Bowel wall MRI T1 relaxation estimates for assessment of intestinal inflammation in pediatric Crohn’s disease

Mahalingam, Neeraja; Tkach, Jean A.; Denson, Lee A.; Dillman, Jonathan R.

doi:10.1007/s00261-022-03560-y

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…However, different sequences have been developed to provide more information on the GI parenchyma, motility, or content, like fast imaging employing steady-state acquisition (FIESTA) imaging or T1 mapping. (77)(78)(79) This chapter will focus on these techniques and their application in this PhD thesis.…”

Section: Advanced Mri Techniquesmentioning

confidence: 99%

“…This technique yields images with a high signal-to-noise ratio and has shown high reproducibility. (88,89) While T1 mappings have been extensively utilized in the study of the myocardium,(90-92) studies of the GI systems have applied this technique in the assessment of liver steatosis,(93,94) intestinal inflammation, (77) and in the evaluation of intestinal watery content. (78)…”

Section: T1 Relaxation Mappingmentioning

confidence: 99%

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Pan-enteric imaging of the gastrointestinal tract: A magnetic resonance study

Bertoli

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Section: Advanced Mri Techniquesmentioning

confidence: 99%

Section: T1 Relaxation Mappingmentioning

confidence: 99%

Pan-enteric imaging of the gastrointestinal tract: A magnetic resonance study

Bertoli

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Quantitative MRI in children with Crohn’s disease – where do we stand?

Debnath,

Dillman

2024

Pediatr Radiol

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Crohn’s disease (CD) is a chronic inflammatory condition that affects the gastrointestinal tract, particularly the ileum and colon. This disease is characterized by recurrent bouts of intestinal inflammation with subsequent bowel wall damage, including scarring (i.e., fibrosis) and abnormal smooth muscle proliferation. MR enterography, an MRI examination tailored to assess the small bowel, is a first-line diagnostic tool for diagnosing CD in children, characterization and monitoring of disease severity and extent, and assessment of disease-related complications. To date, such MRI evaluations have been mostly qualitative, which can adversely impact diagnostic performance and inter-radiologist agreement. Quantitative MRI methods have been shown to aid in the evaluation of a variety of medical conditions and have been increasingly investigated in children and adults with CD. In CD, such objective techniques have been used to assist with diagnosis, assess treatment response, and characterize bowel wall histologic abnormalities. In the current work, we will review quantitative MRI methods for detecting and measuring intestinal active inflammation (MRI-based scoring systems, T1 relaxation mapping, diffusion-weighted imaging, intra-voxel incoherent motion, mesenteric phase contrast), bowel wall damage (magnetization transfer), and motility (quantitative cine imaging) in small bowel CD, with an emphasis on the pediatric population. Graphical Abstract

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