Bound Antibodies of Skin Homografts

Immune cytopenias and some associated problems of immunohematology

“…Complement-dependent cytotoxic antibodies reacting with allogeneic and autologous polymorphonuclear leukocytes are strongly expressed in such patients, particularly in children. Our studies showed that in contrast to aUoimmune neutropenias of newborns, the sera of patients with autoimmune neutropenias react with the leukocytes of the mother, father, and nonrelatives [14,41]. A high inverse correlation was noted between the titer of granulocytotoxic antibodies and the absolute count of polymorphonuclear leukocytes in the patient's blood.…”

“…A specific feature of these antibodies is that their target cells are the red cells of patients with erythremia during exacerbation [ 15,41 ]. During remission the erythrocytes of patients with erythremia lose the capacity of reacting with the serum of AA patients and regain this capacity during a relapse.…”

“…A typical example is autoimmune hemolytic anemia (AIHA). The principal feature in the pathogenesis of this disease is increased destruction of erythrocytes because of the production of antierythrocytic antibodies followed by destruction of the formed elements of the blood loaded with autoantibodies in the blood vessels [23] or, as in vitro experiments demonstrated, in the spleen, evidently during passage of the blood through the malpighian bodies at the expense of B lymphocytes possessing, according to our data, receptors to the Fc-fragment of immunoglobulins [3,201. Not only antierythrocytic, but antilymphocytic antibodies as well, were found in AIHA patients [6,17,31,41 ]. Autolymphocytotoxins were cold-specific and could be detected at 18-22~ Lymphocytotoxic antibodies reacted mostly with the T population of lymphocytes.…”

Genetic differences by platelet-specific antigens used for monitoring allomyelotransplant engraftment

“…The informative value of the markers could be two-directional or unidirectional (Table 1). [1][2][3][4][5][6][7][8]. The siblings differed by allele genes of several locuses or genes of the entire HPA locus and were homo-or heterozygotic by differing alleles.…”

“…If it is impossible to evaluate chimerism directly at a molecular or biochemical level, the differences can be detected at the level of final products, for example, terminal sugars (blood groups) [7,8,10,25]. Erythrocyte phenotyping is a simple, rapid, and highly sensitive procedure (0.04-3.00%) [15].…”