Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2’-O-methylation modification of Bim

Bao, Hai‐Juan; Chen, Xi; Liu, Xin; Wu, Wu; Li, Qianhui; Xian, Jing-Yuan; Zhao, Yang; Chen, Shuo

doi:10.1038/s41420-022-01102-5

Cited by 17 publications

(14 citation statements)

References 37 publications

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“…18 SNORD89 regulates 2′-Omethylation of Bim mRNA, leading to reduced Bim protein levels by inhibiting translation. 19 These results are consistent with a previous study showing that 2′-O-methylation of synthetic mRNAs interferes with translation elongation and induces site-specific ribosome stalling in vitro. 20 In contrast, SNORD104 enhances PARP1 mRNA stability and translation in endometrial cancer cells by installing 2′-O-methylation on PARP1 mRNA, thereby promoting tumor growth.…”

Section: Rna-guided 2′-o-methylationsupporting

confidence: 93%

“…For instance, Snord32a and Snord51 cooperatively 2′- O -methylate Pxdn mRNA in mice, stabilizing its mRNA level but inhibiting its translation . SNORD89 regulates 2′- O -methylation of Bim mRNA, leading to reduced Bim protein levels by inhibiting translation . These results are consistent with a previous study showing that 2′- O -methylation of synthetic mRNAs interferes with translation elongation and induces site-specific ribosome stalling in vitro .…”

Section: The Biogenesis and Functions Of Rna-guided Rna Modificationssupporting

confidence: 88%

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RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications

Li,

Qu,

Yang

2023

Acc. Chem. Res.

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Section: Rna-guided 2′-o-methylationsupporting

confidence: 93%

Section: The Biogenesis and Functions Of Rna-guided Rna Modificationssupporting

confidence: 88%

RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications

Li,

Qu,

Yang

2023

Acc. Chem. Res.

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“…It has been reported that SNORA71A promotes breast cancer metastasis by stabilizing ROCK2 mRNA through binding with the G3BP protein [ 11 ]. SNORD89 upregulation in endometrial cancer inhibits Bim and suppresses the apoptosis of endometrial cancer cells by binding to fibrillarin (Fbl) [ 6 ]. SNORD17 facilitates hepatocellular carcinoma (HCC) progression by anchoring nucleophosmin 1 (NPM1) and MYB binding protein 1a (MYBBP1A) in the nucleolus, leading to p53 inhibition [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence has indicated the role of snoRNAs in the pathology of various cancers. As an epigenetic regulator, abnormally expressed snoRNAs can activate or inhibit cancer-related signalling pathways by regulating target genes and altering cell biological behaviors, thereby regulating the proliferation, self-renewal and metastasis of cancer cells and affecting tumorigenesis [ 6 – 8 ]. For example, SNORD33, SNORD66 and SNORD76 are highly expressed in the tissues and plasma of lung cancer patients and can be used as potential prognostic markers [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression

Zhang,

Song,

Jin

et al. 2024

Breast Cancer Res

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Background Small nucleolar RNAs (snoRNAs) play key roles in ribosome biosynthesis. However, the mechanism by which snoRNAs regulate cancer stemness remains to be fully elucidated. Methods SNORA68 expression was evaluated in breast cancer tissues by in situ hybridization and qRT‒PCR. Proliferation, migration, apoptosis and stemness analyses were used to determine the role of SNORA68 in carcinogenesis and stemness maintenance. Mechanistically, RNA pull-down, RNA immunoprecipitation (RIP), cell fractionation and coimmunoprecipitation assays were conducted. Results SNORA68 exhibited high expression in triple-negative breast cancer (TNBC) and was significantly correlated with tumor size (P = 0.048), ki-67 level (P = 0.037), and TNM stage (P = 0.015). The plasma SNORA68 concentration was significantly lower in patients who achieved clinical benefit. The SNORA68-high patients had significantly shorter disease-free survival (DFS) (P = 0.036). Functionally, SNORA68 was found to promote the cell stemness and carcinogenesis of TNBC in vitro and in vivo. Furthermore, elevated SNORA68 expression led to increased nucleolar RPL23 expression and retained RPL23 in the nucleolus by binding U2AF2. RPL23 in the nucleolus subsequently upregulated c-Myc expression. This pathway was validated using a xenograft model. Conclusion U2AF2-SNORA68 promotes TNBC stemness by retaining RPL23 in the nucleolus and increasing c-Myc expression, which provides new insight into the regulatory mechanism of stemness.

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“…In endometrial cancer, the box C/D snoRNA SNORD89 expression level is higher in patients with lymph node metastasis than those without lymph node involvement. Furthermore, SNORD89 overexpression promotes cell migration and inhibits BIM mRNA translation through higher activity of 2 Ome, thus dysregulating the Bim/Bcl2/Bax signalling pathway leading also to apoptosis inhibition [100]. In breast cancer, SNORA71A is highly expressed in metastatic breast cancer tissues compared to non-metastatic samples.…”

Section: Mirna and Snorna Expression In Cancer Cells And Their Roles ...mentioning

confidence: 99%

MiRNAs and snoRNAs in Bone Metastasis: Functional Roles and Clinical Potential

Puppo

Jaafar

Diaz

et al. 2022

Cancers

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Bone is a frequent site of metastasis. Bone metastasis is associated with a short-term prognosis in cancer patients, and current treatments aim to slow its growth, but are rarely curative. Thus, revealing molecular mechanisms that explain why metastatic cells are attracted to the bone micro-environment, and how they successfully settle in the bone marrow—taking advantage over bone resident cells—and grow into macro-metastasis, is essential to propose new therapeutic approaches. MicroRNAs and snoRNAs are two classes of small non-coding RNAs that post-transcriptionally regulate gene expression. Recently, microRNAs and snoRNAs have been pointed out as important players in bone metastasis by (i) preparing the pre-metastatic niche, directly and indirectly affecting the activities of osteoclasts and osteoblasts, (ii) promoting metastatic properties within cancer cells, and (iii) acting as mediators within cells to support cancer cell growth in bone. This review aims to highlight the importance of microRNAs and snoRNAs in metastasis, specifically in bone, and how their roles can be linked together. We then discuss how microRNAs and snoRNAs are secreted by cancer cells and be found as extracellular vesicle cargo. Finally, we provide evidence of how microRNAs and snoRNAs can be potential therapeutic targets, at least in pre-clinical settings, and how their detection in liquid biopsies can be a useful diagnostic and/or prognostic biomarker to predict the risk of relapse in cancer patients.

show abstract

Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2’-O-methylation modification of Bim

Cited by 17 publications

References 37 publications

RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications

RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications

U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression

MiRNAs and snoRNAs in Bone Metastasis: Functional Roles and Clinical Potential

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