Prospective characterization of intestinal MRI intravoxel incoherent motion in pediatric and young adult patients with newly diagnosed small bowel Crohn’s disease

Alves, Vinicius de Padua V.; Mahalingam, Neeraja; Tkach, Jean A.; Towbin, Alexander J.; Imbus, Rebecca; Denson, Lee A.; Dillman, Jonathan R.

doi:10.1007/s00261-024-04318-4

Abdom Radiol

2024

DOI: 10.1007/s00261-024-04318-4

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Prospective characterization of intestinal MRI intravoxel incoherent motion in pediatric and young adult patients with newly diagnosed small bowel Crohn’s disease

Vinicius de Padua V. Alves,

Neeraja Mahalingam,

Jean A. Tkach

et al.

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Quantitative MRI in children with Crohn’s disease – where do we stand?

Debnath,

Dillman

2024

Pediatr Radiol

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Crohn’s disease (CD) is a chronic inflammatory condition that affects the gastrointestinal tract, particularly the ileum and colon. This disease is characterized by recurrent bouts of intestinal inflammation with subsequent bowel wall damage, including scarring (i.e., fibrosis) and abnormal smooth muscle proliferation. MR enterography, an MRI examination tailored to assess the small bowel, is a first-line diagnostic tool for diagnosing CD in children, characterization and monitoring of disease severity and extent, and assessment of disease-related complications. To date, such MRI evaluations have been mostly qualitative, which can adversely impact diagnostic performance and inter-radiologist agreement. Quantitative MRI methods have been shown to aid in the evaluation of a variety of medical conditions and have been increasingly investigated in children and adults with CD. In CD, such objective techniques have been used to assist with diagnosis, assess treatment response, and characterize bowel wall histologic abnormalities. In the current work, we will review quantitative MRI methods for detecting and measuring intestinal active inflammation (MRI-based scoring systems, T1 relaxation mapping, diffusion-weighted imaging, intra-voxel incoherent motion, mesenteric phase contrast), bowel wall damage (magnetization transfer), and motility (quantitative cine imaging) in small bowel CD, with an emphasis on the pediatric population. Graphical Abstract

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Quantitative MRI in children with Crohn’s disease – where do we stand?

Debnath,

Dillman

2024

Pediatr Radiol

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Prospective characterization of intestinal MRI intravoxel incoherent motion in pediatric and young adult patients with newly diagnosed small bowel Crohn’s disease

Cited by 1 publication

References 36 publications

Quantitative MRI in children with Crohn’s disease – where do we stand?

Quantitative MRI in children with Crohn’s disease – where do we stand?

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