Botulinum toxin injections for low-back pain and sciatica

Piriformis syndrome: implications of anatomical variations, diagnostic techniques, and treatment options

“…Although adequate relief from low back pain is not always possible, emerging evidence suggests that botulinum neurotoxin injections may play a role in effectively treating pain disorders related to piriformis syndrome [25]. The mechanism behind the use of botulinum neurotoxin injections involves the blockage of nerve impulses, effectively rendering muscles unable to contract and leaving them in a state of relaxation, paralysis or both [25].…”

“…The mechanism behind the use of botulinum neurotoxin injections involves the blockage of nerve impulses, effectively rendering muscles unable to contract and leaving them in a state of relaxation, paralysis or both [25]. Injections of botulinum neurotoxin may take up to 2-4 days to take effect and the effects can last from 3 to 6 months before these injections can be repeated [25].…”

“…The mechanism behind the use of botulinum neurotoxin injections involves the blockage of nerve impulses, effectively rendering muscles unable to contract and leaving them in a state of relaxation, paralysis or both [25]. Injections of botulinum neurotoxin may take up to 2-4 days to take effect and the effects can last from 3 to 6 months before these injections can be repeated [25]. A review conducted by Waseem et al [25] to determine the effects of botulinum toxin injections on pain, function, disability (including return-to-work) and patient satisfaction in adults with lower back pain included three randomized trials consisting of a total of 123 patients.…”

“…Injections of botulinum neurotoxin may take up to 2-4 days to take effect and the effects can last from 3 to 6 months before these injections can be repeated [25]. A review conducted by Waseem et al [25] to determine the effects of botulinum toxin injections on pain, function, disability (including return-to-work) and patient satisfaction in adults with lower back pain included three randomized trials consisting of a total of 123 patients. The first study demonstrated that botulinum neurotoxin injections were more effective in reducing pain at 3 and 8 weeks and improving function at 8 weeks as compared to saline injections [25].…”

“…A review conducted by Waseem et al [25] to determine the effects of botulinum toxin injections on pain, function, disability (including return-to-work) and patient satisfaction in adults with lower back pain included three randomized trials consisting of a total of 123 patients. The first study demonstrated that botulinum neurotoxin injections were more effective in reducing pain at 3 and 8 weeks and improving function at 8 weeks as compared to saline injections [25]. The second trial revealed that botulinum neurotoxin injections were a more effective treatment option for patients with sciatica attributed to piriformis syndrome as compared to injections of corticosteroid plus lidocaine or placebo [25].…”