Cytochrome oxidase requirements inBordetellareveal insights into evolution towards life in the mammalian respiratory tract
Liliana S. McKay,
Alexa R. Spandrio,
Richard M. Johnson
et al.
Abstract:Little is known about oxygen utilization during infection by bacterial respiratory pathogens. The classicalBordetellaspecies, includingB. pertussis, the causal agent of human whooping cough, andB. bronchiseptica, which infects nearly all mammals, are obligate aerobes that use only oxygen as the terminal electron acceptor for electron transport-coupled oxidative phosphorylation.B. bronchiseptica, which occupies many niches, has eight distinct cytochrome oxidase-encoding loci, whileB. pertussis, which evolved fr… Show more
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