Bradicardia sinusal asociada a la administración oral de mesalazina

Barquero-Romero, José; Arrobas-Vacas, Jesús; López-Santamaría, José Luis; López-Santamaría, Carolina

doi:10.1157/13087725

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…2 Mesalamine-induced sinus bradycardia has been reported in four cases so far. 3,4 In one case report, it was postulated to be due to an unrecognised unique predisposing factor like cardiac conduction abnormality unmasked by mesalamine use. 2 One other case report postulated a modulating effect on prostaglandin metabolism as the pathologic mechanism of bradycardia.…”

Section: Discussionmentioning

confidence: 99%

Drug-induced bradycardia

Patil

Shafiq

2023

Clinical Medicine

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A 45-year-old woman presented to the hospital with bloody diarrhoea and significant weight loss over the past 1 month. On admission and evaluation, she was found to have acute ulcerative colitis. She was started on prednisolone and mesalamine therapy. Within 24 hours of initiation of this therapy, the patient complained of giddiness and chest discomfort and was found to have sinus bradycardia on ECG with no acute coronary event. After withdrawing mesalamine, her heart rate normalised within 24 hours and she remained symptom-free. This is a rare case report of severe symptomatic sinus bradycardia due to mesalamine therapy; to our knowledge, only four cases of mesalamine-induced bradycardia have been reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Drug-induced bradycardia

Patil

Shafiq

2023

Clinical Medicine

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“…Sinus bradycardia has been reported earlier with mesalamine use [ 3 , 9 ]. Since the patient has had mesalamine in the past, a predisposing factor must be present which promotes bradycardia.…”

Section: Discussionmentioning

confidence: 99%

Mesalamine Associated Bradycardia

Krzyzak

Gupta

Antonov

et al. 2018

Cureus

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A 38-year-old female presented with an acute flare of ulcerative colitis. She was started on prednisone and mesalamine. Within 24 hours of initiating mesalamine, she developed sinus bradycardia. After holding mesalamine, the heart rate returned to normal within five days. Our case illustrates the third described case, to our knowledge, of severe sinus bradycardia secondary to mesalamine.

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Current awareness: Pharmacoepidemiology and drug safety

2006

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Bradicardia sinusal asociada a la administración oral de mesalazina

Cited by 5 publications

References 10 publications

Drug-induced bradycardia

Drug-induced bradycardia

Mesalamine Associated Bradycardia

Current awareness: Pharmacoepidemiology and drug safety

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