Bovine Casein Hydrolysate (C12 Peptide) Reduces Blood Pressure in Prehypertensive Subjects

Cadée, Jenny A.; Chang, Chou-Yue; Chen, Chien‐Wei; Huang, Chien‐Ning; Chen, Su-Lin; Wang, Chin‐Kun

doi:10.1016/j.amjhyper.2006.06.005

Cited by 73 publications

(50 citation statements)

References 27 publications

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“…Moreover, Sekyia et al (38) and Sugai (39) did not use control groups. Double-blinding was reported only by Cadée et al (42) and Townsend et al (41) . Taken together, the five trials appear to have a high risk of bias, which weakens the strength of evidence supporting their conclusions.…”

Section: Impact Of Milk Consumption On Cardiovascular Healthmentioning

confidence: 99%

“…Townsend et al (41) performed an acute, randomised, single-blind, cross-over pilot study in ten hypertensive participants who were assigned randomly to one of the five treatment regimens (100 mg C12; 200 mg C12; 50 mg C12 þ 877 mg alginic acid; 100 mg C12 þ 1754 mg alginic acid; placebo). Significant reductions in BP were only seen in the group consuming the high dose of C12 (100 mg) combined with alginic acid (1754 mg): 2 9·2 mmHg in SBP 6 h after oral administration compared with 2 h after (42) 48 , ingestion (P¼0·02), and 26·0 mmHg in DBP 6 h after oral administration compared with 2 h (P¼0·015). Cadée et al (42) studied the effects of a daily intake of 3·8 g C12 peptide in forty-eight Taiwanese subjects.…”

Section: Impact Of Milk Consumption On Cardiovascular Healthmentioning

confidence: 99%

“…Significant reductions in BP were only seen in the group consuming the high dose of C12 (100 mg) combined with alginic acid (1754 mg): 2 9·2 mmHg in SBP 6 h after oral administration compared with 2 h after (42) 48 , ingestion (P¼0·02), and 26·0 mmHg in DBP 6 h after oral administration compared with 2 h (P¼0·015). Cadée et al (42) studied the effects of a daily intake of 3·8 g C12 peptide in forty-eight Taiwanese subjects. After 4 weeks, SBP and DBP were reduced by 10·7 mmHg (P, 0·05) and 6·9 mmHg (P, 0·05), respectively, compared with baseline.…”

Section: Impact Of Milk Consumption On Cardiovascular Healthmentioning

confidence: 99%

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The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

2013

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CVD are the leading cause of death worldwide. Hypertension, a major controllable risk factor of CVD, is intimately associated with vascular dysfunction, a defect which is also now recognised to be a major, modifiable risk factor for the development of CVD. The purpose of the present review was to critically evaluate the evidence for the effects of milk proteins and their associated peptides on blood pressure (BP) and vascular dysfunction. After a detailed literature search, the number of human trials evaluating the antihypertensive effects of caseinderived peptides (excluding isoleucine-proline-proline and valine-proline-proline) was found to be limited; the studies were preliminary with substantial methodological limitations. Likewise, the data from human trials that examined the effects of whey protein and peptides were also scarce and inconsistent. To date, only one study has conducted a comparative investigation on the relative effects of the two main intact milk proteins on BP and vascular function. While both milk proteins were shown to reduce BP, only whey protein improved measures of arterial stiffness. In contrast, a growing number of human trials have produced evidence to support beneficial effects of both milk proteins and peptides on vascular health. However, comparison of the relative outcomes from these trials is difficult owing to variation in the forms of assessment and measures of vascular function. In conclusion, there is an accumulating body of evidence to support positive effects of milk proteins in improving and/or maintaining cardiovascular health. However, the variable quality of the studies that produced this evidence, and the lack of robust, randomised controlled intervention trials, undermines the formulation of firm conclusions on the potential benefits of milk proteins and peptides on vascular health.

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Section: Impact Of Milk Consumption On Cardiovascular Healthmentioning

confidence: 99%

Section: Impact Of Milk Consumption On Cardiovascular Healthmentioning

confidence: 99%

Section: Impact Of Milk Consumption On Cardiovascular Healthmentioning

confidence: 99%

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The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

2013

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“…Among these peptides, the two lactotripeptides VPP and IPP have been the subject of various in vivo studies using fermented-milk products [13]. Additionally, a potent ACE-inhibiting effect was obtained in both hypertensive and prehypertensive humans in a double-blind, placebo-controlled trial with a bovine casein hydrolysate [17,127]. The effect was attributed to a longer peptide representing the sequence f23-34 of α s1 -casein [25], but it remains questionable whether such peptides can be absorbed in an intact form.…”

Section: Orally Active Ace-inhibitory Peptidesmentioning

confidence: 99%

ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties

Sieber

Bütikofer

Egger

et al. 2009

Dairy Sci. Technol.

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-During the ripening of cheese, a large number of peptides are formed from casein. Some of these peptides have been shown to exert an antihypertensive effect due to their angiotensin-I-converting enzyme (ACE)-inhibitory activity. Recently, several studies have investigated the ACE-inhibiting potential of cheese, and various ACE-inhibiting peptides have been isolated and identified from different cheese varieties. The present review focuses on the occurrence of two tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in cheese. These tripeptides were first described in fermented-milk products and have been demonstrated to exert a blood pressure-lowering effect in humans with mild hypertension. The influence of cheesemaking and ripening on the release of ACE-inhibiting peptides is revealed. Finally, the antihypertensive potential of cheese with high ACE-inhibitory activity is discussed with regard to the bioavailability of the peptides involved.

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“…For example, Ballard et al (16) used 5 g of a whey protein hydrolysate per d to observe a vascular endothelial response. In addition, Cadee et al (17) used 3·8 g of a bovine casein hydrolysate per d and observed a decrease of respectively -10·7 and -6·9 mmHg in SBP and DBP compared with the baseline after a 4-week intervention period. In fact, the Food and Drug Administration has approved a claim for this protein hydrolysate, which has been called C12 Peption® and for which the targeted daily intake has been set at 4·2 g/d.…”

Section: Discussionmentioning

confidence: 99%

Effects of NWT-03, an egg-protein hydrolysate, on blood pressure in normotensive, high-normotensive and mild-hypertensive men and women: a dose-finding study

Severins

Morrison²,

Mensink

2017

Br J Nutr

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Angiotensin-converting enzyme (ACE) inhibitors are important agents in blood pressure (BP) management. It was recently shown that the egg-protein hydrolysate NWT-03 inhibited ACE in Zucker diabetic fatty rats. We therefore designed a dose-finding study to assess the effects of 1, 2 and 5 g NWT-03 on daytime, 36-h, and night-time systolic and diastolic BP (SBP and DBP) in ninety-two generally healthy subjects with normal BP (n 29), high-normal BP (n 34) or mild hypertension (n 29). The study had a cross-over design with six treatment arms (1 g NWT-03 or placebo in period 1 and placebo or 1 g NWT-03 in period 2, 2 g NTW-03 or placebo in period 1 and placebo or 2 g NWT-03 in period 2, or 5 g NTW-03 or placebo in period 1 and placebo or 5 g NTW-03 in period 2). A comparable number of subjects from each BP class were included in each study arm. Duration of both treatments in each arm was 7 d, separated by 5-d wash-out periods. BP was measured with an ambulatory BP monitor before and after the treatments. In mild-hypertensive subjects, 2 g NWT-03 significantly decreased daytime SBP (7·9 mmHg; P = 0·006), daytime DBP (4·2 mmHg; P = 0·009), 36-h SBP (6·9 mmHg; P = 0·015) and 36-h DBP (3·5 mmHg; P = 0·035) compared with placebo subjects. In addition, in mild-hypertensive subjects, 5 g NWT-03 significantly decreased night-time SBP (14·8 mmHg; P = 0·008) and night-time DBP (8·4 mmHg; P = 0·020) compared with that in placebo subjects. To conclude, we found that 2 g NWT-03 lowered daytime and 36-h BP in subjects with mild hypertension, and 5 g NWT-03 lowered night-time BP in subjects with mild hypertension. As no doseresponse relationship was evident, these results should be interpreted with care, and additional studies are needed.

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Bovine Casein Hydrolysate (C12 Peptide) Reduces Blood Pressure in Prehypertensive Subjects

Abstract: This study shows that C12 Peptide reduces BP in prehypertensive people.

Cited by 73 publications

References 27 publications

The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties

Effects of NWT-03, an egg-protein hydrolysate, on blood pressure in normotensive, high-normotensive and mild-hypertensive men and women: a dose-finding study

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