Boron‐11 MRI and MRS of intact animals infused with a boron neutron capture agent

Kabalka, George W.; Davis, M.A.F.; Bendel, Peter

doi:10.1002/mrm.1910080214

Cited by 48 publications

(19 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 11 B signal from BSH is considerably broadened in biological environments, such as in serum solutions and in laboratory animals [27][28][29] (Fig. 2).…”

Section: B-relaxation Spectroscopy Imagingmentioning

confidence: 99%

Biomedical applications of10B and11B NMR

Bendel

2005

NMR Biomed.

Self Cite

View full text Add to dashboard Cite

This review focuses mainly on the detection and investigation of molecules used for boron neutron capture therapy (BNCT) by 10 B and 11 B NMR. In this binary radiation treatment, boron-containing molecules (also called 'BNCT agents') enriched in the 10 B isotope, are targeted to the tumor, and irradiated with thermal or epithermal neutrons. Capture of these neutrons by 10 B nuclei generates cell-damaging radiation, confined to single cell dimensions. NMR research efforts have primarily been applied in two directions: first, to investigate the metabolism and pharmaco-kinetics of BNCT agents invivo, and second, to use localized NMR spectroscopy and/or MRI for non-invasive mapping of the administered molecules in treated animals or patients. While the first goal can be pursued using 11 B NMR for natural-abundance samples (80% 11 B / 20% 10 B), molecules used in the actual treatment are >95% enriched in 10 B, and must therefore be detected by 10 B NMR. Both 10 B (spin 3) and 11 B (spin 3/2) are quadrupolar nuclei, and their typical relaxation times, in common BNCT agents in biological environments, are rather short. This poses some technical challenges, particularly for MRI, which will be reviewed, along with possible solutions. The first attempts at 11 B NMR and MRI detection of BNCT agents in biological tissue were conducted over a decade ago. Since then, results from 11 B MRI in laboratory animals and in humans have been reported, and 11 B NMR spectroscopy provided interesting and unique information about the metabolism of some BNCT agents in cultured cells. 10 B NMR was applied either 'indirectly' (in double-resonance experiments involving coupled protons), but also by direct 10 B MRI in mice. However, no results involving the NMR detection of 10 B-enriched compounds in treated patients have been reported yet.

show abstract

“…The 11 B signal from BSH is considerably broadened in biological environments, such as in serum solutions and in laboratory animals [27][28][29] (Fig. 2).…”

Section: B-relaxation Spectroscopy Imagingmentioning

confidence: 99%

Biomedical applications of10B and11B NMR

Bendel

2005

NMR Biomed.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Among these methods, TLC-based [51] and capillary isotochophoresis-based [52] methods provided insufficient resolution for all contaminants. NMR-based methods [53,54] cannot provide quantitative data, and HPLCbased methods [55] required a special column, which is not usually commercially available. Recently, Mauri et al [52] developed a new approach for quantitative determination of BSH and its impurities using a CE method.…”

Section: Bshmentioning

confidence: 99%

Recent progress in pharmacokinetic applications of capillary electrophoresis

Lin

Chen

2003

Electrophoresis

View full text Add to dashboard Cite

This review is a continuation of the previous reviews (Electrophoresis 1999, 20, 3259-3268; Electrophoresis 2001, 22, 4244-4248) to update the recent publications from 2001 to 2003 on pharmacokinetic studies using capillary electrophoresis (CE). During this period of time, CE remains as a unique analytical method for some studies, which would otherwise be limited by many factors, such as the sample volume, detection sensitivity, or separation power. It is particularly noticeable that the separation of chiral drugs in biological sample and the use of solid-phase extraction (SPE) as a simple and convenient means of sample preparation appear to become popular for CE-based assays. The use of CE for assessing complete pharmacokinetic information, however, did not show a significant growth during this period of time. In order to provide a broad range of view on how biological samples are analyzed by CE, this review will cover publications during the past two years on the use of CE for the analysis of drugs in biological fluids for general pharmacokinetic applications including drug monitoring and bioavailability studies.

show abstract

“…Diese Verbindungen konnten Bor zu Tumoren transportieren, indem sie in die Proteinsynthese oder den Proteinmetabolismus der schnell wachsenden Tumorzellen ein- hohere Tumor-Hirn-Selektivitat (8.5 : 1) als alle anderen Boronsauren, die damals eingesetzt wurden. 33 …”

Section: Einsatz Borhaltiger Aminosauren In Der Proteinsyntheseunclassified

Die Rolle der Chemie in der Entwicklung einer Krebstherapie durch die Bor‐Neutroneneinfangreaktion

Hawthorne

1993

Angewandte Chemie

131

View full text Add to dashboard Cite

Boron‐11 MRI and MRS of intact animals infused with a boron neutron capture agent

Cited by 48 publications

References 16 publications

Biomedical applications of10B and11B NMR

Biomedical applications of10B and11B NMR

Recent progress in pharmacokinetic applications of capillary electrophoresis

Die Rolle der Chemie in der Entwicklung einer Krebstherapie durch die Bor‐Neutroneneinfangreaktion

Contact Info

Product

Resources

About