Mesalamine Associated Bradycardia

Krzyzak, Michael; Gupta, Anupam; Antonov, E. K.; Mulrooney, Stephen

doi:10.7759/cureus.2425

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 One other case report postulated a modulating effect on prostaglandin metabolism as the pathologic mechanism of bradycardia. 5 Another case report postulated mesalamineinduced myocarditis as the cause for bradycardia. However, there is inadequate evidence to identify the mechanism through which mesalamine causes bradycardia.…”

Section: Discussionmentioning

confidence: 99%

Drug-induced bradycardia

Patil

Shafiq

2023

Clinical Medicine

View full text Add to dashboard Cite

A 45-year-old woman presented to the hospital with bloody diarrhoea and significant weight loss over the past 1 month. On admission and evaluation, she was found to have acute ulcerative colitis. She was started on prednisolone and mesalamine therapy. Within 24 hours of initiation of this therapy, the patient complained of giddiness and chest discomfort and was found to have sinus bradycardia on ECG with no acute coronary event. After withdrawing mesalamine, her heart rate normalised within 24 hours and she remained symptom-free. This is a rare case report of severe symptomatic sinus bradycardia due to mesalamine therapy; to our knowledge, only four cases of mesalamine-induced bradycardia have been reported in the literature.

show abstract

Section: Discussionmentioning

confidence: 99%

Drug-induced bradycardia

Patil

Shafiq

2023

Clinical Medicine

View full text Add to dashboard Cite

show abstract

“…The potential side effects related to mesalazine use, and their frequency, were analysed using review, studies and clinical cases. Their table 4 shows that cardiac adverse events are reported with a frequency of 0%‐0,3%, including cardiomyopathy, myocardial infarction, atrio‐ventricular block and ventricular dysfunction, but no mention is made about sinus bradycardia, a side effect which can rarely occur during mesalazine use and that has been described only by four clinical cases in the literature . In three of four cases, the patients were young women who had developed symptoms early after starting mesalazine treatment.…”

mentioning

confidence: 99%