Bos taurus and Bos indicus (Sahiwal) calves respond differently to infection with Theileria annulata and produce markedly different levels of acute phase proteins

Glass, Elizabeth J.; Preston, Patricia M.; Springbett, Anthea; Craigmile, Susan; Kirvar, E.; Wilkie, Gwen; Brown, C.G.D.

doi:10.1016/j.ijpara.2004.12.006

Cited by 100 publications

(68 citation statements)

References 42 publications

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“…In a study conducted by Nazifi et al (2010) the blood samples of 24 indigenous and 26 Holstein cattle were obtained and Theileria infection was diagnosed based on hematological, biochemical and microbiological tests, clinical signs and epidemiological evidences; Iranian indigenous cattle had lower parasitemia rate, weaker response to T. annulata infection, milder clinical manifestations and significantly lower levels of acute phase proteins in comparison with Holstein and these results have conformity with our achievements. Glass et al (2005) and Terada et al (1995) also separately performed experiments between different cattle breeds infected to T. annulata and showed statistically significant differences among the pure and native breeds, as in our study. Ananda et al (2009) mentioned high prevalence of T. annulata in cattles of 4-6 years of age that has disagreement with our results; We perceived that the mean age of PCR positive cattles were between 1 and 2 years.…”

Section: Discussionsupporting

confidence: 73%

Detection of Theileria annulata carriers in Holstein–Friesian (Bos taurus taurus) and Sistani (Bos taurus indicus) cattle breeds by polymerase chain reaction in Sistan region, Iran

et al. 2015

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Theileria annulata is common in tropical and subtropical regions especially in Iran and causes great economic losses in cattle industry. In Iran the epidemiological aspects of bovine theileriosis in different breeds of cattle is poorly understood. The aim of present study is comparison of the number of T. annulata carriers in the two major cattle breeds (Holstein-Friesian and Sistani) in Sistan of Iran by giemsa and polymerase chain reaction (PCR) methods. During winter 2013, 160 native cattle, from the two major breeds in Sistan, with the mean age of more than one year and without typical clinical symptoms of theileriosis were selected. At first, a thin layer smear was held from their ear sublime vein blood for Giemsa staining method. In order to do PCR assay, jugular vein blood sample of each cow was taken. The PCR employs primers specific for the 721-bp gene fragment encoding the 30-kDa major merozoite surface antigen of T. annulata. By PCR method, 38 (47.5 %) Holstein blood samples and 22 (27.5 %) Sistani blood samples had DNA of T. annulata and considered positive (The correlation was significant at values of P \ 0.05). By checking 160 blood smears with light microscope and lens 9 100, only 10 samples (6.25 %) were positive for T. annulata. Statistical comparison between PCR and smear method showed that the PCR method is more sensitive and accurate in comparison to Giemsa staining method to diagnose the asymptomatic carriers of T. annulata.

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Section: Discussionsupporting

confidence: 73%

Detection of Theileria annulata carriers in Holstein–Friesian (Bos taurus taurus) and Sistani (Bos taurus indicus) cattle breeds by polymerase chain reaction in Sistan region, Iran

et al. 2015

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“…The production of SAA and α 1 -acid glycoprotein correlated strongly with each other, and also with some clinical features of disease severity including the time of fever, development of leukopenia, parasitemia rate, and mortality. Glass et al (2005) reported that Bos taurus and Bos indicus (Sahiwal) calves respond differently to infection with T. annulata and produce markedly different levels of APPs. Following experimental infection with T. annulata sporozoites, a group of Sahiwal calves all survived without treatment, with significantly lower maximum temperatures and lower parasitemia rate than a group of Holstein calves, which all showed severe clinical manifestation.…”

Section: Discussionmentioning

confidence: 99%

“…Glass et al (2003) reported that T. annulata causes severe pathology in susceptible cattle by inducing high levels of proinflammatory cytokines. Glass et al (2005) reported that Bos taurus and Bos indicus (Sahiwal) calves respond differently to infection with T. annulata and produce markedly different levels of APPs. Glass and Jensen (2007) reported that Bos indicus (Sahiwal), which originates in a T. annulata-endemic area, is more resistant to the parasite.…”

Section: Introductionmentioning

confidence: 99%

Study on acute phase proteins (haptoglobin, serum amyloid A, fibrinogen, and ceruloplasmin) changes and their diagnostic values in bovine tropical theileriosis

et al. 2009

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This study was conducted to assess the pattern of changes and the relative value of acute phase proteins (haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin and fibrinogen) in bovine tropical theileriosis. The diseased group comprised 50 dairy Holstein cattle, 2-3 years old, naturally infected with Theileria annulata. Infected animals were divided into four subgroups with different parasitemia rates (<1%, 1-3%, 3-5%, >5%). As a control group, 20 uninfected cattle were also sampled. Blood samples were collected and all measurements were done using validated methods. There were significant differences in red blood cells (RBCs), packed cell volume (PCV), hemoglobin (Hb) and concentrations of Hp, SAA, ceruloplasmin and fibrinogen between healthy cattle and those infected with T. annulata with different parasitemia rates (P < 0.05). As the parasitemia rate increased in infected cattle, a significant decrease was observed in RBCs, PCV, and Hb. In contrast, with increase in the parasitemia rate, a significant increase in the mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), Hp, SAA, ceruloplasmin, and fibrinogen was evident. The optimal cut-off point was set by the receiver operating characteristics (ROC) method to >5.68 microg/ml for SAA, >0.16 g/l for Hp, >0.064 g/l for ceruloplasmin and >4.00 g/l for fibrinogen with corresponding 84% sensitivity and 100% specificity for SAA, 76% sensitivity and 100% specificity for Hp, 84% sensitivity and 80% specificity for ceruloplasmin and 40% sensitivity and 100% specificity for fibrinogen. SAA had the highest sensitivity and specificity and was diagnosed to be a suitable indicator of APPs changes in bovine theileriosis.

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“…Only cross breed cattle scored positive by blood smear the logical conclusion being that this relates to a higher parasitaemia in crossbreed animals. Whether lower levels of pathogen burden are linked to genetic resistance of natives vs cross breeds requires to be established, although is indicated from previous studies [27,28]. Mechanisms of breed resistance against T. annulata are known to be manifest as a reduction in clinical paramaters associated with an alteraltion in the level of proinflammatory cytokines [29].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Tick-borne Pathogens in Co-grazed Dairy Bovines Differs by Region and Host-type in Tamil Nadu, India

Ponnudurai¹,

Larcombe²,

Velusamy³

et al. 2017

J Adv Dairy Res

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In India, disease of cattle caused by tick-borne pathogens (TBP) constrains the rearing of high yielding Bos taurus dairy breeds that often develop clinical, fatal disease. Bos indicus and bufflao show resistance to TBP infection, and this has led to a policy of rearing crossbred indicus-taurus cattle. On dairy farms, co-grazing more resistant animals alongside crossbreeds could contribute positively (by removing potentially infective ticks) or negatively (by acting as a reservoir for infection). We investigated epidemiological factors that contribute to the prevalence of five tick-borne pathogens with links to milk-yield in co-grazed host types in dairy farms of two regions of Tamil Nadu, India; a region of high dairy production importance. A high prevalence of T. annulata and Anaplasma spp. was detected, but with lower prevalence in the Cauvery Delta than in the Northwestern zone. A strict host-type association with prevalence was observed: buffaloes had lower prevalence of TBP than cattle; and native breeds had a lower prevalence of Anaplasma spp. than crossbreeds. The results indicate that while susceptibility to becoming a carrier animal for TBP depends on exposure to ticks; aspects of resistance are determined by host type independent of tick exposure. There was no clear evidence that co-grazing, with more resistant host types, will provide a positive contribution (protective effect) to crossbreeds with greater milk productivity.

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Bos taurus and Bos indicus (Sahiwal) calves respond differently to infection with Theileria annulata and produce markedly different levels of acute phase proteins

Cited by 100 publications

References 42 publications

Detection of Theileria annulata carriers in Holstein–Friesian (Bos taurus taurus) and Sistani (Bos taurus indicus) cattle breeds by polymerase chain reaction in Sistan region, Iran

Detection of Theileria annulata carriers in Holstein–Friesian (Bos taurus taurus) and Sistani (Bos taurus indicus) cattle breeds by polymerase chain reaction in Sistan region, Iran

Study on acute phase proteins (haptoglobin, serum amyloid A, fibrinogen, and ceruloplasmin) changes and their diagnostic values in bovine tropical theileriosis

Prevalence of Tick-borne Pathogens in Co-grazed Dairy Bovines Differs by Region and Host-type in Tamil Nadu, India

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