Botulinum toxin type A for facial wrinkles

Camargo, Cristina Pires; Xia, Jun; Costa, Caroline Sousa; Gemperli, Rolf; Tatini, Maria D.C.; Bulsara, Max; Riera, Rachel

doi:10.1002/14651858.cd011301.pub2

Cited by 21 publications

(29 citation statements)

References 104 publications

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“…If the desired outcomes are not attained, an additional retouching treatment may follow. Likewise, during an injection procedure, manual blocking of the inner boundary of the orbital rim should be carried out [ 39 ]. The injection should be performed gently and slowly to prevent BoNT from laterally diffusing to the eyelids [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Novel Anatomical Guidelines on Botulinum Neurotoxin Injection for Wrinkles in the Nose Region

Lee

et al. 2022

Toxins

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Botulinum neurotoxin injection surrounding the nose area is frequently used in aesthetic settings. However, there is a shortage of thorough anatomical understanding that makes it difficult to treat wrinkles in the nose area. In this study, the anatomical aspects concerning the injection of botulinum neurotoxin into the nasalis, procerus, and levator labii superioris alaeque muscles are assessed. In addition, the present knowledge on localizing the botulinum neurotoxin injection point from a newer anatomy study is assessed. It was observed that, for the line-associated muscles in the nose region, the injection point may be more precisely defined. The optimal injection sites are the nasalis, procerus, and levator labii superioris alaeque muscles, and the injection technique is advised. We advise the best possible injection sites in association with anatomical standards for commonly injected muscles to increase efficiency in the nose region by removing the wrinkles. Similarly, these suggestions support a more precise procedure.

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Section: Discussionmentioning

confidence: 99%

Novel Anatomical Guidelines on Botulinum Neurotoxin Injection for Wrinkles in the Nose Region

Lee

et al. 2022

Toxins

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“…Its duration of effect is considered to last 4-6 months, however, authors of a recent Cochrane review note that defining its duration of effect needs further study. 43 Benefits of using topical HA in conjunction with BoNTA injection are also present in the literature. An open-label, before-and-after, interventional study highlighted the possible benefits post-BoNTA of a topical HA, which led to significant improvement in facial fine lines and wrinkles after 8 weeks of treatment when compared to baseline.…”

Section: Lasers For Skin Rejuvenationmentioning

confidence: 99%

“…42 Use of topical HA in combination with BoNTA BoNTA is frequently used in clinical practice for relaxing facial muscles of the upper face, which in turn gives the perception that there are fewer wrinkles. 43 BoNTA is injected into muscle, binding at the nerve terminal, which prevents release of the neurotransmitter, acetylcholine, from the nerve synapse. Thus, muscle contraction (and hyperdynamic wrinkle) is prevented.…”

Section: Lasers For Skin Rejuvenationmentioning

confidence: 99%

Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

Bravo¹,

Correia²,

Gonçalves³

et al. 2022

Dermatologic Therapy

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Skin aging goes beyond a chronological process and also results from extrinsic factors referred to as the exposome. Hyaluronic acid (HA) is an important component of the extracellular matrix, with loss starting at 25 years old. While many studies of HA concern topical use, few literature reviews only address the use of topical HA in dermatology. This review describes the different characteristics of HA-containing cosmeceuticals, with a focus on skin aging and the impact of exposome factors on HA synthesis and degradation. A review was performed using the terms HA, hyaluronan, topical, dermatology, cosmetic, aging treatment, exposome, and cosmeceuticals.Results are also presented from a recent randomized controlled trial (RCT), which investigated the additional benefit of using a HA epidermic filler (HA-filler serum) combined with Botulinum toxin type A (BoNTA) to treat signs of skin aging. Subjects were randomized to two groups: HA-filler serum starting 24 h after the BoNTA injection then twice daily for 24 weeks, or the control group, which received BoNTA. HA is a key ingredient used in cosmeceuticals for its hydration/antiaging properties (hygroscopic, rheological, and viscoelastic). Several clinical studies indicate that HA is both well tolerated and effective, adjuvant to both post-surgical and facial rejuvenation procedures. In the RCT, one of few studies to combine BoNTA and HA with a 6-month follow-up, the HA-filler serum lengthened the duration of BoNTA's effect in reducing wrinkles. Numerous studies support HA-based cosmeceuticals as a noninvasive, effective solution for improving skin hydration and rejuvenation.

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“…The first large meta-analysis of individual patient data from global clinical OnaBoNTA registration studies originates from 2009 (16). Just recently a large Cochrane data base review was performed re-emphasizing the good safety profile of BoNTA, yet stating that there is a lack of evidence about the effects of multiple cycles of BoNTA, frequency of major AEs, duration of effect and efficacy especially for recently-approved BoNTA (17).…”

Section: Long-term Safetymentioning

confidence: 99%

“…17 Just recently, a large Cochrane database review was performed reemphasizing the good safety profile of BoNTA, yet stating that there is a lack of evidence about the effects of multiple cycles of BoNTA, frequency of major adverse events (AEs), duration of effect, and efficacy especially for recently approved BoNTA. 18…”

Section: Long-term Safetymentioning

confidence: 99%

Botulinum Toxins for Esthetic Facial Injections: A Scientific Review to Support Evidence-Based Best Practice

Philipp‐Dormston

Bertossi

Houschyar³

et al. 2022

Facial Plast Surg

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Botulinum Toxins (BoNT) are complex biological products. Each licensed BoNTA has its own individual characteristics resulting into different attributes, some of them being of clinical relevance. Besides profound anatomical knowledge and understanding of aesthetic principles, the responsible injecting physician should be aware of those pharmaceutical and clinical properties. Especially against the background of new BoNTA formulations receiving approval by the authorities a critical and dedicated discussion on the individual characteristics should take place and the potential relevance on the treatment outcome should be taken into consideration.

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Botulinum toxin type A for facial wrinkles

Abstract: Analysis 69.2. Comparison 69: Liquid AbobotulinumtoxinA 20 units versus Liquid AbobotulinumtoxinA 75 units one cycle of treatment, glabellar lines, Outcome 2: Any major adverse events (eyelid ptosis, eyelid sensory disorder, strabismus

Cited by 21 publications

References 104 publications

Novel Anatomical Guidelines on Botulinum Neurotoxin Injection for Wrinkles in the Nose Region

Novel Anatomical Guidelines on Botulinum Neurotoxin Injection for Wrinkles in the Nose Region

Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

Botulinum Toxins for Esthetic Facial Injections: A Scientific Review to Support Evidence-Based Best Practice

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