Botryane sesquiterpenes and binaphthalene tetrols from endophytic fungi associated to the marine red algae Asparagopsis taxiformis

Medina, Rebeca Previate; Silva, Alexandra; Andersen, R. J.; Araújo, AR; Silva, Dhs

doi:10.1055/s-0036-1596629

Cited by 2 publications

(1 citation statement)

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“…One of these is the Nuclei of Bioassays, Biosynthesis and Ecophysiology of Natural Products (NuBBE, UNESP -Araraquara/Brazil) research group, which has been involved in the latest advances in natural product chemistry, including new analytical methods for metabolomics, proteomics, biosynthesis and medicinal chemistry. One of the focus of the group is the search for biologically active compounds from Brazilian plant species, with an emphasis on Cerrado and the Atlantic forest, endophytic fungi and marine species [132,133]. Beside secondary metabolites, NuBBE has invested in a new topic, and recently has been dedicated to the studies on orbitides and cyclotides from Brazilian plant species [134][135][136].…”

Section: -Taiwan Indigenous Plant Database (Tipdb-3d)mentioning

confidence: 99%

A primer on natural product-based virtual screening

Koulouridi

Valli

Ntie‐Kang

et al. 2019

Physical Sciences Reviews

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Databases play an important role in various computational techniques, including virtual screening (VS) and molecular modeling in general. These collections of molecules can contain a large amount of information, making them suitable for several drug discovery applications. For example, vendor, bioactivity data or target type can be found when searching a database. The introduction of these data resources and their characteristics is used for the design of an experiment. The description of the construction of a database can also be a good advisor for the creation of a new one. There are free available databases and commercial virtual libraries of molecules. Furthermore, a computational chemist can find databases for a general purpose or a specific subset such as natural products (NPs). In this chapter, NP database resources are presented, along with some guidelines when preparing an NP database for drug discovery purposes.

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Section: -Taiwan Indigenous Plant Database (Tipdb-3d)mentioning

confidence: 99%

A primer on natural product-based virtual screening

Koulouridi

Valli

Ntie‐Kang

et al. 2019

Physical Sciences Reviews

View full text Add to dashboard Cite

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High quality genome sequences of thirteen Hypoxylaceae (Ascomycota) strengthen the phylogenetic family backbone and enable the discovery of new taxa

et al. 2020

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The Hypoxylaceae (Xylariales, Ascomycota) is a diverse family of mainly saprotrophic fungi, which commonly occur in angiosperm-dominated forests around the world. Despite their importance in forest and plant ecology as well as a prolific source of secondary metabolites and enzymes, genome sequences of related taxa are scarce and usually derived from environmental isolates. To address this lack of knowledge thirteen taxonomically well-defined representatives of the family and one member of the closely related Xylariaceae were genome sequenced using combinations of Illumina and Oxford nanopore technologies or PacBio sequencing. The workflow leads to high quality draft genome sequences with an average N50 of 3.0 Mbp. A backbone phylogenomic tree was calculated based on the amino acid sequences of 4912 core genes reflecting the current accepted taxonomic concept of the Hypoxylaceae. A Percentage of Conserved Proteins (POCP) analysis revealed that 70% of the proteins are conserved within the family, a value with potential application for the definition of family boundaries within the order Xylariales. Also, Hypomontagnella spongiphila is proposed as a new marine derived lineage of Hypom. monticulosa based on in-depth genomic comparison and morphological differences of the cultures. The results showed that both species share 95% of their genes corresponding to more than 700 strain-specific proteins. This difference is not reflected by standard taxonomic assessments (morphology of sexual and asexual morph, chemotaxonomy, phylogeny), preventing species delimitation based on traditional concepts. Genetic changes are likely to be the result of environmental adaptations and selective pressure, the driving force of speciation. These data provide an important starting point for the establishment of a stable phylogeny of the Xylariales; they enable studies on evolution, ecological behavior and biosynthesis of natural products; and they significantly advance the taxonomy of fungi.

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Botryane sesquiterpenes and binaphthalene tetrols from endophytic fungi associated to the marine red algae Asparagopsis taxiformis

Cited by 2 publications

References 0 publications

A primer on natural product-based virtual screening

A primer on natural product-based virtual screening

High quality genome sequences of thirteen Hypoxylaceae (Ascomycota) strengthen the phylogenetic family backbone and enable the discovery of new taxa

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