Bovine serum albumin-sodium alkyl sulfates bioconjugates as drug delivery systems

Benkő, Mária; Varga, Noémi; Sebők, Dániel; Bohus, Gabriella; Juhász, Ádám; Dékány, Imre

doi:10.1016/j.colsurfb.2015.04.018

Cited by 31 publications

(7 citation statements)

References 47 publications

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“…The integrated rate law of the first order reaction kinetic equation is a typically used formula which states that the change in concentration with respect to change in time is dependent only on the drug concentration (Benkő et al, 2015).…”

Section: Graphical Abstractmentioning

confidence: 99%

Preparation of novel tissue acidosis-responsive chitosan drug nanoparticles: Characterization and in vitro release properties of Ca2+ channel blocker nimodipine drug molecules

Janovák

Turcsányi

Bozó

et al. 2018

European Journal of Pharmaceutical Sciences

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The pH-responsive intelligent drug release facility of hydrophobically modified chitosan nanoparticles (Chit NPs) (d = 5.2 ± 1.1 nm) was presented in the case of poorly water soluble Ca channel blocker nimodipine (NIMO) drug molecules. The adequate pH-sensitivity, i.e. the suitable drug carrier properties of the initial hydrophilic Chit were achieved by reductive amination of Chit with hexanal (C-) and dodecanal (C-) aldehydes. The successful modifications of the macromolecule were evidenced via FTIR measurements: the band appearing at 1412 cm (CN stretching in aliphatic amines) in the cases of the hydrophobically modified Chit samples shows that the CN bond successfully formed between the Chit and the aldehydes. Hydrophobization of the polymer unambiguously led to lower water contents with lower intermolecular interactions in the prepared hydrogel matrix: the initial hydrophilic Chit has the highest water content (78.6 wt%) and the increasing hydrophobicity of the polymer resulted in decreasing water content (C-chit.: 74.2 wt% and C-chit.: 47.1 wt%). Furthermore, it was established that the length of the side chain of the aldehyde influences the pH-dependent solubility properties of the Chit. Transparent homogenous polymer solution was obtained at lower pH, while at higher pH the formation of polymer (nano)particles was determined and the corresponding cut-off pH values showed decreasing tendency with increasing hydrophobic feature (pH = 7.47, 6.73 and 2.49 for initial Chit, C-chit and C-chit, respectively). Next the poorly water soluble NIMO drug was encapsulated with the C-chit with adequate pH-sensitive properties. The polymer-stabilized NIMO particles with 10 wt% NIMO content resulted in stable dispersion in aqueous phase, the formation of polymer shell increased in the water solubility/dispersibility of the initial hydrophobic drug. According to the drug release experiments, we clearly confirmed that the encapsulated low crystallinity NIMO drug remained closed in the polymer NPs at normal tissue pH (pH = 7.4, PBS buffer, physiological condition) but at pH < 6.5 which is typical for seriously ischemic brain tissue, 93.6% of the available 0.14 mg/ml NIMO was released into the buffer solution under 8 h release time. According to this in vitro study, the presented pH-sensitive drug carrier system could be useful to selectively target ischemic brain regions characterized by acidosis, to achieve neuroprotection at tissue zones at risk of injury, without any undesirable side effects caused by systemic drug administration.

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Section: Graphical Abstractmentioning

confidence: 99%

Preparation of novel tissue acidosis-responsive chitosan drug nanoparticles: Characterization and in vitro release properties of Ca2+ channel blocker nimodipine drug molecules

Janovák

Turcsányi

Bozó

et al. 2018

European Journal of Pharmaceutical Sciences

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“…The studied nanosized protein-non steroidal anti-inflammatory (NSAID) composites were prepared according to the procedure published previously [19,20]. Briefly, 20 w/v% BSA was dissolved in 15 ml buffer solution (McIlvaine buffer, pH 3.0).…”

Section: Preparation Of Bsa-ibu Nanocomposite Particlesmentioning

confidence: 99%

Thermodynamic and kinetic characterization of pH-dependent interactions between bovine serum albumin and ibuprofen in 2D and 3D systems

Csapó

Juhász

Varga

et al. 2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…They can enhance the effectiveness of the active ingredients in cosmetics, pharmaceuticals, and agricultural products, as well as in biotechnological and other industrial processes (Cserháti et al, ; Mao et al, ). AS are also biologically active: they can bind to bioactive macromolecules (Benkő et al, ), altering their biological functions, and penetrating into cell fragments or enhancing the penetration of other active molecules into the cell (Kaur et al, ; Som et al, ).…”

Section: Introductionmentioning

confidence: 99%

Optimization and Applicability of a Novel Sensor for Potentiometric Determination of Anionic Surfactants

Samardžić

Petrušić

Hajduković

et al. 2018

J Surfact & Detergents

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Novel potentiometric sensors for anionic surfactant (AS) determination, with different percentages of tetraoctadecylammonium tetraphenylborate (TODA-TPB) as sensing materials and different electrolytes (sodium chloride, lithium chloride, sodium dodecyl sulfate (NaDS), sodium tetraphenylborate, sodium acetate, and potassium chloride) at varied concentration levels, were developed and compared. The sensor with best response characteristics was further characterized. It had a fast response time (5 s), a low signal drift (2.0 and 2.9 mV h −1 in a detergent solution and NaDS, respectively), a wide pH working range (3-11), and a longer lifetime of 6 months. This novel sensor was characterized with Nernstian response toward NaDS (−58.0 mV decade −1 of activity), a wide working range (1.3 Á 10 −7 -5 Á 10 −3 M), and a low limit of detection (1.0 Á 10 −7 M). It proved to be an accurate and reliable sensor for AS determination in multicomponent mixtures of AS and household wastewater using a potentiometric titration method. Nonionic surfactants, which are commonly mixed with AS in commercial products to obtain better properties of products, had an insignificant impact on AS determination.

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Bovine serum albumin-sodium alkyl sulfates bioconjugates as drug delivery systems

Cited by 31 publications

References 47 publications

Preparation of novel tissue acidosis-responsive chitosan drug nanoparticles: Characterization and in vitro release properties of Ca2+ channel blocker nimodipine drug molecules

Preparation of novel tissue acidosis-responsive chitosan drug nanoparticles: Characterization and in vitro release properties of Ca2+ channel blocker nimodipine drug molecules

Thermodynamic and kinetic characterization of pH-dependent interactions between bovine serum albumin and ibuprofen in 2D and 3D systems

Optimization and Applicability of a Novel Sensor for Potentiometric Determination of Anionic Surfactants

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