Botulinum toxin for subacute/chronic neck pain

Langevin, Pierre; Peloso, Paul M.; Lowcock, Janet; Nolan, May; Weber, Jeff; Gross, Anita; Roberts, John; Goldsmith, Charles H.; Graham, Nadine; Burnie, Stephen J; Haines, Ted

doi:10.1002/14651858.cd008626.pub3

Cited by 11 publications

(11 citation statements)

References 128 publications

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“…Five high quality RCTs indicated little or no effect of BoNT-A, and two very low quality RCTs suggested little or no difference between BoNT-A and placebo, both combined with physiotherapeutic exercise and analgesics, in patients with chronic neck pain [23]. A very low quality RCT showed little or no effect of BoNT-A in chronic cervicogenic headache [23].…”

Section: Resultsmentioning

confidence: 99%

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Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

et al. 2017

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BackgroundDespite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy of current pain-killers and prophylactic treatments stands among the main reasons for this phenomenon. Botulinum neurotoxin (BoNT) represents a well-established and licensed treatment for chronic migraine, but also an emerging treatment for other types of primary headache, trigeminal neuralgia, neuropathic pain, and an increasing number of pain conditions.MethodsWe searched and critically reviewed evidence for the efficacy of BoNT for the treatment of chronic pain.ResultsMeta-analyses and randomized controlled trials (RCTs) suggest that BoNT potentially represents a multi-purpose drug for the treatment of pain in several disorders due to a favorable safety profile and a long-lasting relief after a single injection.ConclusionsBoNT is an emerging treatment in different pain conditions. Future RCTs should explore the use of BoNT injection therapy combined with systemic drugs and/or physical therapies as new pain treatment strategies.

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Section: Resultsmentioning

confidence: 99%

“…A very low quality RCT showed little or no effect of BoNT-A in chronic cervicogenic headache [23]. Three RCTs showed no effect of BoNT-A in pain related to whiplash injury [24].…”

Section: Resultsmentioning

confidence: 99%

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

et al. 2017

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“…Nine randomized and quasi-randomized controlled trials (503 participants) were included in the systemic review performed by Langevin et al, (2011).…”

Section: 2 Current Clinical Experiencementioning

confidence: 99%

Botulinum toxin A, brain and pain

Matak

Lacković

2014

Progress in Neurobiology

147

119

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“…Tendría un rol en el manejo del dolor en la neuralgia del trigémino en pacientes refractarios a terapia médica como coadyuvante de ésta, sin embargo faltan mayores estudios para recomendar su uso rutinario en estos pacientes 16,17 . Existe una revisión sistemática que no recomienda su uso en manejo del dolor cervical crónico 18 .…”

Section: ) Patología Facialunclassified

Evidencia y uso actual de toxina botulínica en patología otorrinolaringológica

2015

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Botulinum toxin for subacute/chronic neck pain

Cited by 11 publications

References 128 publications

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

Botulinum toxin A, brain and pain

Evidencia y uso actual de toxina botulínica en patología otorrinolaringológica

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