Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genes

Lawrence, Peter A.; Johnston, Paul R.; Macdonald, Paul M.; Struhl, Gary

doi:10.1038/328440a0

Cited by 225 publications

(125 citation statements)

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“…Most is known about Drosophila eve, the founding member of the gene family. However, its early segmental expression pattern {Macdonald et al 1986;Frasch et al 1987) is very different from that of most other animals, and its early function in segmentation (Lawrence et al 1987) is apparently acquired (Patel et al 19921.…”

Section: Discussionmentioning

confidence: 99%

Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7.

Ahringer¹

1996

Genes Dev.

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Patterning of the posterior end in animals is not well understood. Homologs of Drosophila even-skipped (eve) have a similar posterior expression pattern in many animals, and in vertebrates they are linked physically to the "posterior" ends of homeotic clusters (HOM-C), suggesting a conserved role in posterior development. However, the function of this posterior expression is not known. Here I show that the Caenorhabditis elegans gene vab-7 encodes an eve homolog that is required for posterior development and expressed in a pattern strikingly similar to that of vertebrate eve genes. Using a four-dimensional recording system, I found that posterior body muscles and the posterior epidermis are patterned abnormally in vab-7 mutants, but commitment to muscle and epidermal fates is normal. Furthermore, vab-7 activity is required for the complete expression of the most posterior HOM-C gene egl-5 in muscle cells, supporting the idea that eve homologs may act with the HOM-C to determine posterior cell fates. The conservation of sequence and expression pattern between vab-7 and eve homologs in other animals argues that most eve genes have posterior mesodermal and ectodermal patterning functions.

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Section: Discussionmentioning

confidence: 99%

Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7.

Ahringer¹

1996

Genes Dev.

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“…The pair rule genes delimit the parasegments in Drosophila and define the domains that will express the segment polarity genes (Lawrence et al, 1987;DiNardo and O'Farrell, 1987;Ingham, 1988;DiNardo et al, 1988;Baker, 1988). Pair rule genes form a crucial tier in the Drosophila segmentation gene cascade as this tier marks the transition from a non-periodic pattern to a periodic pattern.…”

Section: The Transition From a Non-periodic To A Periodic Pattern: Ormentioning

confidence: 99%

Evolutionary conservation and divergence of the segmentation process in arthropods

Damen

2007

Developmental Dynamics

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A fundamental characteristic of the arthropod body plan is its organization in metameric units along the anterior-posterior axis. The segmental organization is laid down during early embryogenesis. Our view on arthropod segmentation is still strongly influenced by the huge amount of data available from the fruit fly Drosophila melanogaster (the Drosophila paradigm). However, the simultaneous formation of the segments in Drosophila is a derived mode of segmentation. Successive terminal addition of segments from a posteriorly localized presegmental zone is the ancestral mode of arthropod segmentation. This review focuses on the evolutionary conservation and divergence of the genetic mechanisms of segmentation within arthropods. The more downstream levels of the segmentation gene network (e.g., segment polarity genes) appear to be more conserved than the more upstream levels (gap genes, Notch/Delta signaling). Surprisingly, the basally branched arthropod groups also show similarities to mechanisms used in vertebrate somitogenesis. Furthermore, it has become clear that the activation of pair rule gene orthologs is a key step in the segmentation of all arthropods. Important findings of conserved and diverged aspects of segmentation from the last few years now allow us to draw an evolutionary scenario on how the mechanisms of segmentation could have evolved and led to the present mechanisms seen in various insect groups including dipterans like Drosophila. Developmental Dynamics 236:1379 -1391, 2007.

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“…w A 1.8 kb Fnull-Accl fragment derived from the wg cDNA clone SP6wg (Rijsewijketal., 1987) thatincludes theentirecodingsequenceflanked by 140 bp of 5' noncoding sequence and 80 bp of 3' noncoding sequence, was inserted into the BamHl and Hincii sites of a polylinker derived from the pucl9 and pSP64 plasmids such that Kpnl and Smal sites are positioned immediately upstream of the 5' Fnuii site and Pstl and Hindlll sites are positioned immediately downstream of the 3'Acci site. A DNA fragment containing the 3' UTR and transcriptional terminating sequences from the al tubulin gene (Theurkrauf et al, 1986;Lawrence et al, 1987') was then fused downstream of the Hindlll site at the 3' end of the wg coding sequence. The 3'end of the a7 tubolin DNA contains an artificial Xbal site allowing the wg coding sequence and al tubulin trailer to be excised as a Kpni-Xbal fragment.…”

Section: Experlmental Procedures Piasmid Constructionsmentioning

confidence: 99%

Organizing activity of wingless protein in Drosophila

Struhl

Basler

1993

Cell

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810

566

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The adult appendages of Drosophila are formed from imaginal discs, sheets of epithelial cells that proliferate during larval development and differentiate during metamorphosis. wingless (wg, DWnt-1) protein, a putative signaling molecule, is expressed only in prospective ventral cells in each of the leg discs. To test the role of wg, we have generated randomly positioned clones of cells that express wg protein constitutively. Clones that arise in the prospective ventral portions of the leg discs develop normally. In contrast, dorsally situated clones give rise to ventrolateral patterns and exert a ventralizing influence on neighboring wild-type tissue. We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc. The adult appendages of Drosophila are formed from imaginal discs, sheets of epithelial cells that proliferate during larval development and differentiate during metamorphosis. wingless (wg, DWnt-1) protein, a putative signaling molecule, is expressed only in prospective ventral cells in each of the leg discs. To test the role of wg, we have generated randomly positioned clones of cells that express wg protein constitutively. Clones that arise in the prospective ventral portions of the leg discs develop normally. In contrast, dorsally situated clones give rise to ventrolateral patterns and exert a ventraliring influence on neighboring wild-type tissue. We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc.

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Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genes

Cited by 225 publications

References 0 publications

Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7.

Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7.

Evolutionary conservation and divergence of the segmentation process in arthropods

Organizing activity of wingless protein in Drosophila

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