BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1

Zhang, Zhixin; Liu, Zhiqiang; Jiang, Biwang; Lu, Xinyang; Ning, Xiaofei; Yuan, Chuan-Tao; Wang, Ailiang

doi:10.1016/j.bbrc.2015.07.158

Cited by 81 publications

(76 citation statements)

References 25 publications

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“…BRAF-activated nonprotein coding RNA (BANCR) is a 693 bp long transcript, which could promote the proliferation of gastric cancer cells via regulating NF-κB [14]. Recent studies indicate that up-regulation of BANCR correlates with tumor progression in ESCC [15,16,26], which is consistent with our results (Figure 1) that demonstrated that BANCR expression was positively correlated with the progression of ESCC.…”

Section: Bancr Expression Affects the Growth Of Escc Cellssupporting

confidence: 82%

BRAF-activated non-protein coding RNA (BANCR) advances the development of esophageal squamous cell carcinoma via cell cycle

Yang¹,

Wang²,

Chen

et al. 2017

Open Life Sciences

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Esophageal carcinoma is one of the important lethal tumors in the world, but the mechanism of esophageal cancer progression is still unclear. The long non-coding RNAs are known to regulate tumor progression. Here we report that BRAF-activated nonprotein coding RNA (BANCR) is associated with the development of esophageal squamous cell carcinoma (ESCC). The expression levels of BANCR in 132 ESCC tumor tissues detected by quantitative real-time PCR were significantly higher than that in the adjacent normal tissues. The expression level of BANCR was down-regulated by transfecting small interrupting RNA against BANCR (BANCR siRNA) in Eca109 cells. Eca109 and TE-1 cells transfected with BANCR siRNA led to the delayed cell cycles compared to the cells transfected with negative control siRNA. Moreover, MTT assays demonstrated that Eca109 cells transfected with BANCR siRNA resulted in the inhibition of cell proliferation. These results suggested that BANCR advances the development and progression of ESCC cells through regulating their cell cycles.

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Section: Bancr Expression Affects the Growth Of Escc Cellssupporting

confidence: 82%

BRAF-activated non-protein coding RNA (BANCR) advances the development of esophageal squamous cell carcinoma via cell cycle

Yang¹,

Wang²,

Chen

et al. 2017

Open Life Sciences

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“…BRAF-activated non-coding RNA (BANCR) is a lncRNA required for cell migration in different types of cancer (82–84). Shi et al investigated its contribution to colorectal cancer.…”

Section: Lncrnas Are Involved In P21 Pathway Regulation (Cdkn1a-p21)mentioning

confidence: 99%

Role of lncRNAs in Cellular Aging

Degirmenci

Sun

2016

Front. Endocrinol.

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Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence.

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“…BANCR promoted melanoma cell migration and played important role in the development and progression of gastric cancer [18], colorectal cancer [19], and lung cancer [20]. Little is known about the role of BANCR in EC.…”

Section: V600ementioning

confidence: 99%

Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway

Wang

et al. 2016

Cell Physiol Biochem

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Background/Aims: Microarray screening had found BRAF-activated non-coding RNA (BANCR) was significantly upregulated in type 1 endometrial cancer (EC). This study aimed to assess the potential role of long non-coding RNA (lncRNA) BANCR in the pathogenesis and progression of type 1 EC. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to confirm the expression of BANCR in type 1 EC tissue, and analyze its clinical significance. In vitro, RNA interference (siRNA) was used to investigate the biological role of BANCR in type 1 EC. Results: qRT-PCR revealed that the expression of lncRNA BANCR was higher in type 1 EC (P<0.01). BANCR expression was significantly correlated with FIGO stage, pathological grade, myometrial invasion, and lymph node metastasis. The expression of BANCR was significantly correlated with that of MMP2/MMP1. In vitro, knockdown of BANCR significantly suppressed proliferation, migration, and invasion of Ishikawa and HEC-1A cells, and significantly inhibited the ERK/MAPK signaling pathway that decreased MMP2 and MMP1 expression. Conclusion: BANCR is highly expressed in type 1 EC tissue and promotes EC-cell proliferation, migration, and invasion by activating ERK/MAPK signaling pathway that regulates MMP2/MMP1 expression. BANCR is expected to become a prognostic marker and therapeutic target in type 1 EC.

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BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1

Cited by 81 publications

References 25 publications

BRAF-activated non-protein coding RNA (BANCR) advances the development of esophageal squamous cell carcinoma via cell cycle

BRAF-activated non-protein coding RNA (BANCR) advances the development of esophageal squamous cell carcinoma via cell cycle

Role of lncRNAs in Cellular Aging

Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway

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