Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations

Chamorro, Beatriz; Luca, Karelle De; Swaminathan, Gokul; Longet, Stéphanie; Mundt, Egbert; Paul, Stéphane

doi:10.1128/cmr.00164-22

Cited by 8 publications

(2 citation statements)

References 308 publications

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“…This role for bd- type cytochrome oxidases has been shown in M. tuberculosis , where the bd- type cytochrome oxidase is dispensable for the establishment of infection but is necessary after the initiation of adaptive immunity [18]. In this way, Cyd1 may play a larger role during in B. pertussis, which causes an acute infection that is combated by a strong, and ultimately sterilizing, mucosal immune response, compared to B. bronchiseptica, which typically causes chronic and, in the case of our mouse models, asymptomatic infection (reviewed in [52,53]).…”

Section: Discussionmentioning

confidence: 99%

Cytochrome oxidase requirements inBordetellareveal insights into evolution towards life in the mammalian respiratory tract

McKay,

Spandrio,

Johnson

et al. 2024

Preprint

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Little is known about oxygen utilization during infection by bacterial respiratory pathogens. The classicalBordetellaspecies, includingB. pertussis, the causal agent of human whooping cough, andB. bronchiseptica, which infects nearly all mammals, are obligate aerobes that use only oxygen as the terminal electron acceptor for electron transport-coupled oxidative phosphorylation.B. bronchiseptica, which occupies many niches, has eight distinct cytochrome oxidase-encoding loci, whileB. pertussis, which evolved from aB. bronchiseptica-like ancestor but now only survives only in and between human respiratory tracts, has only three functional cytochrome oxidase-encoding loci:cydAB1, ctaCDFGE1, andcyoABCD1.To test the hypothesis that the three cytochrome oxidases encoded within theB. pertussisgenome represent the minimum number and class of cytochrome oxidase required for respiratory infection, we comparedB. bronchisepticastrains lacking one or more of the eight possible cytochrome oxidasesin vitroandin vivo. No individual cytochrome oxidase was required for growth in ambient air, and all three of the cytochrome oxidases conserved inB. pertussiswere sufficient for growth in ambient air and low oxygen. Using a high-dose, large-volume persistence model and a low-dose, small-volume establishment of infection model, we found thatB. bronchisepticaproducing only the threeB. pertussis-conserved cytochrome oxidases was indistinguishable from the wild-type strain for infection. We also showed that CyoABCD1 is sufficient to cause the same level of bacterial burden in mice as the wild-type strain and is thus the primary cytochrome oxidase required for murine infection, and that CydAB1 and CtaCDFGE1 fulfill auxiliary roles or are important for aspects of infection we have not assessed, such as transmission. Our results shed light on respiration requirements for bacteria that colonize the respiratory tract, the environment at the surface of the ciliated epithelium, and the evolution of virulence in bacterial pathogens.AUTHOR SUMMARYCytochrome oxidases, critical components for aerobic respiration, have been shown to be vital for pathogenesis and tissue tropism in several bacterial species. However, the majority of the research has focused on facultative anaerobes and infections of microoxic to anaerobic host environments, like the gut. We sought to understand the role of cytochrome oxidases during respiratory infection byBordetella bronchiseptica, an obligate aerobe, performing the first analysis of cytochrome oxidases in an extracellular respiratory pathogen that we know of. By comparingB. bronchisepticato the closely relatedB. pertussis, a strictly human-specific pathogen and the causative agent of whooping cough, we found three cytochrome oxidases that are important for growth and survival within the mammalian respiratory tract. We also found that abo3-type cytochrome oxidase, predicted to have a low affinity for oxygen and therefore best suited to ambient air levels of oxygen, was sufficient for both the establishment of infection and persistence in the respiratory tract in mice. Our findings reveal the importance of low affinity cytochrome oxidases in respiratory pathogens, and emphasize the need to study the physiology of diverse pathogens.

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Section: Discussionmentioning

confidence: 99%

Cytochrome oxidase requirements inBordetellareveal insights into evolution towards life in the mammalian respiratory tract

McKay,

Spandrio,

Johnson

et al. 2024

Preprint

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“…The main pathogenic gram-positive bacteria responsible for respiratory ailments include Streptococcus pneumoniae 26 , Group A Streptococcus 27 , Streptococcus agalactiae 28 , Staphylococcus aureus 29 , Mycobacterium tuberculosis 30 , and Corynebacterium diphtheriae 31 . The main pathogenic Gram-negative bacteria implicated are Bordetella parapertussis , Bordetella pertussis , Bordetella bronchiseptica 32 , 33 , Haemophilus influenzae type b 34 , 35 , Klebsiella pneumoniae 36 , Acinetobacter baumannii 37 , Pseudomonas aeruginosa 38 , 39 , and Legionella pneumophila 40 , 41 , which are associated with antimicrobial resistance, posing the greatest threat to modern public health 42 .…”

Section: Respiratory Pathogenic Microorganismsmentioning

confidence: 99%

Respiratory pathogenic microbial infections: a narrative review

Long,

Zheng,

et al. 2024

Int. J. Med. Sci.

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Respiratory infectious diseases have long been recognised as a substantial global healthcare burden and are one of the leading causes of death worldwide, particularly in vulnerable individuals. In the post COVID-19 era, there has been a surge in the prevalence of influenza virus A and other multiple known viruses causing cold compared with during the same period in the previous three years, which coincided with countries easing COVID-19 restrictions worldwide. This article aims to review community-acquired respiratory illnesses covering a broad spectrum of viruses, bacteria, and atypical microorganisms and focuses on the cluster prevalence of multiple known respiratory pathogens in China, thereby providing effective prevention and control measures.

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Novel vaccine candidates of Bordetella pertussis identified by reverse vaccinology

Monterrubio-López,

Llamas-Monroy,

Martínez-Gómez

et al. 2024

Biologicals

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Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations

Cited by 8 publications

References 308 publications

Cytochrome oxidase requirements inBordetellareveal insights into evolution towards life in the mammalian respiratory tract

Cytochrome oxidase requirements inBordetellareveal insights into evolution towards life in the mammalian respiratory tract

Respiratory pathogenic microbial infections: a narrative review

Novel vaccine candidates of Bordetella pertussis identified by reverse vaccinology

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