Microfluidic systems are now being designed with precision to execute increasingly complex tasks. However, their operation often requires numerous external control devices due to the typically linear nature of microscale flows, which has hampered the development of integrated control mechanisms. We address this difficulty by designing microfluidic networks that exhibit a nonlinear relation between applied pressure and flow rate, which can be harnessed to switch the direction of internal flows solely by manipulating input and/or output pressures. We show that these networks exhibit an experimentally-supported fluid analog of Braess's paradox, in which closing an intermediate channel results in a higher, rather than lower, total flow rate. The harnessed behavior is scalable and can be used to implement flow routing with multiple switches. These findings have the potential to advance development of built-in control mechanisms in microfluidic networks, thereby facilitating the creation of portable systems that may one day be as controllable as microelectronic circuits. † Microfluidics' promise to operate as autonomous microscale networks where fluids can be transported, mixed, reacted, separated, and processed is no longer limited by experimental fabrication challenges but instead by difficulties to create built-in controls [1][2][3]. The development of the modern microelectronics that form the basis of computer microprocessors was ultimately determined by the creation of integrated circuits, with all components fabricated on the same substrate. Microfluidics have already reached a level of integration in which networks with thousands of components, including control devices, are built on a single compact chip. However, in contrast with electronic integrated circuits, existing onchip fluid control devices still need to be actuated externally. For example, microfluidic circuits fabricated from flexible polydimethylsiloxane (PDMS) can now incorporate a large number of control valves, which nevertheless have to be operated using control fluids through a control layer that lays on top of the working fluid network [4,5]. As a result, microfluidics are still predominantly controlled by external hardware despite significant efforts over the past twenty years to develop systems with new control schemes [6][7][8][9][10]. The construction of systems that forgo the current reliance on external hardware is crucial to further the development of portable microfluidic systems for pressing applications, ranging from point-of-care diagnostics and health monitoring wearables to analysis kits for field research [11][12][13][14]. This requires developing next-generation integrated circuits in which not only the control devices but also the operation of those devices is integrated on-chip. The development of such a level of integration has been fundamentally limited by the fact that, at the microscale, fluid flows tend to respond lin- † The final version of this paper was published early to pressure changes and thus cannot be easily ampl...