Bowenoid <i>in situ</i> carcinomas in two Devon Rex cats: evidence of unusually aggressive neoplasm behaviour in this breed and detection of papillomaviral gene expression in primary and metastatic lesions

Munday, John S.; Benfell, Mike W.; French, Adrienne F.; Orbell, Geoff; Na, Thomson

doi:10.1111/vde.12319

Cited by 17 publications

(20 citation statements)

References 13 publications

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“…In many PV-induced neoplasms in other species, evidence that a PV may be involved in cancer development can also be derived from the observation that PV-induced lesions can progress to neoplasia. Such progression is seen in cats where pre-neoplastic BISCs, which often show histological evidence of PV infection, such as blue-grey cytoplasmic inclusions and koilocytosis [26], progress to invasive SCCs [27,28]. Likewise, in dogs, invasive carcinomas, albeit rarely, have developed as a progression from a cutaneous viral plaque or oral papilloma [29,30,31,32].…”

Section: Discussionmentioning

confidence: 99%

Papillomavirus DNA is not Amplifiable from Bladder, Lung, or Mammary Gland Cancers in Dogs or Cats

Munday

MacLachlan²,

Perrott

et al. 2019

Animals

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Simple SummaryPapillomaviruses (PVs) are well established to cause genital and oral cancer in humans. Additionally, some evidence suggests that these viruses may also have a role in the development of human lung, breast, and bladder cancer. Recent studies have revealed that PVs can influence the development of some cancers in cats and, less frequently, in dogs. In the present study, 47 lung, mammary gland, and bladder cancers in dogs and 25 cancers in cats were evaluated for evidence of any role PVs may have in cancer development. Histology did not reveal any lesions suggestive of PV infection, and no PV DNA was amplified from any cancer. Therefore, these findings suggest that PVs do not frequently infect these tissues and are therefore unlikely to be significant factors in the development of lung, mammary gland, or bladder cancer in either dogs or cats.AbstractPapillomaviruses (PVs) cause around 5% of all human cancers, including most cervical cancers and around a quarter of all oral cancers. Additionally, some studies have suggested that PVs could cause a proportion of human lung, breast, and bladder cancers. As PVs have been associated with skin cancer in cats and, more rarely, dogs, it was hypothesized that these viruses could also contribute to epithelial cancers of the lung, mammary gland, and bladder of dogs and cats. Formalin-fixed paraffin-embedded samples of 47 canine and 25 feline cancers were examined histologically for evidence of PV infection. Additionally, three sets of consensus PCR primers were used to amplify PV DNA from the samples. No histological evidence of PV infection was visible in any of the cancers. DNA from a bovine PV type was amplified from one sample, while two different samples were found to contain human PV DNA. However, these were considered to be contaminants, and no canine or feline PV types were amplified from any of the cancers. These results suggest that PVs do not frequently infect the lung, mammary gland, or bladder of dogs and cats and therefore are unlikely to be significant factors in the development of cancers in these tissues.

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Section: Discussionmentioning

confidence: 99%

Papillomavirus DNA is not Amplifiable from Bladder, Lung, or Mammary Gland Cancers in Dogs or Cats

Munday

MacLachlan²,

Perrott

et al. 2019

Animals

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Section: Diseases Associated With Papillomaviruses In Catsmentioning

confidence: 99%

“…More aggressive treatment is suggested for Devon Rex and Sphynx cats due to the observation that BISCs can rapidly progress to metastatic SCCs in these breeds. 32,33…”

Section: Treatment Approachesmentioning

confidence: 99%

“…2,30,31 Devon Rex and the closely related Sphynx breeds of cat appear to develop BISCs at an earlier age than other breeds, and the BISCs that develop in these cats tend to be highly aggressive and can rapidly metastasise (see 'Case notes' on page 413). 32,33 Cutaneous squamous cell carcinomas SCCs are one of the most common skin cancers of cats and, while the role of UV light in cancer development cannot be disputed, there is increasing evidence that FcaPV-2 may also cause SCC development. This evidence includes the detection of PV DNA more frequently in SCCs than in non-SCC skin samples, 28,34 the detection and localisation of FcaPV-2 RNA within a proportion of SCCs but not samples of normal skin, 35 and the demonstration that FcaPV-2 proteins can influence neoplastic transformation of a cell.…”

Section: Feline Viral Plaques/bowenoid In Situ Carcinomasmentioning

confidence: 99%

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Novel viruses: Update on the significance of papillomavirus infections in cats

Munday

Sharp

Beatty

2018

Journal of Feline Medicine and Surgery

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Practical relevance: Prior to 1990 papillomaviruses (PVs) were not recognised to infect or cause disease in domestic cats. Since this time, the use of histology, immunohistochemistry and, more recently, molecular techniques has revealed that PVs almost certainly cause feline viral plaques and Bowenoid in situ carcinomas, oral papillomas and feline sarcoids. In addition, there is increasing evidence that PVs play a significant role in the development of feline cutaneous squamous cell carcinomas, one of the most common skin cancers of cats. Recent studies have also revealed that most cats are asymptomatically infected with PVs. This raises a critical question that is currently unanswered: why do only a small proportion of infected cats develop disease? In the future it may be possible to prevent PV-induced diseases by using a vaccine to prevent PV infection. Alternatively, novel therapies may be developed that prevent PVs from causing clinical disease by stimulating the host immune response. Clinical challenges: A recognition of the skin diseases caused by PVs is important to more accurately predict disease progression. Unfortunately, there are currently no non-surgical treatments that have been proven to be beneficial in cats and clinical management of PV-induced skin disease in cats can be challenging. Global importance: PVs have a worldwide distribution and negatively impact feline health and welfare globally. Audience: This review is aimed at clinicians, especially those who regularly treat cats with skin disease. The review will also be useful to oncologists and researchers who have an interest in how cancer develops in cats. Evidence base: In producing this update the authors have drawn on recently published peer-reviewed literature.

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“…An aggressive severe form of SCC in situ is reported in Devon Rex cats ( Figure 10), which presents with progressive lesions that develop from a young age; this condition has been associated with internal metastasis of papillomavirus-associated SCC. 36,37…”

Section: Hypercortisolismmentioning

confidence: 99%

Skin as a marker of general feline health: Cutaneous manifestations of systemic disease

Vogelnest

2017

Journal of Feline Medicine and Surgery

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Practical relevance: Although most skin lesions occur due to diseases primarily affecting the skin, some reflect important systemic diseases. Such lesions may relate directly to the systemic disease, or may occur due to secondary skin diseases that develop because of immunosuppression. Early recognition of skin changes as a marker of systemic disease will maximise patient outcomes. Clinical challenges: In older or clearly debilitated cats presenting with skin disease, the potential for underlying systemic disease is often readily apparent. Similarly, cats presenting with severe ulcerative or multifocal nodular skin lesions, or with concurrent signs of systemic illness, will more instinctively prompt systemic evaluation. More challenging is the cat presenting with alopecic, scaling, erythemic and/or mildly crusted skin disease, with or without pruritus; hypersensitivities and infectious dermatoses are the most common considerations, but occasionally systemic disease underlies the skin changes. Knowing when screening laboratory testing, body imaging or other systemic diagnostics are indicated is not always straightforward. Evidence base: This article reviews cutaneous presentations of systemic diseases reported in the veterinary literature, and discusses important differential diagnoses. The author draws on clinical experience, published data on disease prevalence and case evaluations, and expert opinions on approach to common systemic problems to provide guidance on when investigation for underlying systemic disease is most appropriate.

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Bowenoid in situ carcinomas in two Devon Rex cats: evidence of unusually aggressive neoplasm behaviour in this breed and detection of papillomaviral gene expression in primary and metastatic lesions

Cited by 17 publications

References 13 publications

Papillomavirus DNA is not Amplifiable from Bladder, Lung, or Mammary Gland Cancers in Dogs or Cats

Papillomavirus DNA is not Amplifiable from Bladder, Lung, or Mammary Gland Cancers in Dogs or Cats

Novel viruses: Update on the significance of papillomavirus infections in cats

Skin as a marker of general feline health: Cutaneous manifestations of systemic disease

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