Bottlenecks for genome-edited crops on the road from lab to farm

Scheben, Armin; Edwards, David

doi:10.1186/s13059-018-1555-5

Cited by 48 publications

(26 citation statements)

References 77 publications

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“…The difficulty associated with distinguishing between organisms presenting random natural mutations and those that have undergone new plant breeding techniques presents a significant obstacle to updating obsolete legislation [111]. The gap that exists between scientific knowledge regarding the impact of new plant breeding techniques on human and environmental health with the current legislation is a major bottleneck of the expansion of (epi)genome-edited crops [113].…”

Section: Legislationmentioning

confidence: 99%

Induced Methylation in Plants as a Crop Improvement Tool: Progress and Perspectives

et al. 2020

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The methylation of gene promoters is an epigenetic process that can have a major impact on plant phenotypes through its control of gene expression. This phenomenon can be observed as a response to stress, such as drought, cold/heat stress or pathogen infection. The transgenerational heritability of DNA methylation marks could enable breeders to fix beneficial methylation patterns in crops over successive generations. These properties of DNA methylation, its impact on the phenotype and its heritability, could be used to support the accelerated breeding of improved crop varieties. Induced DNA methylation has the potential to complement the existing plant breeding process, supporting the introduction of desirable characteristics in crops within a single generation that persist in its progeny. Therefore, it is important to understand the underlying mechanisms involved in the regulation of gene expression through DNA methylation and to develop methods for precisely modulating methylation patterns for crop improvement. Here we describe the currently available epigenetic editing tools and their advantages and limitations in the domain of crop breeding. Finally, we discuss the biological and legislative limitations currently restricting the development of epigenetic modification as a crop improvement tool.

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Section: Legislationmentioning

confidence: 99%

Induced Methylation in Plants as a Crop Improvement Tool: Progress and Perspectives

et al. 2020

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“…The discovery of target genes related to important agronomic traits and further developments in genome editing are therefore the two most important tasks. Although low cost genome sequencing technology has yielded more than 200 plant genome sequences [39] , there are only a few candidate genes for editing. A bottleneck to discovering target genes is in linking the very large amount of available sequence data to specific traits.…”

Section: Challenges and Prospectsmentioning

confidence: 99%

Genome-edited crops: how to move them from laboratory to market

Kunling¹,

Gao²

2020

Front. Agr. Sci. Eng.

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“…In natural environments, traits have also been successfully linked to genetic loci through sequencing of contrasting species populations in different habitats [208]. Whole genome sequencing and resequencing is becoming increasingly cheap and available, with major strides being made in both improving genomic resources available for the Brassica crop genomes [209][210][211][212] and in the availability of additional genomic resources for Brassica wild relatives [213,214]. As previously mentioned, genetic transformation and genome editing protocols have already been established for many of the Brassica crop species [172,174,175].…”

Section: Future Outlookmentioning

confidence: 99%

Interspecific Hybridization for Brassica Crop Improvement

2019

Crop Breed Genet Genom.

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Interspecific hybridization is widespread in nature, where it can lead to either the production of new species or to the introgression of useful adaptive traits between species. In agricultural systems, there is also great potential to take advantage of this process for targeted crop improvement. In the Brassica genus, several crop species share close relationships: rapeseed (Brassica napus) is an ancestral hybrid between turnip (B. rapa) and cabbage (B. oleracea), and mustard species B. juncea, B. carinata and B. nigra share genomes in common. This close relationship, plus the abundance of wild relatives and minor crop species in the wider Brassiceae tribe which readily hybridize with the Brassica crop species, makes this genus an interesting example of the use of interspecific hybridization for crop improvement. In this review we introduce the Brassica crop species and their wild relatives, barriers to interspecific and intergeneric hybridization and methods to overcome them, summarize previous successful and unsuccessful attempts at the use of interspecific hybridization for crop improvement in Brassica, and provide information about resources available to breeders wishing to take advantage of this method in the Brassica genus.

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Bottlenecks for genome-edited crops on the road from lab to farm

Cited by 48 publications

References 77 publications

Induced Methylation in Plants as a Crop Improvement Tool: Progress and Perspectives

Induced Methylation in Plants as a Crop Improvement Tool: Progress and Perspectives

Genome-edited crops: how to move them from laboratory to market

Interspecific Hybridization for Brassica Crop Improvement

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