Bovine lactoferrin mRNA: Sequence, analysis, and expression in the mammary gland

Goodman, Richard E.; Schanbacher, F.L.

doi:10.1016/s0006-291x(05)81257-4

Cited by 99 publications

(65 citation statements)

References 27 publications

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“…The increase in mammary cell secretory activity was observed within 24 h of increased suckling intensity, indicating rapid local regulation in response to increased demand of the offspring (Tucker, 1966). Similar experiments have revealed local regulation of lactogenesis and cellular differentiation in ruminants (Akers et al, 1977;Guy et al, 1994), as well as mammary involution and cellular apoptosis (Goodman & Schanbacher, 1991;Quarrie et al, 1994). Taken together, these observations support the concept that mammary cell proliferation and differentiation can be regulated locally by factors within the mammary gland.…”

Section: The Effect Of Milk Removal On Mammary Cell Number and Activitysupporting

confidence: 77%

Regulation of Mammary Development as It Relates to Changes in Milk Production Efficiency

Wall¹,

McFadden²

2012

Milk Production - An Up-to-Date Overview of Animal Nutrition, Management and Health

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Section: The Effect Of Milk Removal On Mammary Cell Number and Activitysupporting

confidence: 77%

Regulation of Mammary Development as It Relates to Changes in Milk Production Efficiency

Wall¹,

McFadden²

2012

Milk Production - An Up-to-Date Overview of Animal Nutrition, Management and Health

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“…To study the mechanism that regulates LF gene expression in epithelial cells faces a challenge, because the LF gene is permanently silenced in a majority of cancer cells [34][35][36]. Due to the lack of a suitable cell system for mechanistic study, most of the regulatory studies on LF were conducted in animals and in transiently transfected culture cell lines [7,17,37,38]. HC-11 is a normal mouse mammary gland cell line which retains the normal phenotype of mammary gland epithelial cells [29].…”

Section: Discussionmentioning

confidence: 99%

Induction of lactoferrin gene expression by innate immune stimuli in mouse mammary epithelial HC-11 cells

Limmon

Imani

et al. 2009

Biochimie

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Lactoferrin (LF) is a multifunctional protein. While its functions and mechanism of actions are actively being investigated, the cellular signals that regulate LF expression have not been as explored. We have previously demonstrated that LF is upregulated by estrogen in reproductive system. In this study, we show that the expression of LF was stimulated by bacterial lipopolysaccharide (LPS) and double-stranded RNA (dsRNA) in normal mouse mammalian HC-11 cells. When cells were exposed to either LPS or dsRNA, the mRNA and protein of LF were increased in a dose-and time-dependent manner, yet the kinetics of LF induction by dsRNA or LPS was different. The LPS and dsRNAinduced LF was mainly released into the culture medium where it blocked TNF-α production in exposed cells. We explored the mechanisms of LF induction by LPS and dsRNA using specific inhibitors and found that the induction could be attenuated by inhibitors to PKC, NF-kB, p38 and JNK, but not by an inhibitor to PKA. Interestingly, ERK inhibitor was effective against dsRNA but not against LPS induction of LF. These data suggest that LF was induced by LPS and dsRNA through PKC, NF-kB and MAPK pathways which in turn plays an inhibitory role in the continuation of innate inflammation.

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“…The response to induced involution in ruminant mammary tissue is slower than that in rodents. For example, mRNA abundance of a-, b-and g-casein was observed to fall by up to 95% in rat mammary tissue within 24 h of litter removal (Travers et al, 1996), whereas the abundance of casein and a-lactalbumin mRNA was reduced in bovine mammary tissue 3 days after cessation of milk removal (Goodman and Schanbacher, 1991). Hence, after 7 days, a S1 -casein and a-lactalbumin mRNA were decreased by 85% and 99%, respectively (Wilde et al, 1997).…”

Section: Altered Dry Periodsmentioning

confidence: 97%

Effects of continuous lactation and short dry periods on mammary function and animal health

Collier

Annen-Dawson

Pezeshki

2012

Animal

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The dry period is required to facilitate cell turnover in the bovine mammary gland in order to optimize milk yield in the next lactation. Traditionally, an 8-week dry period has been a standard management practice for dairy cows based on retrospective analyses of milk yields following various dry period lengths. However, as milk production per cow has increased, transitioning cows from the nonlactating state to peak milk yield has grown more problematic. This has prompted new studies on dry period requirements for dairy cows. These studies indicate a clear parity effect on dry period requirement. First parity animals require a 60-day dry period, whereas lactations following later parities demonstrate no negative impact with 30-day dry period or even eliminating the dry period when somatotropin (ST) is also used to maintain milk yields. Shortened dry periods in first parity animals were associated with reduced mammary cell turnover during the dry period and early lactation and increased numbers of senescent cells and reduced functionality of lactating alveolar mammary cells postpartum. Use of ST and increased milking frequency postpartum reduced the impact of shortened dry periods. The majority of new intramammary infections occur during the dry period and persist into the following lactation. There is therefore the possibility of altering mastitis incidence by modifying or eliminating the dry period in older parity animals. As the composition of mammary secretions including immunoglobulins may be reduced when the dry period is reduced or eliminated, there is the possibility that the immune status of cows during the peripartum period is influenced by the length of the dry period.

show abstract

Bovine lactoferrin mRNA: Sequence, analysis, and expression in the mammary gland

Cited by 99 publications

References 27 publications

Regulation of Mammary Development as It Relates to Changes in Milk Production Efficiency

Regulation of Mammary Development as It Relates to Changes in Milk Production Efficiency

Induction of lactoferrin gene expression by innate immune stimuli in mouse mammary epithelial HC-11 cells

Effects of continuous lactation and short dry periods on mammary function and animal health

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