Correspondence 989 10 months) there was an increase in serum alkaline phosphatase values. But the incidence of raised alkaline phosphatase values was not found to increase after the 4th month of therapy.These results are in agreement with the idea that alteration of phosphorus/calcium metabolism during treatment with phenobarbitone depends more on individual sensitivity than on the length of time the drug is given. Phenobarbitone and comparable drugs thus represent 'adverse environmental conditions' capable of making evident the 'genetic defect'.
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