dose and willingness to exert effort, while one study found a positive association; this is surprising given the implication of acute striatal dopamine D 2 blockade in reducing goal-directed behavior …”

Section: Introductionmentioning

confidence: 95%

Effort-Cost Decision-making Among Individuals With Schizophrenia

et al. 2023

View full text Add to dashboard Cite

ImportanceMotivational impairments in schizophrenia are by definition associated with poor outcome. It is postulated that the reduction of goal-directed behavior arises from abnormal trade-offs between rewards and efforts.ObjectiveTo examine whether schizophrenia is associated with impairments in effort-cost decision-making.Data SourcesFor this systematic review and meta-analysis, the PubMed, ScienceDirect, PsycINFO, Embase, and ClinicalTrials.gov databases were searched from inception to July 2022 for studies that investigated effort-cost decision-making in schizophrenia. Search terms included effort, cost, and schizophrenia.Study SelectionConsensual criteria for inclusion were peer-reviewed studies published in English that used a computerized effort-cost decision-making behavioral paradigm and compared individuals with schizophrenia with control individuals.Data Extraction and SynthesisThe Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline was used for abstracting data. Data were extracted independently by 2 authors and then pooled using random-effects sizes and bayesian approaches.Main Outcomes and MeasuresThe main outcomes were performance on effort-cost decision-making tasks requiring an effort-reward trade-off, measured by Hedges g effect size. Effects of moderators were tested with meta-regressions and subgroup analyses.ResultsTwenty studies involving 1503 participants were included: 837 individuals with schizophrenia (541 [64.6%] male; mean [SD] age, 35.89 [6.70] years) and 666 control individuals without schizophrenia (360 [54.1%] male; mean [SD] age, 34.16 [5.92] years). Participants with schizophrenia had significantly reduced willingness to expend effort for rewards compared with controls (k = 20; effect size, 0.43; 95% CI, 0.30-0.56; P &lt; .001; I2 = 33.1%; Q test P = .08). The magnitude of the deficit was significantly greater for high-reward trials. The severity of negative symptoms was negatively associated with effort-cost decision-making (k = 8; effect size, −0.33; 95% CI, −0.50 to −0.15; P &lt; .001), while participants with a high number of negative symptoms had a significantly larger impairment in effort-cost decision-making (k = 5; effect size, 0.47; 95% CI, 0.10-0.84; P = .01).Conclusions and RelevanceIn this systematic review and meta-analysis, schizophrenia was associated with deficits in effort allocation as indexed by effort-cost decision-making tasks. Understanding the cognitive and neurobiological mechanisms driving effort allocation impairments may assist in developing novel interventions.

show abstract

Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia

Abstract: Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia

Cited by 3 publications

References 54 publications

Associations Between Negative Symptoms and Effort Discounting in Patients With Schizophrenia and Major Depressive Disorder

Associations Between Negative Symptoms and Effort Discounting in Patients With Schizophrenia and Major Depressive Disorder

Neural Circuitry of Salience and Reward Processing in Psychosis

Effort-Cost Decision-making Among Individuals With Schizophrenia

Contact Info

Product

Resources

About