Botulinum toxin in the management of chronic migraine: clinical evidence and experience

Escher, Claus; Paracka, Lejla; Dressler, Dirk; Kollewe, K.

doi:10.1177/1756285616677005

Cited by 68 publications

(60 citation statements)

References 73 publications

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“…5 This occurs when the body is overexposed to BTX, primarily when an individual receives too many treatments in too short of an interval without the proper waiting period between procedures. 15 Experts agree that a fixed treatment interval of 12 weeks between BTX injections, regardless of the location of treatment, provides the best therapeutic results and usually avoids the creation of antibodies. Exposing the body to BTX injections more frequently and shorter than the 12-week interval increases the risk of antibody development and subsequent treatment failure.…”

Section: Risks and Complications From Botulinum Toxin Use In The Neckmentioning

confidence: 99%

“…Exposing the body to BTX injections more frequently and shorter than the 12-week interval increases the risk of antibody development and subsequent treatment failure. 15 Chronic BTX usage can additionally cause a phenomenon known as dropped-head syndrome, a disabling condition caused by extreme weakness of the neck extensor musculature, leading to progressive cervical kyphosis and the inability to lift the head up against gravity. 4,5,16 This complication can occur when BTX injections are applied to the muscles of neck extension.…”

Section: Risks and Complications From Botulinum Toxin Use In The Neckmentioning

confidence: 99%

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Botulinum Toxin Injections as a Treatment of Postoperative Chronic Neck Pain Secondary to Cervical Spine Surgery

Meiling

Barndt

Raum

et al. 2020

Indian Journal of Neurosurgery

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Postoperative neck pain is a relatively common consequence of cervical spine surgeries such as anterior cervical discectomy with fusion and laminoplasty. Botulinum toxin injections are a relatively new treatment option to target muscle spasms, a possible cause of postoperative neck pain. This systematic review aims to evaluate the current literature highlighting the utilization of botulinum toxin for treating postoperative neck pain. The literature search resulted in one preliminary case–control trial, one case series and one case report. The use of Botox in these studies had promising benefits on postoperative neck pain, by reducing visual analog scores and improving objective measures of muscle tone such as cervical lordosis angle. While not seen in these studies, the use of botulinum toxin injections into the muscles of the region of the head, neck, and shoulder is not without risks such as focal muscle loss, joint instability, and respiratory and swallowing difficulty. With this in mind, while botulinum toxin may be a promising treatment for these patients, further well-designed studies are needed to further assess the treatments efficacy and safety in this patient population.

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Section: Risks and Complications From Botulinum Toxin Use In The Neckmentioning

confidence: 99%

Section: Risks and Complications From Botulinum Toxin Use In The Neckmentioning

confidence: 99%

Botulinum Toxin Injections as a Treatment of Postoperative Chronic Neck Pain Secondary to Cervical Spine Surgery

Meiling

Barndt

Raum

et al. 2020

Indian Journal of Neurosurgery

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“…W praktyce klinicznej istotniejsze jest różnicowanie choroby na postać występującą epizodycznie bądź przewlekle. Migrenę uważa się za schorzenie uwarunkowane genetycznie, związane z nieprawidłowym funkcjonowaniem kanałów jonowych w ośrodkach mózgu, zaburzeniami unerwienia oraz funkcji mózgowych naczyń krwionośnych [11].…”

Section: Toksyna Botulinowa Poza Medycyną Estetyczną I Dermatologiąunclassified

“…Sam zabieg polega początkowo na określeniu, które partie mięśni głowy uciskają lub w inny sposób podrażniają nerwy zaangażowane w rozwój migreny. Preparat wstrzykiwany jest do wybranych partii mięśni, które w ten sposób są blokowane i rozluźniane, a całkowita dawka nie powinna jednorazowo przekraczać 155-195 U. Zabieg obejmuje 31-39 określonych miejsc ostrzykiwań w okolicy czoła, skroni, szyi oraz karku, i zaleca się powtarzanie go co 12 tygodni [11].…”

Section: Toksyna Botulinowa Poza Medycyną Estetyczną I Dermatologiąunclassified

The possibilities of using botulinum toxin beyond the dermatology

Zwierzyńska¹,

Zawistowska²,

Pietrzak³

2018

Farm Pol.

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The possibilities of using botulinum toxin beyond the dermatology · Botulinum toxin which is a neurotoxin produced by the bacteria Clostridium botulinum, is one of the most active and best-known biological toxins. Its mechanism of action is associated with proteolysis of specific proteins and prevention of release acetylocholine at presynaptic terminals in neuromuscular junctions. Botulinum toxin is mainly used in aesthetic medicine for reduction of wrinkles and in excessive sweating. Recently, it has been also used beyond the dermatology e.g. in the treatment of migraines, dystonia, bruxism or overactive bladder. Moreover, its beneficial effects on reducing depression and weight loss in obese people are currently investigated in observation and clinical trials.

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“…In addition to these usages, BoTA is commonly used in medical applications to treat chronic myofascial pain, headache, urinary incontinence, and hyperhidrosis [21][22][23][24]. Lately, there have been reports demonstrating the effect of BoTA on ap survival, which was suggested to occur by increased vasodilation and angiogenesis via elevated hypoxia-inducible factor (HIF)1α and vascular endothelial growth factor (VEGF) [25,26].…”

Section: Introductionmentioning

confidence: 99%

Non-invasive intra-uterine administration of Botulinum Toxin A enhances endometrial angiogenesis and improves the rates of embryo implantation

Koo¹,

Yoon

Hong³

et al. 2020

Preprint

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Background. Endometrial angiogenesis plays crucial roles in determining the endometrial receptivity. Defects in endometrial receptivity often cause repeated implantation failure, which is one of the major unmet needs for infertility and contributes a major barrier to the assisted reproductive technology. Despite the numerous extensive research work, there are currently no effective evidence-based treatments to prevent or cure this condition.Method. As a non-invasive treatment strategy, Botulinum toxin A (BoTA) was administered into one side of mouse uterine horns and saline was infused into the other side of horns for the control. Impact of BoTA was assessed in the endometrium at 3 or 8 days after infusion.Results. We demonstrated that BoTA administration enhances the capacity of endothelial cell tube formation and sprouting. The intrauterine BoTA administration significantly induced endometrial angiogenesis displaying increased numbers of vessel formation and expression levels of related-marker genes. Moreover, BoTA intrauterine application promoted the endometrial receptivity and the rates of embryo implantation were improved with BoTA treatment with no morphologically retarded embryos. Conclusion. Intrauterine BoTA treatment has a beneficial effect on vascular reconstruction of functional endometrium prior to embryo implantation by increasing endometrial blood flow near the uterine cavity suggesting BoTA treatment as a potential therapeutic strategy for patients who are suffering from repeated implantation failure with the problems with endometrial receptivity.

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Botulinum toxin in the management of chronic migraine: clinical evidence and experience

Cited by 68 publications

References 73 publications

Botulinum Toxin Injections as a Treatment of Postoperative Chronic Neck Pain Secondary to Cervical Spine Surgery

Botulinum Toxin Injections as a Treatment of Postoperative Chronic Neck Pain Secondary to Cervical Spine Surgery

The possibilities of using botulinum toxin beyond the dermatology

Non-invasive intra-uterine administration of Botulinum Toxin A enhances endometrial angiogenesis and improves the rates of embryo implantation

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