Genetic differences by platelet-specific antigens used for monitoring allomyelotransplant engraftment

Abstract

Monitoring of allomyelotransplant engraftment is essential for evaluation of the function of transplanted cells and timely diagnosis of disease relapse. The possibility of using differences by HPA genes for monitoring of survival of transplanted hemopoietic stem cells was studied. Differences by HPA genes in HLA-identical sibs can be used for the analysis of chimerism after myelotransplantation.

Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry for genotyping of human platelet‐specific antigens

“…In transfusion medicine, mismatches between donor and recipient for HPAs can cause refractoriness to PLT transfusions and posttransfusion purpura 7 . Matching of HPAs can improve the success of PLT transfusion and stem cell transplantation 8‐10 …”