Boronic Acid-Functionalized Two-Dimensional MoS₂ at Biointerfaces

Abstract

While noncovalent interactions at two-dimensional nanobiointerfaces are extensively investigated, less knowledge about covalent interactions at this interface is available. In this work, boronic acid-functionalized 2D MoS2 was synthesized and its covalent multivalent interactions with bacteria and nematodes were investigated. Polymerization of glycidol by freshly exfoliated MoS2 and condensation of 2,5-thiophenediylbisboronic acid on the produced platform resulted in boronic acid-functionalized 2D MoS2. The destructive interactions between 2D MoS2 and bacteria as well as nematodes were significantly amplified by boronic acid functional groups. Because of the high antibacterial and antinematodal activities of boronic acid-functionalized 2D MoS2, its therapeutic efficacy for diabetic wound healing was investigated. The infected diabetic wounds were completely healed 10 days after treatment with boronic acid-functionalized 2D MoS2, and a normal structure for recovered tissues including different layers of skin, collagen, and blood vessels was detected.

Functionalized MoS2-Based Nanomaterials for Cancer Phototherapy and Other Biomedical Applications

“…While noncovalent interactions at 2D nanobiointerfaces are extensively investigated, less knowledge about covalent interactions at this interface is available. In one work, researchers synthesized boronic acid-functionalized 2D MoS 2 and investigated its covalent multivalent interactions with bacteria and nematodes . The 2D MoS 2 was freshly exfoliated and then polymerized with glycidol onto the surface, forming the polyglycerol-coated MoS 2 , which have the cis-diol functional groups.…”

“…In one work, researchers synthesized boronic acid-functionalized 2D MoS 2 and investigated its covalent multivalent interactions with bacteria and nematodes. 93 The 2D MoS 2 was freshly exfoliated and then polymerized with glycidol onto the surface, forming the polyglycerol-coated MoS 2 , which have the cis-diol functional groups. Then, 2,5-thiophenediylbisboronic acid was attached to the functional groups, forming a boronic acid functionalized 2D MoS 2 platform.…”

Two‐Dimensional Silicene/Silicon Nanosheets: An Emerging Silicon‐Composed Nanostructure in Biomedicine

“…In addition to the mostly explored anticancer applications of versatile 2D nanosheets with different compositions and functionalities, these nanosheets have also been explored in the treatment of infection-related diseases, [144][145][146][147][148][149][150][151] which is now the urgent need in clinical practice because of the presence of antibiotic resistance in bacteria. On this ground, 2D graphene-like SiNSs were directly fabricated from their pristine silicon crystal by the ultrasonication-enabled selective delamination (Figure 9a).…”

Functionalized Graphene Platforms for Anticancer Drug Delivery

“…8,15,16 Different types of nanomaterials such as organic nanoparticles (polymeric micelles, liposomes, and dendrimers) inorganic nanoparticles (quantum dots, carbon nanotubes, magnetic and metal nanoparticles), 2D nanomaterials (graphene and its derivatives, molybdenum disulfide, boron nitride, black phosphorus nanosheets, transition-metal dichalcogenides, transition metal oxides, metal organic frameworks, layered double hydroxides), nanocomposites, and nanogels have been used for this purpose. [17][18][19][20][21][22][23][24][25][26][27][28] To address these problems, anticancer drug delivery systems based on two-dimensional nanomaterials are developed and their ability to target anticancer drugs into tumors is investigated. 29 Graphene-based nanomaterials due to their excellent physicochemical and biological properties including high loading capacity, photothermal property, and fast cellular uptake have been used to improve current chemotherapies.…”