Boron doped diamond microelectrodes arrays for electrochemical detection in HPLC

Mahé, Éric; Devilliers, Didier; Dardoize, F.

doi:10.1016/j.talanta.2014.10.028

Cited by 19 publications

(3 citation statements)

References 43 publications

(47 reference statements)

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“…Detection limits between 0.6 and 1 ppb were achieved, comparable with well-established detection methods as HPLC-fluorescence. Afterwards, the possibility of detecting of species of environmental (Treetepvijit et al, 2006; Pecková et al, 2009), pharmaceutical (Siangproh et al, 2010; Maixnerová et al, 2012; Mahé et al, 2015; Long et al, 2017) and biological (Bartošová et al, 2011; Kotani et al, 2011; Zhang et al, 2016) interests using a BDD electrode without electrochemical pretreatment coupled to HPLC systems have been also presented.…”

Section: Bdd Electrode Coupled To Hplc Systemsmentioning

confidence: 99%

Boron Doped Diamond Electrodes in Flow-Based Systems

et al. 2019

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Boron-doped diamond (BDD) electrodes present several notable properties, such as the largest potential window of all electrode materials (especially in anodic potentials), low background and capacitive currents, reduced fouling compared to other electrodes, mechanical robustness, and good stability over time. On the other hand, flow-based systems are known as well-established approaches to minimize reagent consumption and waste generation and with good compromise between sample throughput and analytical performance (mechanization of chemical assays). This review focuses on the use of BDD electrodes for electrochemical detection in flow systems, such as flow injection analysis (FIA), batch injection analysis (BIA), high performance liquid chromatography (HPLC), and capillary electrophoresis (CE). The discussion deals with the historical evolution of BDD, types of electrochemical pre-treatments (cathodically/H-terminated or anodically/O-terminated), cell configurations, and analytical performance. Articles are discussed in chronological order and subdivided according to the type of flow system: FIA, BIA, HPLC, and CE.

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Section: Bdd Electrode Coupled To Hplc Systemsmentioning

confidence: 99%

Boron Doped Diamond Electrodes in Flow-Based Systems

et al. 2019

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“…Electrochemical detection represents a cost-effective solution in the analysis of electroactive compounds such as various biomarkers, neurotransmitters, , nucleic acids, antioxidants, saccharides, drugs, etc. As ECD probes only species that are electroactive at the applied potential, it often offers higher selectivity than spectrophotometric detection − and much lower running costs compared with MS. , Nevertheless, the determinations of low concentrations of analytes that require the use of high detection potentials are particularly challenging. Piperazine antihistamines fall into this category, as they are oxidizable at relatively high potentials, approaching the anodic potential limit of common electrode materials.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical HPLC Determination of Piperazine Antihistamine Drugs Employing a Spark-Generated Nickel Oxide Nanoparticle-Modified Carbon Fiber Microelectrode

Belbasi,

Petr,

Sevcik

et al. 2024

ACS Omega

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In this work, we demonstrate a sensitive highperformance liquid chromatography (HPLC) method for the determination of piperazine antihistamine drugs employing innovative electrochemical detection based on a spark-generated nickel oxide nanoparticle-modified carbon fiber microelectrode built into a miniaturized electrochemical detector. The direct carbon fiber-tonickel plate electrode spark discharge, carried at 0.8 kV DC, with the nickel electrode connected to the negative pole of the high-voltage power supply, provides extremely fast (1 s) in situ tailoring of the carbon fiber microelectrode surface by nickel oxide nanoparticles. It has been found that nickel oxide nanoparticles exhibit an electrocatalytic effect toward the piperazine moiety electrooxidation process, as confirmed by voltammetric experiments, revealing the shift in the peak potential from 1.25 to 1.09 V versus Ag/AgCl. Cetirizine, cyclizine, chlorcyclizine, flunarizine, meclizine, and buclizine were selected as sample piperazine antihistamine drugs, while diclofenac served as an internal standard. The isocratic reversed-phase separation of the above set was achieved within 15 min using an ARION-CN 3 μm column with a binary mobile phase consisting of 50 mM phosphate buffer (pH 3) and methanol (45/55, v/v). The limits of detection (LOD) were within the range of 3.8−120 nM (for cyclizine and buclizine) at E = +1500 mV (vs Ag/AgCl), while the response was linear within the concentration range measured up to 5 μmol L −1 . The method was successfully applied to the determination of piperazine antihistamine drugs in spiked plasma samples.

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“…These electrodes have received considerable attention since the pioneering investigations in the early 1980s [2,3]. They are commonly used in the analyte detection of electroactive species, especially certain organic molecules [4]. Microelectrodes have several advantages over their conventional counterparts, such as their chemical stability, excellent electrical properties, and possibility for miniaturized electrochemical sensors [5].…”

Section: Introductionmentioning

confidence: 99%