Bovine Ocular Squamous Cell Carcinoma

Tsujita, Hiroki; Plummer, Caryn E.

doi:10.1016/j.cvfa.2010.08.003

Cited by 36 publications

(51 citation statements)

References 47 publications

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“…The cause of ocular SCC is still poorly understood; however, there are several factors including genetic susceptibility, nutrition levels, age, UV light, circumocular apigmentation and viruses that may contribute to its development (Tsujita & Plummer 2010). Besides the eyelids, SCC was observed in the third eyelid in cattle, horses, dogs, cats and a sheep; cornea, in cattle; and bulbar conjunctiva in cattle and one dog.…”

Section: Discussionmentioning

confidence: 99%

Fifty years in the blink of an eye: a retrospective study of ocular and periocular lesions in domestic animals

Martins

Barros

2014

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 34(12):1215-1222, dezembro 2014 1215 RESUMO.-[Cinquenta anos num piscar de olhos: um estudo retrospectivo sobre lesões oculares e perioculares em animais domésticos.] Foi realizada uma investigação para obter-se uma visão geral das lesões oculares e perioculares de mamíferos domésticos diagnosticadas ao longo de um período de 50 anos num laboratório de diagnóstico de patologia veterinária da Região Central do Rio Grande do Sul. Nesse laboratório, durante o período pesquisado foram realizados 33.075 exames histopatológicos, 540 dos quais (1,6%) eram de lesões oculares e perioculares. Por várias razões, 90 espécimes foram excluídos do estudo. As 450 amostras restantes consistiam espécimes de cães (53,5%), bovinos (28,2%), gatos (11,1%), cavalos (5,1%), ovelhas (1,3%), coelhos (0,4%), e porco (0,2% A survey was undertaken aiming to obtain an overview of ocular and periocular lesions diagnosed in domestic mammals over a period of 50 years in a veterinary pathology diagnostic laboratory in the Central Region of the State of Rio Grande do Sul, Brazil. In this lab, 33,075 histophatological exams had been performed over the period surveyed, of which 540 (1.6%) concerned ocular and periocular lesions. For various reasons ninety specimens were excluded from the study and the remaining 450 consisted of samples from dogs (53.5%), cattle (28.2%), cats (11.1%), horses (5.1%) sheep (1.3%), rabbits (0.4%), and pig (0.2%). The eyelids were the most prevalent (248/450) site of lesions in each of the species studied, followed by third eyelid (73/450), and conjunctiva (27/450). In dogs (241 samples) lesions in sebaceous glands (including Meibomian glands) were the most common findings (75/241), followed by melanocytic tumors (52/241) and nonspecific conjunctivitis (13/241). Squamous cell neoplasms, both benign and malignant, were relatively common. In cattle, anatomical sites affected by ocular and periocular lesions, in decreasing order of frequency, were eyelid, cornea and third eyelid. Squamous cell carcinoma (SCC) alone accounted for 80.3% of all diagnoses, while all neoplastic lesions made up for 85.0% of the lesions diagnosed in cattle. Neoplasia accounted for most of the lesions diagnosed in cats (39/50 cases); all of these were malignant, and SCC, hemangiosarcoma and fibrosarcoma were the most common types diagnosed. In horses, 19 out of 23 submissions were neoplasms and most were sarcoid (8/23) and SCC (8/23). There were six submissions from sheep with unpigmented skin, all of which represented SCC of the eyelids (5) and third eyelid (1).

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Section: Discussionmentioning

confidence: 99%

Fifty years in the blink of an eye: a retrospective study of ocular and periocular lesions in domestic animals

Martins

Barros

2014

Pesq. Vet. Bras.

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“…Primary ocular surface squamous cell carcinoma (SCC) is common in cattle and horses but rarely described in the dog with a literature search revealing nine case reports and one retrospective review of 26 cases, all published within the past 27 years. In horses and cattle, lightly pigmented animals and those exposed to higher levels of ultraviolet radiation have an increased risk for developing ocular and adnexal SCC . In dogs, however, these factors have not been demonstrated to influence the development of ocular SCC.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, chronic keratitis, as seen in brachycephalic breeds, and the use of topical cyclosporine have been hypothesized to play a role in the pathogenesis of corneal SCC in dogs . The primary treatment strategy in large animals has consisted of surgical excision of the affected tissue, and recurrence rate may be decreased with the use of adjunctive procedures such as cryotherapy, immunotherapy, radiofrequency hyperthermia, strontium 90 irradiation, or topical chemotherapy . In the dog, surgical excision alone or with adjunctive therapy using cryotherapy, strontium 90 irradiation, or topical chemotherapy has been successful in the treatment of corneal SCC.…”

Section: Introductionmentioning

confidence: 99%

Treatment of corneal squamous cell carcinoma using topical 1% 5‐fluorouracil as monotherapy

Dorbandt

Driskell

Hamor

2015

Veterinary Ophthalmology

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The purpose of this report is to discuss the use of topical 1% 5-fluorouracil as a sole therapy for canine corneal squamous cell carcinoma (SCC). A 12-year-old castrated male pug was evaluated for a well-demarcated, central, 3 mm in diameter, pale pink, raised, right corneal mass. An incisional biopsy was obtained using a #64 beaver blade after topical anesthesia and without sedation. A definitive diagnosis of corneal SCC was obtained after histopathologic evaluation of the biopsy. Topical 1% 5-fluorouracil ointment was applied to the right eye four times daily for 2 weeks followed by no treatment for 2 weeks, then treatment again twice daily for 2 weeks. The cornea remained free of recurrence 10 months after cessation of treatment. In dogs affected with corneal SCC, topical 1% 5-fluorouracil monotherapy may be a viable and cost-effective treatment option with minimal side effects. This chemotherapy agent may also have an effect on corneal pigmentation. Chronic cyclosporine therapy did not contribute to the pathogenesis of corneal SCC in the case described.

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“…Seu desenvolvimento está relacionado à exposição prolongada de raios ultravioleta em pele despigmentada, sem pelos e com lesões prévias. São responsáveis por signiϐicativas perdas econômicas em bovinos em países da América do Norte (Tsujita & Plummer 2010).…”

Section: Introductionunclassified

“…Algumas raças de bovinos como Hereford, Simmental e Holandesa apresentam maior predisposição à ocorrência de CCE (Meuten 2002, Ramos et al 2007, Tsujita & Plummer 2010. Em bovinos e equinos esta neoplasia é observada nas junções mucocutâneas, principalmente na região de pálpebras e genitálias, enquanto em ovinos e caprinos observa-se mais frequentemente na orelha (Meuten 2002, Smith 2006, Scott & Miller 2011.…”

Section: Introductionunclassified

Fatores de risco associados à ocorrência de carcinoma de células escamosas em ruminantes e equinos no semiárido da Paraíba

et al. 2012

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Neste trabalho descreve-se a frequência de carcinomas de células escamosas diagnosticados pelo Laboratório de Patologia Animal (LPA) do Hospital Veterinário da Universidade Federal de Campina Grande (UFCG) em bovinos, ovinos, caprinos e equinos no semiárido da Paraíba, durante o período de 1983 a 2010, analisando dados epidemiológicos e fatores de risco. Foi realizada a análise dos fatores de risco, mediante o teste de qui-quadrado de aderência, considerando como variáveis espécie, raça, sexo, idade e localização da massa tumoral. Durante o período foram registrados 3.153 diagnósticos provenientes de biópsias e necropsias. Destes, 81 casos (2,7%) foram de carcinomas de células escamosas. A frequência por espécie foi de 4% (42/1052) em bovinos, 2,5% (15/603) em equinos, 1,7% (12/709) em ovinos e 1,5% (12/789) em caprinos, sendo significativamente maior em bovinos (p<0,001). Todos os casos apresentavam características histológicas de CCE, variando apenas o grau de diferenciação celular. Em bovinos e caprinos, a frequência do tumor foi significativamente maior em animais adultos (p<0,001 e p<0,005, respectivamente). Nos bovinos a localização preferencial foi em olhos e região periocular (p<0,001) e nos ovinos na pele (p=0,018), principalmente na cabeça, enquanto que nas outras espécies não foram encontradas diferenças significantes na localização do tumor. Sugere-se que a maior frequência de CCE em bovinos deve-se à constituição do rebanho, formado predominantemente por fêmeas da raça Holandesa.

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Bovine Ocular Squamous Cell Carcinoma

Cited by 36 publications

References 47 publications

Fifty years in the blink of an eye: a retrospective study of ocular and periocular lesions in domestic animals

Fifty years in the blink of an eye: a retrospective study of ocular and periocular lesions in domestic animals

Treatment of corneal squamous cell carcinoma using topical 1% 5‐fluorouracil as monotherapy

Fatores de risco associados à ocorrência de carcinoma de células escamosas em ruminantes e equinos no semiárido da Paraíba

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