Bovine babesiosis and anaplasmosis: Control by premunition and chemoprophylaxis

Todorovic, R. A.; Lopez, L.A.; López, Albert García; Gonzalez, E.F.

doi:10.1016/0014-4894(75)90056-9

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…Our study determined that parasitaemia existed in rabbits for 28 days and increased to 2–4% on the fourth day post-inoculation. Similar findings were reported based on a premonition naturally developed in young animals when exposed to B. bigemina [ 39 ].…”

Section: Discussionsupporting

confidence: 89%

Propagation of Babesia bigemina in Rabbit Model and Evaluation of Its Attenuation in Cross-Bred Calves

Ullah

Ashraf

Rehman

et al. 2022

Animals

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Bovine babesiosis (BB) is a vector-borne disease (VBD) that affects cattle in tropical and subtropical areas, caused by the haemoprotozoa Babesia bovis and Babesia bigemina. It is transmitted by tick bites belonging to the genus Rhipicephalus and is clinically characterized by high fever, depression, anorexia, decreased milk and meat production, haemoglobinemia, haemoglobinuria, jaundice, and pregnancy loss. In this study, the propagation of B. bigemina was evaluated by intraperitoneally inoculating 3 × 106 red blood cells infected with B. bigemina into rabbits. The study showed that variations in rabbit body temperatures are related to induced bovine babesiosis. A significant increase in temperature (39.20 ± 0.23 °C) was observed from day 4 onwards, with the maximum temperature (40.80 ± 1.01 °C) on day 9 post-inoculation. This study included susceptible cross-bred calves for in vivo attenuation, and they were compared with an infected group. The calves in the infected group showed a significant increase in temperature (38.79 ± 0.03 °C) from day 3 onwards and a maximum temperature (41.3 ± 0.17 °C) on day 11. Inoculated calves showed a gradual rise in temperature post-inoculation, but the difference was not significant. Inoculated calves did not show parasitaemia, whereas 32% of infected calves displayed parasitaemia. As compared to inoculated calves post-inoculation, packed cell volume (PCV) decreased (16.36 ± 1.30) for infected calves. However, there were statistically significant differences (p ≤ 0.05) in temperatures, parasitaemia, and PCV in both inoculated and infected calves. The current study aimed to attenuate B. bigemina in rabbit models and evaluate the pathogenic potential of this organism in naive calves. In conclusion, B. bigemina proliferation was attenuated in rabbits. The rabbit model can be used to study B. bigemina in vivo in order to reduce its pathogenicity.

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Section: Discussionsupporting

confidence: 89%

Propagation of Babesia bigemina in Rabbit Model and Evaluation of Its Attenuation in Cross-Bred Calves

Ullah

Ashraf

Rehman

et al. 2022

Animals

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“…Thousands of doses of these vaccines are distributed every day, enabling more affordable cattle production. However, a few reports identified A. centrale as the cause of outbreaks with fatalities ( 48 ) or failure to induce immunity against A. marginale challenge ( 49 , 50 ). Potgieter ( 42 ), citing Theiler, stated that immunization with A. centrale attenuates the clinical presentation of A. marginale infection but does not prevent the infection from occurring.…”

Section: Types Of Vaccinesmentioning

confidence: 99%

Bovine Anaplasmosis: Will there ever be an almighty effective vaccine?

et al. 2022

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Bovine anaplasmosis is a tick-borne bacterial disease with a worldwide distribution and the cause of severe economic losses in the livestock industry in many countries, including México. In the present work, we first review the elements of the immune response of the bovine, which allows ameliorating the clinical signs while eliminating the majority of the blood forms and generating an immunologic memory such that future confrontations with the pathogen will not end in disease. On the other hand, many vaccine candidates have been evaluated for the control of bovine anaplasmosis yet without no commercial worldwide effective vaccine. Lastly, the diversity of the pathogen and how this diversity has impaired the many efforts to control the disease are reviewed.

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“…Cell-mediated immunity in combination with antibodies of various activities seem to be the main protective mechanism in blood protistan diseases (Ristic, 1976 weight more than the control cattle. Todorovic et al (1975) have recommended that post-inoculation reactions due to Bab~ia spp. and Anaplasma marginale be controlled with one i.m.…”

Section: Immunity To Blood Protistan Diseasesmentioning

confidence: 99%

Chemo-immunization of ruminants againstBabesia, Anaplasma, Theileria andCowdria species

Aliu

1980

Vet Res Commun

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Bovine babesiosis and anaplasmosis: Control by premunition and chemoprophylaxis

Cited by 13 publications

References 13 publications

Propagation of Babesia bigemina in Rabbit Model and Evaluation of Its Attenuation in Cross-Bred Calves

Propagation of Babesia bigemina in Rabbit Model and Evaluation of Its Attenuation in Cross-Bred Calves

Bovine Anaplasmosis: Will there ever be an almighty effective vaccine?

Chemo-immunization of ruminants againstBabesia, Anaplasma, Theileria andCowdria species

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