Botulinum Toxin Type A: Assessing The Effects on The Brain Stem

Seymen, Cemile Merve; Tuncer, Serhan; Ayhan, Sühan; Elmas, Çiğdem

doi:10.1007/s00266-018-1092-3

Aesth Plast Surg

2018

DOI: 10.1007/s00266-018-1092-3

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Botulinum Toxin Type A: Assessing The Effects on The Brain Stem

Cemile Merve Seymen

Serhan Tuncer

Sühan Ayhan

et al.

Abstract: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

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Cited by 3 publications

References 23 publications

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A Transdermal Prion‐Bionics Supermolecule as a RAB3A Antagonist for Enhancing Facial Youthfulness

Liu,

Ding,

Yang

et al. 2024

Advanced Science

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The mechanism research of skin wrinkles, conducted on volunteers underwent high‐intensity desk work and mice subjected to partial sleep deprivation, revealed a significant reduction in dermal thickness associated with the presence of wrinkles. This can be attributed to the activation of facial nerves in a state of hysteria due to an abnormally elevated interaction between SNAP25 and RAB3A proteins involved in the synaptic vesicle cycle (SVC). Facilitated by AI‐assisted structural design, a refined peptide called RSIpep is developed to modulate this interaction and normalize SVC. Drawing inspiration from prions, which possess the ability to protect themselves against proteolysis and invade neighboring nerve cells through macropinocytosis, RSIpep is engineered to demonstrate a GSH‐responsive reversible self‐assembly into a prion‐like supermolecule (RSIprion). RSIprion showcases protease resistance, micropinocytosis‐dependent cellular internalization, and low adhesion with constituent molecules in the cuticle, thereby endowing it with the transdermic absorption and subsequent biofunction in redressing the frenzied SVC. As a facial mud mask, it effectively reduces periorbital and perinasal wrinkles in the human face. Collectively, RSIprion not only presents a clinical potential as an anti‐wrinkle prion‐like supermolecule, but also exemplifies a reproducible instance of bionic strategy‐guided drug development that bestows transdermal ability upon the pharmaceutical molecule.

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A Transdermal Prion‐Bionics Supermolecule as a RAB3A Antagonist for Enhancing Facial Youthfulness

Liu,

Ding,

Yang

et al. 2024

Advanced Science

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show abstract

Effects of zinc supplementation on duration and action of botulinum toxin applied to face muscles: A systematic review of randomized clinical trials

Trindade

Melo

Mendes

et al. 2023

Journal of Trace Elements and Minerals

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A sensitive thrombin-linked sandwich immunoassay for protein targets using high affinity phosphorodithioate modified aptamer for thrombin labeling

Wang

Sun

Zhao

2020

Talanta

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Botulinum Toxin Type A: Assessing The Effects on The Brain Stem

Abstract: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Cited by 3 publications

References 23 publications

A Transdermal Prion‐Bionics Supermolecule as a RAB3A Antagonist for Enhancing Facial Youthfulness

A Transdermal Prion‐Bionics Supermolecule as a RAB3A Antagonist for Enhancing Facial Youthfulness

Effects of zinc supplementation on duration and action of botulinum toxin applied to face muscles: A systematic review of randomized clinical trials

A sensitive thrombin-linked sandwich immunoassay for protein targets using high affinity phosphorodithioate modified aptamer for thrombin labeling

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