Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice

Abstract

Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant (P < 0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition (P < 0.05) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.

Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages

“…), providing evidence that this compound presents activity on inflammation. There are some reports describing that monoterpene compounds, such as borneol, promote anti-inflammatory activity by reducing the leukocyte migration induced by carrageenan in peritonitis model [21]. Our data suggest that EST could have a similar effect on anethole, which was able to decrease leukocytes recruitment in carrageenan-induced pleurisy model, probably attributed to the inhibitory effect on production and/or release of nitric oxide and active metabolites of arachidonic acid [7].…”

Chemical composition of essential oil of exudates of Dryobalanops aromatica

“…The compounds detected in this study (dborneol, terpinen-4-ol, α-terpineol, α-pinene and caryophyllene) are terpenoid compounds well known for their anti-microbial, antiviral, antiinflammatory and cytotoxic effects [14][15][16][17][18][19][20].…”

Determination of borneol and other chemical compounds of essential oil of <i>Dryobalanops aromatica</i> exudate from Malaysia

“…The difference observed in the chemical composition of essential oil reported from the present study and Huang and Lu study might be due to geographical variation of plant species, which lead to difference in environmental and culture conditions. In summary, the compounds detected in this study such as d-borneol, terpinen-4-ol, α-terpineol, α-pinene and caryophyllene are terpenoid compounds, which is a large class of phytochemical well known for its anti-microbial, antiviral, anti-inflammatory and cytotoxic effects [14][15][16][17][18][19][20].Therefore, these terpenes compounds with potential biological activities should be subjected for further investigation. …”