Bovine Herpesviruses

Ludwig, Hanns

doi:10.1007/978-1-4684-7012-3_4

Cited by 95 publications

(109 citation statements)

References 162 publications

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“…This technique has served as a valuable tool for separation and classification of numerous species, types and strains of herpesviruses, as previously reported for bovid Ludwig, 1983), equid (Studdert eta!., 1981 and human herpesviruses (Preston et al, 1978;Buchman et al, 1978).…”

Section: Discussionmentioning

confidence: 83%

“…The intermediate gels (i) contained 20 lal/cm 2 of foetal calf serum (A) or BHV-6-specific goat antibodies (B). Uninfected 6ell lysates gave no precipitation arcs with the same sera (Ludwig, 1983). Coomassie Brilliant Blue staining.…”

Section: Properties Of the Bhv-6 Dnamentioning

confidence: 86%

“…DNA analysis has shown fundamental differences between BHV-1 and the goat virus. In accordance with a proposed classification of bovine (bovid) herpesviruses (Ludwig, 1983), and based on the recommendations of the Committee for Taxonomy of Viruses , the goat herpesvirus is designated as bovid herpesvirus 6 (BHV-6). …”

Section: Introductionmentioning

confidence: 99%

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Goat Herpesviruses: Biological and Physicochemical Properties

Engels

Gelderblom

Darai

et al. 1983

Journal of General Virology

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Section: Discussionmentioning

confidence: 83%

Section: Properties Of the Bhv-6 Dnamentioning

confidence: 86%

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Goat Herpesviruses: Biological and Physicochemical Properties

Engels

Gelderblom

Darai

et al. 1983

Journal of General Virology

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“…Some of these antibodies react type specifically, whereas others recognize epitopes common to both HSV type 1 (HSV-1) and HSV-2 (Zweig et al, 1979;Pereira et al, 1980;Balachandran et al, 1981;Showalter et al, 1981;McLean.et al, 1982;Marlin et al, 1985). During the course of our studies on the immunological relationship between members of the Simplexviruses (Norrild et al, 1978;Ludwig, 1983), a subfamily of the Alphaherpesvirinae (Brown, 1986), we recently demonstrated that bovine herpes mammillitis virus (BHV-2)-specific monoclonal antibodies neutralize BHV-2, HSV-1 and HSV-2 by reacting with epitopes of the glycoprotein B. These antibodies detected epitopes located in the nuclei of infected cells (unpublished observations).…”

Section: Introductionmentioning

confidence: 86%

Monoclonal Antibodies Against Herpes Simplex Virus Type 1-infected Nuclei Defining and Localizing the ICP8 Protein, 65K DNA-binding Protein and Polypeptides of the ICP35 Family

Schenck

Pietschmann

Gelderblom

et al. 1988

Journal of General Virology

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SUMMARYThe production and properties of monoclonal antibodies raised against herpes simplex virus type 1 (HSV-1)-infected cell nuclei are described. Biological and immunochemical assays revealed that these antibodies recognize four different proteins in HSV-1-infected cells. Four antibodies reacted with the major DNA-binding protein (ICP8) and six with the 65K DNA-binding protein. Two antibodies detected the ICP35 family of proteins and one antibody bound to a protein with an apparent mol. wt. of 60K. Immune electron microscopy showed that the major DNA-binding protein had a patchy distribution, whereas the 65K DNA-binding protein was evenly spread in the infected cell nuclei. The 60K protein as well as the polypeptides of the ICP35 family were preferentially found associated with the viral capsid.

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“…BHV-4 is a ubiquitous virus in cattle (Ludwig, 1983;Thiry et al, 1989). BHV-4 was originally referred to as bovine CMV primarily because its biological properties and growth characteristics in tissue culture closely resemble those of CMV (Storz et al, 1984;Staczek, 1990).…”

mentioning

confidence: 99%

Experimental Infection with Bovine Herpesvirus-4 Enhances Atherosclerotic Process in Rabbits

Lin

Jiang

Eng

et al. 2000

Laboratory Investigation

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SUMMARY:An association of herpesvirus and atherosclerosis has been suggested by seroepidemiologic studies and detection of the virus in arterial tissues. To facilitate the studies of the pathogenic role of herpesvirus in atherosclerosis, we established a rabbit model of atherosclerosis with bovine herpesvirus type-4 (BHV-4). Forty New Zealand White rabbits were randomly divided into six groups. Groups 1, 2, and 3 were inoculated iv with BHV-4 and control Groups 4, 5, and 6 with normal saline. Groups 1 and 4 were fed a regular diet throughout the experiment; Groups 2 and 5 were fed a diet supplemented with 2% cholesterol for 3 weeks starting at 3 weeks postinoculation; and Groups 3 and 6 with a diet supplemented with 2% cholesterol for 6 weeks starting at 3 days postinoculation. Extensive atherosclerotic lesions in Groups 2, 3, and 6, and small lesions in two rabbits in Group 1 were observed, but no obvious lesions were observed in Groups 4 and 5. BHV-4 DNA was demonstrated by polymerase chain reaction and liquid hybridization in aortic sections, various tissue samples, and peripheral blood mononuclear cells of all infected rabbits. Our studies demonstrated that BHV-4 can accelerate the atherosclerotic process in rabbits, and that experimental infection of rabbits with BHV-4 can be a useful atherosclerosis model. (Lab Invest 2000, 80:3-11).

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Bovine Herpesviruses

Cited by 95 publications

References 162 publications

Goat Herpesviruses: Biological and Physicochemical Properties

Goat Herpesviruses: Biological and Physicochemical Properties

Monoclonal Antibodies Against Herpes Simplex Virus Type 1-infected Nuclei Defining and Localizing the ICP8 Protein, 65K DNA-binding Protein and Polypeptides of the ICP35 Family

Experimental Infection with Bovine Herpesvirus-4 Enhances Atherosclerotic Process in Rabbits

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