Borage oil intake by overweight young adults: no effect on metabolic rate; beneficial effects on plasma triglyceride and HDL cholesterol readings

DiSilvestro, Robert A.; Marston, Susan Olivo; Zimmerman, Autumn; Joseph, Elizabeth; McCarty, Carolynn Boeh

doi:10.1039/d1fo01887f

Cited by 1 publication

(2 citation statements)

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“…Some studies have shown that gamma-linolenic acid (GLA) can increase resting metabolic rate (RMR), which may help with weight control. However, no effect on RMR or body mass index was observed in overweight young adults with a family history of obesity [ 29 ]. A study by Khamaisi et al also showed insulin-sensitizing properties of GLA-alpha-lipoic acid conjugate associated with antioxidant activity [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

“…The available literature shows that linoleic acid lowers blood cholesterol by 13.8%, as predicted by the Keys equation [ 28 ], while γ-linolenic acid lowers TG levels and raises HDL levels [ 29 ]. In an animal model, diets containing γ-linolenic acid from evening primrose oil also significantly reduced serum TG and TCH levels compared to other oils (palm and safflower) [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial

et al. 2022

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Background: Acne vulgaris is one of the most common skin diseases. One of the therapeutic options recommended for severe acne or acne that has not responded to previous therapies is isotretinoin. However, its use may lead to adverse changes in the serum lipid profile and increased levels of transaminases. In this study, we evaluated the effect of supplementation with evening primrose oil in acne vulgaris patients treated with isotretinoin on blood lipid parameters and transaminase activity. Methods: Study participants were randomly assigned to two treatments: conventional with isotretinoin (25 patients) and novel with isotretinoin combined with evening primrose oil (4 × 510 mg/day; 25 patients) for 9 months. Results: Compared to isotretinoin treatment, isotretinoin treatment combined with evening primrose oil had a positive effect on TCH concentrations (mean: 198 vs. 161, p < 0.001), LDL (95.9 vs. 60.2, p < 0.001), HDL (51.0 vs. 48.0, p < 0.001), TG (114 vs. 95.0, p < 0.001), ALT (24.0 vs. 22.0, p < 0.001), and AST (28.0 vs. 22.0, p < 0.001), but had no effect on the energy and ingredient content of the diets (p > 0.05) after treatment. Conclusion: Evening primrose oil was found to have beneficial effects on lipid profiles and transaminase activity during isotretinoin treatment. However, longer studies are needed to make more reliable decisions regarding the use of evening primrose oil and its safety in clinical practice. The evening primrose oil treatment group also showed a reduction in dietary energy due to a reduction in dietary protein and carbohydrates.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial

et al. 2022

View full text Add to dashboard Cite

show abstract

Borage oil intake by overweight young adults: no effect on metabolic rate; beneficial effects on plasma triglyceride and HDL cholesterol readings

Abstract: Some research has raised the possibility that gamma linolenic acid (GLA) can increase resting metabolic rate (RMR), which can help with weight control. However, in overweight young adults with a...

Cited by 1 publication

References 16 publications

Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial

Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial

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