Bordetella Pertussis Infection in Hospitalized Infants with Acute Bronchiolitis

Gökçe, Şule; Kurugöl, Zafer; Aydemir, Sabire; Çiçek, Candan; Aslan, Aslı; Koturoğlu, Güldane

doi:10.1007/s12098-017-2480-4

Cited by 10 publications

(11 citation statements)

References 18 publications

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“…Several studies suggested that B. pertussis is a possible pathogen causing bronchiolitis in infants (8)(9)(10). Several investigators demonstrated that B. pertussis is a common pathogen of bronchiolitis (14,15). A study conducted in Turkey identified 44 (25.6%) of the 172 infants with B. pertussis hospitalized for acute bronchiolitis (15).…”

Section: Discussionmentioning

confidence: 99%

“…Several investigators demonstrated that B. pertussis is a common pathogen of bronchiolitis (14,15). A study conducted in Turkey identified 44 (25.6%) of the 172 infants with B. pertussis hospitalized for acute bronchiolitis (15). Another study showed B. pertussis involvement in 12 of 142 (8.5%) infants hospitalized for bronchiolitis in Finland (9).…”

Section: Discussionmentioning

confidence: 99%

“…Studies reported that B. pertussis coinfection with other respiratory viruses was common in children hospitalized for bronchiolitis; the incidence rate was 36-67% (9,14,15,18). However, the present study reported that 45 (57.7%) patients with B. pertussis were coinfected with other respiratory viruses, which was in agreement with previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger: A 3 Years' Study During a Pertussis Epidemic

Chen

Wang²,

Li³

et al. 2021

Front. Pediatr.

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Objective: In recent years, the incidence of Bordetella pertussis infection in infants and young children has been increasing. Multiple studies have suggested that B. pertussis may be one of the pathogens of bronchiolitis in infants and young children. However, the prevalence and clinic characteristic of B. pertussis in bronchiolitis is controversial. This prospective descriptive study evaluated the prevalence and clinical manifestations of infants and young children hospitalized for bronchiolitis with B. pertussis.Methods: Children hospitalized with bronchiolitis were eligible for a prospective study for 36 months from January 1, 2017, to December 31, 2019. Besides B. pertussis, 10 common respiratory viruses and Mycoplasma pneumoniae (MP) were confirmed by laboratory tests. Medical records of patients were reviewed for demographic, clinical characteristics, and laboratory examination.Results: A total of 1,092 patients with bronchiolitis were admitted. B. pertussis was detected in 78/1,092 (7.1%) patients. Of the 78 patients with B. pertussis bronchiolitis, coinfections occurred in 45 (57.7%) patients, most frequently with human rhinovirus (28/78, 35.9%), followed by MP (9/78, 11.4%), and human bocavirus (6/78, 7.7%). The peak incidence of B. pertussis infection was in May. A high leukocyte count could help distinguish B. pertussis–associated acute bronchiolitis from other acute bronchiolitis etiologies. After excluding coinfections, children with B. pertussis–only bronchiolitis exhibited a milder clinical presentation than those with RSV-only infection; also, children with MP-only and other pathogen infections revealed similar severity. The morbidity of B. pertussis was common (31/78, 39.7%) in infants with bronchiolitis under 3 months.Conclusion: In summary, B. pertussis is one of the pathogens in children with bronchiolitis, and coinfection of B. pertussis with other viruses is common in bronchiolitis. B. pertussis should be considered when patients hospitalized with bronchiolitis present a longer course and have an elevated leukocyte count. Patients with B. pertussis–associated bronchiolitis present a milder clinical presentation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger: A 3 Years' Study During a Pertussis Epidemic

Chen

Wang²,

Li³

et al. 2021

Front. Pediatr.

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“…Studies in recent years have confirmed that RSV and B. pertussis coinfection is common in children [ 3 – 7 ]. In previous studies, comparisons were mainly made between viral bronchiolitis and viral-pertussis coinfection, rather than pertussis and viral-pertussis coinfection, and no differences were found in clinical symptoms [ 3 , 5 ]. Comparison has not been made between pertussis and specific RSV-pertussis coinfection, and the clinical impact of RSV infection on pertussis remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis

Zhang

Deng

2021

BMC Infect Dis

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Background Although Respiratory syncytial virus (RSV) is one of the common pathogens in children with pertussis and viral coinfection, the clinical impact of RSV infection on pertussis remains unclear. We compared clinical characteristics and sought differences between infants with single Bordetella pertussis (B. pertussis) infection and those with RSV coinfection. Methods We enrolled 80 patients with pertussis who were hospitalized in Shenzhen Children’s Hospital from January 2017 to December 2019. Respiratory tract samples were tested for B. pertussis with real-time polymerase chain reaction and respiratory viruses with immunofluorescence assay. Clinical data were obtained from hospital records and collected using a structured questionnaire. Results Thirty-seven of 80 patients had B. pertussis infection alone (pertussis group) and 43 had RSV-pertussis coinfection (coinfection group). No significant differences were found with regard to sex, body weight, preterm birth history, pertussis vaccination, symptoms, presence of pneumonia, or lymphocyte count between the 2 groups. Univariate analysis showed patients with RSV coinfection were older (median, 4.57 months vs 4.03 months, p = 0.048); more commonly treated with β-lactam antibiotics (21% vs 5%, p = 0.044); had higher rates of wheezes (40% vs 14%, p = 0.009) and rales (35% vs 14%, p = 0.028) on chest auscultation, a higher rate of readmission (40% vs 11%, p = 0.004), and a longer hospital stay (median, 10 days vs 7 days, p = 0.002). In the further binary logistic regression analysis, patients with RSV coinfection had higher rates of wheezes (OR = 3.802; 95% CI: 1.106 to 13.072; p = 0.034) and readmission (OR = 5.835; 95% CI: 1.280 to 26.610; p = 0.023). Conclusions RSV coinfection increases readmission rate in children hospitalized for pertussis. RSV infection should be suspected when wheezes are present on auscultation of the chest in these patients. Early detection of RSV may avoid unnecessary antibiotic use.

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“…Although the frequency is reported as high in some studies; it is detected too low in others. [4][5][6][7][8][9] This study aimed to identify the incidence of B. pertussis as pathogen in children with acute bronchiolitis, and to research the effect of its presence on clinical and laboratory features.…”

mentioning

confidence: 99%

The incidence and clinical effects of Bordetella pertussis in children hospitalized with acute bronchiolitis

Efendiyeva¹,

Kara²,

Erat³

et al. 2020

Turk J Pediatr

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Background. Pertussis is a disease leading to high morbidity and mortality in neonates and infants. Bronchiolitis is the most common cause of hospitalization especially in children <2 year-old. Although the clinical findings are different in these two diseases, it is sometimes difficult to make this distinction in partially or fully vaccinated children. This study aimed to identify the incidence, clinical and laboratory effects of B. pertussis as a causative agent in hospitalized children with acute bronchiolitis. Methods. The study included patients diagnosed with acute bronchiolitis and admitted to the Division of Pediatric Infectious Diseases from January 2012 to December 2015, aged 24 months or younger, evaluated for viruses and bacteria with polymerase chain reaction in respiratory tract secretions. Results. The study included 380 patients hospitalized with acute bronchiolitis. Of these patients, 85.8% were identified to be positive for at least one respiratory pathogen. The most commonly identified pathogens were respiratory syncytial virus (RSV) A/B, rhinovirus, parainfluenza virus, adenovirus, bocavirus and metapneumovirus A/B. B. pertussis was only detected in 5 patients (1.5%). In the patients with B. pertussis identified, coinfection with another virus was observed including rhinovirus (n= 2), influenza A virus (n= 1), coronavirus OC43 (n= 1) and RSV A/B (n= 1). The presence of B. pertussis did not appear to cause any significant clinical or laboratory differences in patients. Conclusions. B. pertussis is a rare pathogen in patients admitted to hospital for acute bronchiolitis. However, in patients who do not respond to standard bronchiolitis treatment, B. pertussis should be considered as a causative agent. Early identification of this pathogen is important in terms of quarantining the patient, administering appropriate antimicrobial treatment, and prophylactic treatment to household and other close contacts.

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Bordetella Pertussis Infection in Hospitalized Infants with Acute Bronchiolitis

Cited by 10 publications

References 18 publications

Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger: A 3 Years' Study During a Pertussis Epidemic

Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger: A 3 Years' Study During a Pertussis Epidemic

Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis

The incidence and clinical effects of Bordetella pertussis in children hospitalized with acute bronchiolitis

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