RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications

Li, Bin; Qu, Lianghu; Yang, Jianhua

doi:10.1021/acs.accounts.3c00474

Cited by 4 publications

(2 citation statements)

References 78 publications

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“…RNA methylation modifications mainly include N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), and pseudouridine (Ψ) [ 40 – 42 ]. RNA methylation is observed to exist in all types of RNA, such as messenger RNA (mRNA), transfer RNA (tRNA), and noncoding RNA (ncRNA) [ 43 – 46 ]. These modifications involve regulating various aspects of targeted RNA processing, including RNA transcriptome processing, splicing, and export [ 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of RNA methylation in hepatocellular carcinoma

Bao,

Zeng,

Lou

et al. 2024

Cell Commun Signal

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Hepatocellular carcinoma (HCC) is a primary liver malignancy with high mortality rates and poor prognosis. Recent advances in high-throughput sequencing and bioinformatic technologies have greatly enhanced the understanding of the genetic and epigenetic changes in liver cancer. Among these changes, RNA methylation, the most prevalent internal RNA modification, has emerged as a significant contributor of the development and progression of HCC. Growing evidence has reported significantly abnormal levels of RNA methylation and dysregulation of RNA-methylation-related enzymes in HCC tissues and cell lines. These alterations in RNA methylation play a crucial role in the regulation of various genes and signaling pathways involved in HCC, thereby promoting tumor progression. Understanding the pathogenesis of RNA methylation in HCC would help in developing prognostic biomarkers and targeted therapies for HCC. Targeting RNA-methylation-related molecules has shown promising potential in the management of HCC, in terms of developing novel prognostic biomarkers and therapies for HCC. Exploring the clinical application of targeted RNA methylation may provide new insights and approaches for the management of HCC. Further research in this field is warranted to fully understand the functional roles and underlying mechanisms of RNA methylation in HCC. In this review, we described the multifaceted functional roles and potential mechanisms of RNA methylation in HCC. Moreover, the prospects of clinical application of targeted RNA methylation for HCC management are discussed, which may provide the basis for subsequent in-depth research on RNA methylation in HCC.

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Section: Introductionmentioning

confidence: 99%

Clinical significance of RNA methylation in hepatocellular carcinoma

Bao,

Zeng,

Lou

et al. 2024

Cell Commun Signal

View full text Add to dashboard Cite

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“…组成型非编码RNA包括转运RNA (transfer RNA, tRNA)、核糖体RNA(ribosomal RNA, rRNA)、小核RNA(small nuclear RNA, snRNA)等. 调控型ncRNA则包括长非编码RNA(long non-coding RNA, lncRNA) [6] 、环状RNA(circular RNA, cir-cRNA) [7] 、微小RNA(microRNA, miRNA)、PIWI蛋白互作RNA(Piwi-interacting RNA, piRNA) [8] 、小核仁 RNA(small nucleolar RNA, snoRNA) [9] 等多种类型, 且 (expert system, ES, 或由多个rule-based algorithm所构成) [13,14] 、机器学习(machine learning, ML) [15] 、深度学习(deep learning, DL) [16] 等(图2), 还总结了它们在 1.1 lncRNA鉴定 lncRNA是指长度超过200个核苷酸的线性RNA分子, 不具备编码蛋白质的能力且具有组织/细胞类型特异性 [6] . 根据lncRNA与编码序列的相对位置, 其可细分为如图3A lncRNA的多种类型.…”

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