Boron Neutron-Capture Therapy (BNCT) for Glioblastoma Multiforme (GBM) Using the Epithermal Neutron Beam at the Brookhaven National Laboratory

Chadha, Manjeet; Capala, Jacek; Coderre, Jeffrey A.; Elowitz, Eric; Iwai, Junichi; Joel, Darrel D.; Liu, Hungyuan B.; Wielopolski, Lucian; Chanana, A. D.

doi:10.1016/s0360-3016(97)00891-2

Cited by 100 publications

(38 citation statements)

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“…Numerous methods have been developed to increase the biological dose to the tumor area while sparing surrounding normal tissue. These include the use of neutrons [9,14], heavy particles [6], boron neutron capture therapy [2], radiosensitizers [21,26], hyperthermia [33], modified fractionation schemes [23], conformal radiation therapy [16], high-dose-rate interstitial brachytherapy [29], iodine-125 seeds [13,32], stereotactic radiosurgery [4,8], and -last but not least -IORT [7,20,25]. The vast majority of these studies showed an increased rate of radiation necrosis without an improvement in overall survival.…”

Section: Discussionmentioning

confidence: 99%

12 Years’ Experience with Intraoperative Radiotherapy (IORT) of Malignant Gliomas

et al. 2005

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Section: Discussionmentioning

confidence: 99%

12 Years’ Experience with Intraoperative Radiotherapy (IORT) of Malignant Gliomas

et al. 2005

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“…Toxicity related to BPA administration was not observed, although grade 1 and 2 toxicity was reported, related to the radiation. Chadha et al concluded that it was feasible to perform BPA-BNCT using an epithermal neutron beam 15 . A second phase I/II trial was aimed at evaluating both safety and palliation The authors stated that, since the mean survival time for BPA-BNCT was not significantly higher than for external beam irradiation, higher radiation doses should be used 16 .…”

Section: Clinical Trials With Tumor Selective 10-boron Carriersmentioning

confidence: 99%

Boron neutron capture therapy for glioblastoma multiforme

et al. 2005

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The BNCT is a promising and possibly curative method of treating GBM, but at present this procedure is far from perfect. Because of the lack of selectivity of the boron carriers, it appears so far that radiation toxicity limits the radiation dose, so that tumor damage is modest. Current investigations and developments are aimed at targeting the boron carriers to the tumor, in order to limit the damage to the healthy, surrounding tissue.

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“…An experimental use of neutrons, boron neutron capture therapy (BNCT), is undergoing clinical trials in glioblastoma multiforme at the Brookhaven National Laboratory [13].…”

Section: Technical Aspectsmentioning

confidence: 99%

Advances in stereotactic radiosurgery for brain neoplasms

M¹

2001

Curr Neurol Neurosci Rep

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It has been nearly half a century since Leksell introduced brain radiosurgery. In the past decade, the procedure has become widely used as both a primary and adjuvant treatment. Radiosurgery is now commonly employed for arteriovenous malformations, brain metastases, and several benign lesions. Its use in primary brain malignancy remains of uncertain benefit. Improvements in imaging, hardware, and software promise an even greater role for the technique.

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Boron Neutron-Capture Therapy (BNCT) for Glioblastoma Multiforme (GBM) Using the Epithermal Neutron Beam at the Brookhaven National Laboratory

Cited by 100 publications

References 27 publications

12 Years’ Experience with Intraoperative Radiotherapy (IORT) of Malignant Gliomas

12 Years’ Experience with Intraoperative Radiotherapy (IORT) of Malignant Gliomas

Boron neutron capture therapy for glioblastoma multiforme

Advances in stereotactic radiosurgery for brain neoplasms

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