Both solubility and chemical stability of curcumin are enhanced by solid dispersion in cellulose derivative matrices

Li, Bin; Konecke, Stephanie; Wegiel, Lindsay A.; Taylor, Lynne S.; Edgar, Kevin J.

doi:10.1016/j.carbpol.2013.07.017

Cited by 152 publications

(76 citation statements)

References 33 publications

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“…In this study, the time of differentiated cells gradually stopped path are programmed cell death after treatment with curcumin formulation dendrosome, Bax gene expression levels increased by 50% indicated that the mitochondrial death pathway gradual activation of the indicator programmed cell. To increase the stability and solubility of curcumin, Konecks et al, after examining the antitumor activity of liposomal curcumin on pancreatic cancer cells found that curcumin inhibits the growth of cells in the pancreas [28].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Effect on the Expressional Profile of OCT4, Nanog and Nucleostemin Genes in AGS (Adenocarcinoma) Cancer Cell Line

Bagrezaei

Mahmoodi

Hajizadeh

et al. 2016

Zahedan J Res Med Sci

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Section: Discussionmentioning

confidence: 99%

Curcumin Effect on the Expressional Profile of OCT4, Nanog and Nucleostemin Genes in AGS (Adenocarcinoma) Cancer Cell Line

Bagrezaei

Mahmoodi

Hajizadeh

et al. 2016

Zahedan J Res Med Sci

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“…Similarly, characteristic peaks of CUR in the physical mixture with HPMC 4000 and HPMC 6 were also at 3507, 3400, 1628, 1607 cm À1 in Fig. 5B and C. The peaks at 3570 cm À1 and 3400 cm À1 were attributed to AOH stretching [26]. Meanwhile, the peaks at 1628 cm À1 and 1607 cm À1 were attributed to C@O and C@C of CUR, respectively [27].…”

Section: Molecular Interactionsmentioning

confidence: 97%

Modulation of particle size and molecular interactions by sonoprecipitation method for enhancing dissolution rate of poorly water-soluble drug

Tran

2015

Ultrasonics Sonochemistry

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Aim of present work was to originally elucidate the roles of ultrasonication method for modulating the size and molecular interactions in controlling release of poorly water-soluble drug. Curcumin was chosen as a model drug. Three types of polymers were investigated as carriers for preparation of polymeric nanoparticles under various ultrasonication conditions and polymer-drug ratios. Changes in drug crystallinity, particle size, and molecular interactions which would be factors enhancing drug dissolution rate were evaluated. Amorphous form of curcumin, size reduction of nanoparticles and interaction between drug and polymer in formulations were attributed to improved drug dissolution rate. Particle size was strongly affected by polymer type, polymer-drug ratio and ultrasonication conditions. Interestingly, control of those factors caused differences in molecular interactions of the hydroxyl groups and then, highly affected particle size of the nanoparticles. It was obvious that there was a reciprocal influence between the drug-polymer interactions and particle size of the nanoparticles. This relation could be modulated by polymers and ultrasonication processes for enhancing drug dissolution rate.

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“…Ancak kurkuminin biyo aktivitelerinin çeşitliliğine ve hastalıkları önleme ve tedavi etme potansiyeline rağmen düşük çözünürlüğü ve sulu çözeltilerdeki kararsızlığı, yetersiz doku emilimi, alkali pH da degradasyona uğraması, hızlı sistemik eliminasyonu nedeniyle düşük biyoyararlılık gösterir ve bu nedenle terapötik bir ajan olarak kullanılmasını engelleyen en önemli problemi oluşturur (Aggarwal and Harikumar, 2009;Mohanty and Sahoo, 2010 (Yadav et al, 2010;Gao et al, 2011;Li et al, 2013).…”

Section: şEkil 1 Kurkuminin Kimyasal Yapısıunclassified

The Role of Curcumin-Loaded Solid Lipid Nanoparticles Labeled with Tc-99m in the Liver-Spleen Scintigraphy

Yenilmez¹,

Ayan²,

Gündoğdu³

et al. 2016

jist

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ÖZET: Son zamanlarda, hastalıkların tanı ve tavisini kolaylaştırmak amacıyla, nanoteknoloji ve moleküler görüntüleme alanları, çok fonksiyonlu nanopartiküllerin oluşturulması ile birleştirilmiştir. Nanopartiküllerden oluşturulan yeni nesil görüntüleme ajanlarının sahip olduğu çok yönlü ve eşsiz özelliklerinden faydalanan alanlardan biriside nükleer tıp alanıdır. Yapılan bu çalışmada; kurkumin yüklü katı lipit nanopartiküllerin (K-KLN) karaciğer ve dalak sintigrafisinde kullanılabilirliliği araştırıldı. Öncelikle, kurkumin yüklü katı lipit nanopartiküller (K-KLN) mikroemülsiyon ve düşük-sıcaklıkda katılaştırma yöntemiyle hazırlandı. Lazer kırınımı (LD) analizi ile partikül boyutu belirlendi. Termogravimetrik analizi (TGA) ile K-KLN'lerin sıcaklığa karşı stabil olduğu gözlemlendi. Daha sonra K-KLN'ler Teknesyum-99m ( 99m Tc) ile radyoaktif olarak işaretlendi. İnce katman kromatografi yöntemi ile radyoaktif işaretleme etkinliği %95'den daha fazla olarak bulundu. ABSTRACT:Recently, nanotechnology and molecular imaging fields are integrated to facilitate the diagnosis and the treatment of diseases with create multi-functional nanoparticles. Nuclear medicine is one of the fields that benefit from the multi-faceted and unique characteristics of new generation imaging agents that are made of nanoparticles. This study investigated the feasibility of using curcumin-loaded SLNs in liver and spleen scintigraphy. Initially, the curcumin-loaded solid lipid nanoparticles (C-SLN) were prepared using microemulsion and solidification at low temperatures. The size of the C-SLN particle is measured by Laser diffraction (LD) method. Moreover, by applying thermogravimetric analysis (TGA) it is observed that C-SLN particles are stable with temperature variation. Then, they are radiolabeled with Technetium-99m ( 99m Tc). Using the thin-layer chromatography method, the radiolabeling efficiency was found to be higher than 95%. Tc-C-SLNs were injected to the rabbit intravenously (i.v.) and using a gamma camera, dynamic images were recorded. Liver and spleen were clearly displayed in these dynamic images. In addition to scintigraphic findings, the presence of 99m Tc-C-SLNs in the liver and the spleen was observed in the ex vivo biodistribution studies and the analyses performed under the fluorescence microscope.

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Both solubility and chemical stability of curcumin are enhanced by solid dispersion in cellulose derivative matrices

Cited by 152 publications

References 33 publications

Curcumin Effect on the Expressional Profile of OCT4, Nanog and Nucleostemin Genes in AGS (Adenocarcinoma) Cancer Cell Line

Curcumin Effect on the Expressional Profile of OCT4, Nanog and Nucleostemin Genes in AGS (Adenocarcinoma) Cancer Cell Line

Modulation of particle size and molecular interactions by sonoprecipitation method for enhancing dissolution rate of poorly water-soluble drug

The Role of Curcumin-Loaded Solid Lipid Nanoparticles Labeled with Tc-99m in the Liver-Spleen Scintigraphy

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