Bovine sire effects on daughters' in vitro blood neutrophil functions, lymphocyte blastogenesis, serum complement and conglutinin levels

Kehrli, Marcus E.; Weigel, K.A.; Freeman, A.E.; Thurston, John R.; Kelley, David H.

doi:10.1016/0165-2427(91)90028-b

Cited by 47 publications

(19 citation statements)

References 35 publications

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“…These observations led the authors to suggest that testing neutrophil functions in dairy bulls entering artificial insemination may provide a tool for selection against infectious diseases [206]. Significant sire progeny group differences in in vitro neutrophil migration, ingestion and production of oxygen radicals have been reported [76]. Unfortunately, heritability estimates of bactericidal activity and response to chemotactic factors were found to be low [43,44].…”

Section: Genetic Selectionmentioning

confidence: 99%

Innate immunity of the bovine mammary gland

2006

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-Understanding the immune defenses of the mammary gland is instrumental in devising and developing measures to control mastitis, the major illness of dairy ruminants. Innate immunity is an extremely broad field for investigation, and despite decades of research, our present knowledge of the innate defenses of the udder is incomplete. Yet, information is being gained on the recognition of pathogens by the mammary gland, and on several locally inducible defenses. The contribution of mammary epithelial cells to local defenses and to the mobilization of leucocytes is under growing scrutiny. Interactions of mastitis-causing bacteria such as Escherichia coli or Staphylococcus aureus and the mammary gland represents a suitable model for studies on innate immunity at an epithelium frontier. Powerful new research tools are radically modifying the prospects for the understanding of the interplay between the mammary gland innate defenses and mastitis-causing bacteria: genetic dissection of the immune response, microarray gene technology, transcriptomic methodologies and gene silencing by RNA interference will make possible the discovery of several of the key defense mechanisms which govern the susceptibility/resistance to mastitis at the molecular and genetic levels. It should then be possible to enhance the resistance of dairy ruminants to mastitis through immunomodulation and genetic improvement. mastitis / cattle / innate immunity / inflammation / milk

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Section: Genetic Selectionmentioning

confidence: 99%

Innate immunity of the bovine mammary gland

2006

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“…Immunity traits studied were mainly antibody response and functionality of neutrophils, which recruitment and activity are essential in the innate defence against udder infection [78,87]. Several authors [36,43,49] reported a significant sire effect of in vitro phagocytosis of blood neutrophils. Detilleux et al [19] found moderate heritabilities for migration (0.2 to 0.5) and phagocytosis (0.3-0.7) of neutrophils and for serum complement activity (0.4-0.5), using in vitro assays for 137 cows sampled three times around calving.…”

Section: Genetic Variability Of Immune Mechanisms Underlying Mastitismentioning

confidence: 99%

Genetics of resistance to mastitis in dairy cattle

2003

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-Genetic variability of mastitis resistance is well established in dairy cattle. Many studies focused on polygenic variation of the trait, by estimating heritabilities and genetic correlation among phenotypic traits related to mastitis such as somatic cell counts and clinical cases. The role of Major Histocompatibility Complex in the susceptibility or resistance to intrammamary infection is also well documented. Finally, development from molecular genome mapping led to accumulating information of quantitative trait loci (QTL) related to mastitis resistance and better understanding of the genetic determinism of the trait. From economic and genetic analyses, and according to welfare and food safety considerations and to breeders and consumer's concern, there is more and more evidence that mastitis should be included in breeding objective of dairy cattle breeds. Many countries have implemented selection for mastitis resistance based on linear decrease of somatic cell counts. Given biological questioning, potential unfavourable consequences for very low cell counts cows are regularly investigated. Improvement of selection accuracy for mastitis resistance is ongoing and includes: advances in modelling, optimal combination of mastitis related traits and associated predictors, such as udder morphology, definition of global breeding objective including production and functional traits, and inclusion of molecular information that is now available from QTL experiments. mastitis / somatic cell count / genetic parameter / QTL / breeding program / dairy cattle

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“…High levels of cortisol at calving have also been reported (Goff & Horst 1997) to act as powerful immunosuppressive agent. According to Kehrli et al (1991), overall effects of stress increased cortisol level, produced neutrophilia with decreased functional capacity of neutrophils and immunosuppression. As a result the cows become less resistant to mastitis and other infections around calving.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of neutrophil competence and activity of cows and buffaloes around peripartum

Pathan

Kaur

Mohanty

et al. 2014

Journal of Applied Animal Research

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To compare immune activities of neutrophils, blood samples were collected from 12 cows and 12 buffaloes on −15, −7, −5, −3, −2 and −1 days prepartum at calving and on 1, 2, 3, 5, 7 and 15 days postpartum. Plasma cortisol levels, phagocytic activity (PA), enzyme (elastase, collagenase and cathepsin G) levels and expression of TLR-2, TLR-4 and IL-8 were also studied. Blood total leukocyte counts and neutrophil percentage increased at calving and decreased faster in buffaloes. Neutrophil PA was significantly (P < 0.01) lower even up to two days post calving in cows. Cortisol levels were significantly (P < 0.01) higher in cows and negatively correlated with neutrophilic functions. Elastase was significantly (P < 0.01) higher in buffaloes. Collagenase levels were significantly (P < 0.01) higher in buffaloes at three days precalving. At 15 days precalving and 7 and 15 days postcalving, expression of TLR-2 gene was significantly (P < 0.01) higher in buffaloes. Expression of TLR-4 gene was significantly (P < 0.01) higher on days 7 and 15 postcalving in buffaloes. Expression of IL-8 was significantly (P < 0.01) higher on day 15 of postcalving in buffaloes. Increased blood neutrophilic function in buffaloes provides disease resistance to them around peripartum.

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Bovine sire effects on daughters' in vitro blood neutrophil functions, lymphocyte blastogenesis, serum complement and conglutinin levels

Cited by 47 publications

References 35 publications

Innate immunity of the bovine mammary gland

Innate immunity of the bovine mammary gland

Genetics of resistance to mastitis in dairy cattle

Comparative evaluation of neutrophil competence and activity of cows and buffaloes around peripartum

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