Bovine serum albumin functionalized blue emitting Ti3C2 MXene quantum dots as a sensitive fluorescence probe for Fe3+ ion detection and its toxicity analysis

Al-Duais, Mohammed A.; Mohammedsaleh, Zuhair M.; Al-Shehri, Hamza S.; Al-Awthan, Yahya S.; Bani-Atta, Suhair A.; Keshk, Ali A.; Mustafa, S.; Althaqafy, Adel D; Al-Tweher, Jozaa N; Al‐Aoh, Hatem A.; Panneerselvam, Chellasamy

doi:10.1002/bio.4204

Cited by 12 publications

(3 citation statements)

References 35 publications

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“…Strong interaction and redox reactions were proposed for the alteration of QDs’ fluorescence properties due to the high positive charge and strong oxidation potentiality. Wang et al and Al-Duais et al also recognized Fe 3+ ions and proposed ground-state complex formation among Fe 3+ and QDs. , …”

Section: Mxene Quantum Dots In Sensing Applicationmentioning

confidence: 99%

Trends in Using Fluorescent MXene Quantum Dots for Selective Detection and Bioimaging Applications: A Review

Singh,

Kumar,

Bera

et al. 2023

ACS Appl. Nano Mater.

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MXene quantum dots (MXene QDs) are considered an excellent emerging zero-dimensional nanomaterial in recent times due to their excellent photophysical and chemical properties. Excitation-dependent emission properties, biocompatibility, photostability, and dispersion stability of these QDs undoubtedly prove to be active potential candidates for environmental and biomedical applications. This review paper focuses on the progress of MXene quantum dots synthesis via various approaches, their sensing toward various analytes, and bioimaging applications from the year 2017 to date. Varied types of approaches have been summarized to prepare high-quality dispersive MXene QDs with a good fluorescence quantum yield. Their formation mechanism via fragmentation and different characterizations has been well represented. The detailed analysis behind fluorescence from QDs has been also discussed. Next, selective recognition of various analytes, including metal ions, proteins, enzymes, drug molecules, and reactive oxygen species via the fluorescence modulation of the quantum dots, has been detailed and documented along with an in-depth mechanism. Their bioimaging application has also been represented. Finally, challenges and perspectives have been enlightened at the end.

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Section: Mxene Quantum Dots In Sensing Applicationmentioning

confidence: 99%

Trends in Using Fluorescent MXene Quantum Dots for Selective Detection and Bioimaging Applications: A Review

Singh,

Kumar,

Bera

et al. 2023

ACS Appl. Nano Mater.

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show abstract

“…These quasi-spherical QDs (~2 nm) exhibited unique photo-physical attributes with higher stability at different physiological conditions. In the presence of Fe 3+ ions, the fluorescence intensity of these QDs was selectively quenched; ensued probes from these QDs illustrated good selectivity and sensitivity towards Fe 3+ ions, providing practical potentials to generate sensitive sensors endowed with biocompatibility features [ 68 ].…”

Section: Biomedical Advancementsmentioning

confidence: 99%

Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications

Iravani

Varma

2022

Nanomaterials

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MXene quantum dots (QDs), with their unique structural, optical, magnetic, and electronic characteristics, are promising contenders for various pharmaceutical and biomedical appliances including biological sensing/imaging, cancer diagnosis/therapy, regenerative medicine, tissue engineering, delivery of drugs/genes, and analytical biochemistry. Although functionalized MXene QDs have demonstrated high biocompatibility, superb optical properties, and stability, several challenging issues pertaining to their long-term toxicity, histopathology, biodistribution, biodegradability, and photoluminescence properties are still awaiting systematic study (especially the move towards the practical and clinical phases from the pre-clinical/lab-scale discoveries). The up-scalable and optimized synthesis methods need to be developed not only for the MXene QD-based nanosystems but also for other smart platforms and hybrid nanocomposites encompassing MXenes with vast clinical and biomedical potentials. Enhancing the functionalization strategies, improvement of synthesis methods, cytotoxicity/biosafety evaluations, enriching the biomedical applications, and exploring additional MXene QDs are crucial aspects for developing the smart MXene QD-based nanosystems with improved features. Herein, recent developments concerning the biomedical applications of MXene QDs are underscored with emphasis on current trends and future prospects.

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“…The method is not only easily operation, but also enhanced the oxidation resistance and highly quantum yield of MQDs. Apart from the above-mentioned molecules, the 2,3-diaminophenazine (DAP), ε-Poly-L-lysine (PLL), polyvinylpyrrolidone (PVP), and bovine serum albumin (BSA) were used to synthesis functionalized MQDs, thereby promoting the MQD in application to biomedical and physical fields [151,[153][154][155]. Furthermore, MQDs possess abundant hydrophilic functional groups.…”

Section: Mqds Modified By Organic Moleculesmentioning

confidence: 99%

Quantum Dots Compete at the Acme of MXene Family for the Optimal Catalysis

2022

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It is well known that two-dimensional (2D) MXene-derived quantum dots (MQDs) inherit the excellent physicochemical properties of the parental MXenes, as a Chinese proverb says, “Indigo blue is extracted from the indigo plant, but is bluer than the plant it comes from.” Therefore, 0D QDs harvest larger surface-to-volume ratio, outstanding optical properties, and vigorous quantum confinement effect. Currently, MQDs trigger enormous research enthusiasm as an emerging star of functional materials applied to physics, chemistry, biology, energy conversion, and storage. Since the surface properties of small-sized MQDs include the type of surface functional groups, the functionalized surface directly determines their performance. As the Nobel Laureate Wolfgang Pauli says, “God made the bulk, but the surface was invented by the devil,” and it is just on the basis of the abundant surface functional groups, there is lots of space to be thereof excavated from MQDs. We are witnessing such excellence and even more promising to be expected. Nowadays, MQDs have been widely applied to catalysis, whereas the related reviews are rarely reported. Herein, we provide a state-of-the-art overview of MQDs in catalysis over the past five years, ranging from the origin and development of MQDs, synthetic routes of MQDs, and functionalized MQDs to advanced characterization techniques. To explore the diversity of catalytic application and perspectives of MQDs, our review will stimulate more efforts toward the synthesis of optimal MQDs and thereof designing high-performance MQDs-based catalysts.

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Bovine serum albumin functionalized blue emitting Ti₃C₂ MXene quantum dots as a sensitive fluorescence probe for Fe³⁺ ion detection and its toxicity analysis

Cited by 12 publications

References 35 publications

Trends in Using Fluorescent MXene Quantum Dots for Selective Detection and Bioimaging Applications: A Review

Trends in Using Fluorescent MXene Quantum Dots for Selective Detection and Bioimaging Applications: A Review

Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications

Quantum Dots Compete at the Acme of MXene Family for the Optimal Catalysis

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