Bordetella holmesii: a rare cause of bacterial endocarditis in a post-splenectomy patient

Clare, Sarbjit; Tariq, Ahmed; Singh, Rohit; Gough, Stephen

doi:10.1136/bcr.11.2009.2459

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…A work-up and treatment should therefore be considered when encountered. Finally, macrolides - antimicrobials used to treat B. pertussis infections - seem to have a lower activity against B. holmesii [12] . In vitro studies report that the most effective antibiotics against B. holmesii are fluoroquinolones and carbapenems which are rarely used to treat pertussis [2] , [13] – [14] .…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Whooping Cough in Switzerland: Differentiating Bordetella pertussis from Bordetella holmesii by Polymerase Chain Reaction

et al. 2014

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Bordetella holmesii, an emerging pathogen, can be misidentified as Bordetella pertussis by routine polymerase chain reaction (PCR). In some reports, up to 29% of the patients diagnosed with pertussis have in fact B. holmesii infection and invasive, non-respiratory B. holmesii infections have been reported worldwide. This misdiagnosis undermines the knowledge of pertussis' epidemiology, and may lead to misconceptions on pertussis vaccine's efficacy. Recently, the number of whooping cough cases has increased significantly in several countries. The aim of this retrospective study was to determine whether B. holmesii was contributing to the increase in laboratory-confirmed cases of B. pertussis in Switzerland. A multiplex species-specific quantitative PCR assay was performed on 196 nasopharyngeal samples from Swiss patients with PCR-confirmed Bordetella infection (median age: 6 years-old, minimum 21 days-old, maximum 86 years-old), formerly diagnosed as Bordetella pertussis (IS481+). No B. holmesii (IS481+, IS1001−, hIS1001+) was identified. We discuss whether laboratories should implement specific PCR to recognize different Bordetella species. We conclude that in Switzerland B. holmesii seems to be circulating less than in neighboring countries and that specific diagnostic procedures are not necessary routinely. However, as the epidemiological situation may change rapidly, periodic reevaluation is suggested.

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Section: Introductionmentioning

confidence: 99%

Diagnosis of Whooping Cough in Switzerland: Differentiating Bordetella pertussis from Bordetella holmesii by Polymerase Chain Reaction

et al. 2014

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“…5,6 B holmesii is mainly seen in respiratory and bloodstream infections, with a few case reports of endocarditis, pericarditis, septic arthritis, and meningitis. 3,4 To our knowledge, this is the first case in the English-language literature to describe endogenous endophthalmitis secondary to B holmesii.…”

Section: Resultsmentioning

confidence: 80%

“… 1 , 2 Most studies to date involving this organism are described in respiratory and bloodstream infections, with several reports of endocarditis, pericarditis, septic arthritis, and meningitis. 1 , 3 The purpose of this study is to report the first case of endogenous endophthalmitis secondary to B holmesii in a patient with SCD.…”

Section: Introductionmentioning

confidence: 99%

Bordetella Holmesii: An Unusual Cause of Endogenous Endophthalmitis in a Patient With Sickle Cell Disease

Pegany

George

Zhang

2020

Journal of VitreoRetinal Diseases

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Purpose: This case report describes a rare organism causing endogenous endophthalmitis in a patient with sickle cell disease. Methods: A case report was conducted. Results: A 41-year-old man with sickle cell disease presented with acute onset of blurry vision of the right eye. His visual acuity was counting fingers in the right eye and 20/20 in the left eye. He had ophthalmic findings of hypopyon and vitritis in the right eye, consistent with endophthalmitis. He was treated with intravitreal and systemic antibiotics. Vitreous cultures grew Bordetella holmesii. His visual acuity at follow-up visits improved to 20/40 in the setting of improved vitritis. Conclusions: This is the first case describing B holmesii, a rare causative organism of endogenous endophthalmitis, in a patient with sickle cell disease. More studies are needed to improve the early detection and treatment of this unusual organism.

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“…Pneumonia, bacteremia with septic shock, cellulitis and suppurative arthritis have also been reported. 4 It is evident from the literature that B. holmesii has a predilection for asplenic patients and/or immunocompromised hosts of any age. Shepard et al 5 published Centers for Disease Control data for 26 cases of bacteremia with B. holmesii, of which 22 were asplenic.…”

Section: Discussionmentioning

confidence: 99%

Bordetella Holmesii Endocarditis

Couturier

Dahl²

2014

Pediatric Infectious Disease Journal

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Bordetella holmesii: a rare cause of bacterial endocarditis in a post-splenectomy patient

Cited by 8 publications

References 13 publications

Diagnosis of Whooping Cough in Switzerland: Differentiating Bordetella pertussis from Bordetella holmesii by Polymerase Chain Reaction

Diagnosis of Whooping Cough in Switzerland: Differentiating Bordetella pertussis from Bordetella holmesii by Polymerase Chain Reaction

Bordetella Holmesii: An Unusual Cause of Endogenous Endophthalmitis in a Patient With Sickle Cell Disease

Bordetella Holmesii Endocarditis

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