Bovine viral diarrhea virus infection in wild boar

Milićević, Vesna; Maksimović-Zorić, Jelena; Veljović, Ljubiša; Kureljušić, Branislav; Savić, Božidar; Cvetojević, Đorđe; Jezdimirović, Nemanja; Radosavljević, Vladimir

doi:10.1016/j.rvsc.2018.05.018

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…Not only domestic pigs are a concern when it comes to Pestivirus infections since wild boar have been described as important reservoirs or transmitters of pathogens in nature due to their ability to reach long distances and transmit diseases to domestic swine. Other studies [ 45 , 46 , 47 ] have reported a low prevalence of BVDV in wild boar in Germany, the Czech Republic, and Eastern Serbia, respectively. Weber [ 19 ] was the first to detect BVDV RNA in wild boars’ blood samples, and Gatto [ 48 ] first reported the presence of anti-BVDV antibodies in Thayasuids.…”

Section: Data Collection From Backyard and Intensive Pig Herdsmentioning

confidence: 96%

Bovine Viral Diarrhea Virus: Recent Findings about Its Occurrence in Pigs

Oliveira

Mechler-Dreibi

Almeida

et al. 2020

Viruses

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Bovine viral diarrhea virus (BVDV) is an important pathogen belonging to the Pestivirus genus, Flaviviridae family, which comprises viral species that causes an economic impact in animal production. Cattle are the natural host of BVDV and the main source of infection for pigs and other animal species. Due to its antigenic and genetic similarity with other important pestiviruses such as Classical Swine Fever Virus (CSFV), several studies have been conducted to elucidate the real role of this virus in piglets, sows, and boars, not only in the field but also in experimental infections, which will be discussed in this paper. Although BVDV does not pose a threat to pigs as it does to ruminants, the occurrence of clinical signs is variable and may depend on several factors. Therefore, this study presents a survey of data on BVDV infection in pigs, comparing information on prevalence in different countries and the results of experimental infections to understand this type of infection in pigs better.

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Section: Data Collection From Backyard and Intensive Pig Herdsmentioning

confidence: 96%

Bovine Viral Diarrhea Virus: Recent Findings about Its Occurrence in Pigs

Oliveira

Mechler-Dreibi

Almeida

et al. 2020

Viruses

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“…Bovine viral diarrhoea viruses (BVDV), with positive, non-segment, single stranded RNA genome, comprise a heterogeneous group of viruses which belong to the genus Pestivirus , the Flaviviridae family [1]. BVDV is a globally-distributed virus and its infection has been detected not only in domesticated ruminants, but also in wild ruminants and wild boars [2–7]. It is responsible for numerous clinical disease syndromes in cattle and severe economic losses in the cattle industry.…”

Section: Introductionmentioning

confidence: 99%

RNA-Seq based transcriptome analysis during bovine viral diarrhoea virus (BVDV) infection

Liu

Liang

et al. 2019

BMC Genomics

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BackgroundBovine viral diarrhoea virus (BVDV) is the member of the genus Pestivirus within the Flaviviridae family and responsible for severe economic losses in the cattle industry. BVDV can employ ‘infect-and-persist’ strategy and ‘hit-and-run’ strategy to remain associated with hosts and thus contributes to BVDV circulation in cattle herds. BVDV have also evolved various strategies to evade the innate immunity of host. To further understand the mechanisms by which BVDV overcomes the host cell innate immune response and provide more clues for further understanding the BVDV-host interaction, in this descriptive study, we conducted a investigation of differentially expressed genes (DEGs) of the host during BVDV infection by RNA-Seq analysis.ResultsOur analysis identified 1297, 1732, 3072, and 1877 DEGs in the comparison groups mock vs. MDBK cells infected with BVDV post 2 h (MBV2h), mock vs. MBV6h, mock vs. MBV12h, and mock vs. MBV24h, respectively. The reproducibility and repeatability of the results were validated by RT-qPCR. Enrichment analyses of GO annotations and KEGG pathways revealed the host DEGs that are potentially induced by BVDV infection and may participate in BVDV-host interactions. Protein-protein interaction (PPI) network analyses identified the potential interactions among the DEGs. Our findings suggested that BVDV infection induced the upregulation of genes involved in lipid metabolism. The expression of genes that have antiviral roles, including ISG15, Mx1, OSA1Y, were found to be downregulated and are thus potentially associated with the inhibition of host innate immune system during BVDV infection. The expression levels of F3, C1R, KNG1, CLU, C3, FB, SERPINA5, SERPINE1, C1S, F2RL2, and C2, which belong to the complement and coagulation signalling cascades, were downregulated during BVDV infection, which suggested that the complement system might play a crucial role during BVDV infection.ConclusionIn this descriptive study, our findings revealed the changes in the host transcriptome expression profile during BVDV infection and suggested that BVDV-infection induced altering the host’s metabolic network, the inhibition of the expression of antiviral proteins and genes within the complement system might be contributed to BVDV proliferation. The above findings provided unique insights for further studies on the mechanisms underlying BVDV-host interactions.

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“…Almeida et al (2017) also detected BVDV-1 and BVDV-2 seropositive samples in non-technified rearing farms at the northeast of the state of São Paulo. Wild animals infected with BVDV are described as indicative of the presence of the virus in nearby herds located within a given region, although the role of tayassuids in the epidemiology of BVDV is unknown (Milićević 2018).…”

Section: Resultsmentioning

confidence: 99%

Serological survey of bovine viral diarrhea (BVDV-1), brucellosis, and leptospirosis in captive white-lipped peccaries (Tayassu pecari) from the Midwest region in Brazil

Gatto¹,

Santo²,

Storino³

et al. 2020

Austral j. vet. sci.

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The present study was conducted to assess the occurrence of anti-Brucella sp., anti-BVDV-1, and anti-Leptospira spp. antibodies from captive white-lipped peccary (Tayassu pecari). A cross-sectional survey was performed testing 100 serum samples collected in a commercial breeding herd. All samples were submitted to the acidified antigen test (AAT), virus neutralization test (VNT) and microscopic agglutination test (MAT) with live antigens. None of the samples tested agglutinated in the AAT screening test. In the VNT, 28 samples presented a cytotoxic effect and were excluded from the evaluation. For BVDV-1, only one sample (1/72; 1.38%) was positive, with antibody titers of 40. For leptospirosis, 9% (9/100) of the samples reacted to at least one of the 24 serovars tested, with 8% (8/100) positive for serovar Patoc and 1% (1/100) for serovar Grippotyphosa. The maximum titer observed was 100. The identification of antibodies against the serovars Patoc and Grippotyphosa suggests that the sampled individuals have been exposed to the pathogen at some point during their lifetime. Regarding BVDV-1, this may be the first serological survey to describe seropositive samples in tayassuids.

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Bovine viral diarrhea virus infection in wild boar

Cited by 12 publications

References 16 publications

Bovine Viral Diarrhea Virus: Recent Findings about Its Occurrence in Pigs

Bovine Viral Diarrhea Virus: Recent Findings about Its Occurrence in Pigs

RNA-Seq based transcriptome analysis during bovine viral diarrhoea virus (BVDV) infection

Serological survey of bovine viral diarrhea (BVDV-1), brucellosis, and leptospirosis in captive white-lipped peccaries (Tayassu pecari) from the Midwest region in Brazil

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