Bovine Milk Protein-Induced Intestinal Malabsorption of Lactose and Fat in Infants

Malabsorption syndrome with cow's milk intolerance. Clinical findings and course in 54 cases.

“…Our findings concerning the clinical picture of the disease and the initial laboratory findings are fairly consistent with the data presented in many other papers (Fallstr6m, Winberg, and Andersen, 1965;Lamy et al, 1963;Liu et al, 1968). The onset of this disease seems to be limited to early infancy, and thus may lead to severe dehydration and a dangerous situation, sometimes necessitating parenteral nutrition.…”

Immunochemical study of the malabsorption syndrome with cow's milk intolerance

“…Lactose cannot be incriminated, however, as the elimination diet used was breast milk. Earlier clinical studies, in which separate protein fractions of cow's milk were used in provocations (Visakorpi and Immonen, 1967;Liu et al, 1967) suggested that one or more of them are the cause of the malabsorption syndrome. This view is supported by the finding in this study that, within hours of administration, a small dose of cow's milk caused clinical symptoms and a strong local immunological reaction in the intestine.…”

“…A syndrome consisting of failure to thrive, vomiting, diarrhoea, malabsorption, and damage to the jejunal mucosa has been recognized in young infants, many of whom have never received gluten (Davidson, Bumstein, Kugler, and Bauer, 1965;Fallstrom, Winberg, and Andersen, 1965;Kuitunen, 1966;Visakorpi and Immonen, 1967;Liu, Tsao, Moore, and Giday, 1967;Silver and Douglas, 1968). It has been demonstrated earlier that most of these patients are intolerant to cow's milk and especially to its proteins (Davidson et al, 1965;Visakorpi and Immonen, 1967;Liu et al, 1968).…”

Nutritional deprivation during protracted diarrhoea after acute gastroenteritis.

“…The initial lactose intolerance may have been caused by cows' milk protein intolerance (Liu et al, 1968) as we suggested, but we have no formal proof of this. It is experience of the problems of such infants that has been a stimulus to improve the techniques of intravenous feeding.…”